Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3156 for “"Inflammation"”.
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Hypoxic Influences On Myeloid Cells During Inflammation And Inflammation-Associated Cancer
… not only to O2 deprivation at the site of inflammation, but also alter many of their functions in response to hypoxia to either facilitate or suppress inflammation. Hypoxia stabilizes HIF-αs in macrophages and neutrophils, and these O2-sensitive transcription factors are key regulators of …
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Inflammation and arterial stiffness
… have been proposed about the active role of inflammation and endothelial dysfunction in arterial stiffening and early atherosclerosis. The aims of this thesis were to review the literature and to study, for the first time, the arterial stiffness in inflammatory bowel disease.
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Nanoparticles Targeting at Inflammation Site
This thesis presents the development and translational evaluation of advanced nanoparticle-based drug delivery systems designed for the sustained and localized delivery of hydrophobic therapeutics, with a focus on pazopanib. Addressing key challenges in drug solubility, stability, and scalable …
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Nitric oxide in airway inflammation
… is a non-invasive method of investigating airway inflammation associated with nitric oxide (NO) and the metabolites nitrite/nitrates (NOx) in diseases such as chronic obstructive pulmonary disease (COPD), but some of the variables affecting the results are unknown. It was hypothesised that 1) EBC …
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Inflammation, kinins, and kinin receptors
… and their receptors in different settings of inflammation. It is known that BK is generated in the airways of asthmatic subjects and that disease symptoms are exacerbated during respiratory viral infections. In paper I, we report that BK induces an up-regulation of B2 receptors in human airway …
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Studies on allergy and inflammation
The enclosed papers have been classified into five major sections whose content is as follows:
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Biliverdin reductase in cardiovascular inflammation
Biliverdin Reductase (BVR) functions downstream of Heme Oxygenase 1 (HO-1) in the process of heme degradation and catalyses the reduction of biliverdin to bilirubin. For over thirty years, BVR was regarded as rather a trivial enzyme whose only known function was to aid heme disposal. Over the last …
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Brain Inflammation Regulated by PINK1
… study, I analyzed the roles of PINK1 in brain inflammation using slice cultures prepared from PINK1 knockout (KO) and wild type (WT) mice since slicing mimics injury. For up to 24 h after slicing, mRNA expression levels of pro-inflammatory cytokines (TNF-a, IL-1b, and IL-6) measured at 6 to 24h …
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Autophagy and Inflammation During Rickettsial Infection
Rickettsiae are obligately intracellular bacteria that replicate in the cytoplasm of host cells. In my dissertation, I have studied the induction of autophagy by rickettsiae as well as the role of autophagy in the pathogenesis of rickettsioses in vitro and in vivo. I found that autophagy is induced …
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Invertebrate glycoprotein-induced inflammation in rats
The present program of research, therefore, was designed to attempt to gain new insights into the possible etiology of inflammatory states - for when new information concerning the etiology of these diseases states becomes available, more meaningful screening procedures for anti-inflammatory drugs …
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Neutrophil diversity in immunity and inflammation
Contains fulltext : 239947.pdf (Publisher’s version ) (Open Access)
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Intestinal macrophages in health and inflammation
… commensal bacteria would lead to continuous inflammation and ultimately tissue pathology. Indeed, there is mounting evidence that mφ play an essential role in maintaining homeostasis and epithelial renewal in the normal intestine. In contrast, mφ from the intestine of patients with …
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Targeting Nrf2 in Inflammation and Cancer
… proteins. Activation of Nrf2 protects against inflammation and oxidative damage in disease models in vitro and in vivo. Nrf2 activation may be a good therapeutic strategy in these diseases. Some dietary components activate Nrf2, which may be partially responsible for their beneficial effects in …
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NLRP3 in Renal Injury and Inflammation
Renal cell injury, death and inflammation are hallmarks of chronic kidney disease (CKD). Unresolved inflammation can chronically damage renal tissue resulting in fibrosis and kidney failure. The Nlrp3 inflammasome has been implicated in the innate immune response to cellular injury and represents a …
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Mediators of monocyte activity in inflammation
… activity. One of the keys cells involved in inflammation within chronic inflammatory diseases is the monocyte. Monocytes are able to modulate inflammation through cytokine expression, cytosolic peroxide formation, adhesion molecule expression and subsequent adhesion/migration to sites of …
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Polyphosphate modulates hemostasis, thrombosis, and inflammation
… and human platelets play important roles in inflammation and coagulation in vitro and in vivo, supporting the paradigm of polyP as the long-sought (patho)physiologic activator of the contact pathway of blood clotting. These studies also implicate polyP in contributing to thrombosis and …
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The biogenesis of erythropoietin during inflammation
… in experimental models of acute and chronic inflammation was appropriate for the associated anaemia. Macrophage-conditioned medium, interleukin-1β, interleukin-6, tumour necrosis factor-α, and neopterin were assayed for inhibition of erythropoietin synthesis by HepG2 cells in culture. All, …
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