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Showing 1 to 20 of 159 for “"Paclitaxel"”.
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Synthesis of Paclitaxel Analogs
Paclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel …
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Kombination von Paclitaxel und Bestrahlung
Paclitaxel wird als antineoplastisches Agenz hauptsächlich gegen Ovarial- und Brusttumore eingesetzt. Seine Wirkung beruht auf einer Störung der mikrotubulären Dynamik und Struktur des Zytoskeletts, die einen Arrest der Zelle in der G2- und Mitosephase des Zellzykluses bewirkt. Da Zellen, die in …
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Studies on the Chemistry of Paclitaxel
Paclitaxel is a natural occurring diterpene alkaloid originally isolated from the bark of Taxus brevifolia. It is now one of the most important chemotherapeutic agents for clinical treatment of ovarian and breast cancers. Recent clinical trials have also shown paclitaxel's potential for the …
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Synthesis and Biological Evaluation of Paclitaxel Analogs
The complex natural product paclitaxel (Taxol®), first isolated from Taxus brevifolia, is a member of a large family of taxane diterpenoids. Paclitaxel is extensively used for the treatment of solid tumors, particularly those of the breasts and ovaries. In order to obtain additional information …
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Paclitaxel nanoparticles for breast cancer therapy in pregnancy
… to implications on fetal health. A number of new paclitaxel nanoformulations for the treatment of breast cancer are entering clinical studies or are commercially available, but whether or not these formulations cause differences in transplacental transfer and, ultimately, fetal exposure remains to …
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Drug delivery of paclitaxel for an intraperitoneal chemotherapy
… treatment. An interesting drug for HIPEC is paclitaxel. However, the use of paclitaxel is hampered by its poor solubility and the currently used formulation vehicle (Cremophor EL(R)/ethanol). Therefore, the objective of this research project was to develop a tensioactive- and solvent-free …
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Design, Syntheses and Biological Activities of Paclitaxel Analogs
The conformation of paclitaxel in the bound state on the protein has been proposed to be the T-taxol conformation, and paclitaxel analogs constrained to the T-taxol conformation proved to be significantly more active than paclitaxel in both cytotoxicity and tubulin polymerization assays, thus …
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Studies of paclitaxel analogs modified in ring C
The structurally novel diterpenoid paclitaxel (Taxol®), originally isolated from <i>Taxus brevifolia</i>, is one of the most promising new anticancer drugs. Its structural complexity and unique biological activity have provided the impetus for a number of structure-activity relationship (SAR) …
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Novel Paclitaxel Nanoparticles for Enhanced Therapeutic Effects in Breast Cancer
… they pose adverse effects on healthy tissues. Paclitaxel (PTX) has been used as a gold standard chemotherapeutic agent for breast, ovarian, pancreatic and non-small cell lung carcinoma. Till date, PTX has been used as the first line of treatment for metastatic breast cancer. However, being …
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Investigating the Anti-Melanoma Activity of Combinatorial Paclitaxel and MEK Inhibitor
Melanoma has increased considerably over the past forty years. Traditional and newly-developed anti-melanoma drugs do not produce a satisfactory therapeutic response for the treatment of late stage melanoma. Nanomedicine is a potent tool for clinicians to circumvent many of the existing …
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Development and Evaluation of Brain Tumor Targeted Liposome Delivery System for Paclitaxel
… and characterized liposome carriers containing paclitaxel, for targeted delivery to the glioma brain tumors. <br /><br />A liposome drug delivery system specifically aimed at glioma tumors was designed in this study. Liposomes composed of egg phosphotidylchole (EPC), hydrogenated soybean …
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Clinical pharmacokinetics of low dose paclitaxel in Asian patients with nasopharyngeal carcinoma
The pharmacokinetics (PK) of low-dose paclitaxel in Asian patients with WHO Stage III nasopharyngeal carcinoma treated with a chemo-radiation regimen were determined and correlated with subjecta??s demographics, clinical parameters, outcome with the intent of optimizing therapeutic benefit to risk …
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Synthesis and Antiproliferative Activity of C3' and B-ring Modified Paclitaxel Analogs
The natural product, paclitaxel, has made tremendous contributions in supplying the arsenal of anticancer therapeutics, and was FDA approved for clinical use in 1992. In order to design simplified analogs, the conformation that paclitaxel adopts when binding to tubulin has been the subject of …
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Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs
Paclitaxel was isolated from the bark of <i>Taxus brevifolia</i> in the late 1960s. It exerts its biological effect by promoting tubulin polymerization and stabilizing the resulting microtubules. Paclitaxel has become one of the most important current drugs for the treatment of breast and ovarian …
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TLR4 is a novel determinant of the response to paclitaxel in breast cancer
… leading to decreased patient survival. Paclitaxel (PXL) is a potent cytotoxic drug widely used as a first and second line drug-of-choice for the treatment of metastatic breast cancer. However, resistance develops frequently with evasion mechanisms remaining largely unclear. PXL elicits …
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SIK2 Inhibitor GRN-300 Enhances Sensitivity to Paclitaxel Treatment in Triple-Negative Breast Cancer
… primarily relies on chemotherapy, most commonly paclitaxel, a taxane that stabilize microtubules, disrupts chromosome separation and induces apoptosis. However, TNBCs are an aggressive cancer subtype, and patients often will develop resistance after a few rounds of chemotherapy. This study …
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Paclitaxel-induced macrophage activities in the tumor-bearing host: immunologic implications and therapeutic applications
… activities. Because the antineoplastic agent paclitaxel (TAXOL) activates Mf function, we studied mechanisms of paclitaxel-mediated cytotoxic and immunostimulatory responses by tumor-induced Mfs. Although tumor-derived factors, including interleukin-10 and transforming growth factor-b1, …
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Investigating the Role of Insulin-Like Signaling in Paclitaxel-Induced Nociceptive Hypersensitivity using Drosophila melanogaster
<p>Paclitaxel (PTX), a chemotherapeutic that alters microtubule dynamics, is known to induce nociceptive hypersensitivity and sensory neuron damage in human patients and in Drosophila larvae. We used a modified feeding protocol to establish a genetically tractable Drosophila model of PTX-induced …
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