Synthesis of Paclitaxel Analogs

Paclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel analogs have been synthesized and their biological activities have been evaluated. In order to reduce the myelosuppression effect of the paclitaxel, several C3â ² and C4 paclitaxel analogs have been synthesized and their biological evaluation have been studied.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Chemistry

Department dc:contributor.department

Chemistry

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

2010

Author dc:creator

• Xu, Zhibing

Chair dc:contributor.committeechair

• Kingston, David G. I.

Committee members dc:contributor.committeemember

• Carlier, Paul R.
• Santos, Webster L.

• Myelosuppression
• beta-Lactam
• Baccatin
• Inflammation
• 2-Methoxyestradiol
• Tubulin
• Anticancer Drugs
• Cancer
• Paclitaxel
• Antagonists

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Dc Identifier Other

etd-10132010-152742

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/35376