Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"2-Methoxyestradiol"”.
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Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
The goal of this study was to determine safety, tolerability and pharmacokinetics of 2ME2 in patients with solid tumors and determine maximum tolerated dose (MTD). The following hypotheses were tested: 1) 2ME2 will be well tolerated in clinic when given orally and will have quantifiable effects on …
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Supramolecular derivatives of selected bioactive compounds : a physicochemical study
… compounds: the steroidal anticancer agent 2-methoxyestradiol [polymorphs and cyclodextrin (CD) inclusion complexes], its derivative 2-methoxyestradiol-bis-sulfamate (polymorphs), and the antiretroviral agent, nevirapine (co-crystals). The solubility and dissolution profiles of the three …
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THE EFFECT OF FLAXSEED AND ITS LIGNAN COMPONENT ON ESTROGEN SIGNALING AND METABOLISM IN NORMAL AND CANCEROUS HEN OVARIES
… and anti-proliferative metabolite, 2-methoxyestradiol were significantly increased with whole flaxseed diet in the serum from 3 year old (pre-neoplastic hens) as well as 4 year old hens (cancerous and normal hens). These results demonstrated that whole flaxseed had a more significant …
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Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth
… found in broccoli enhanced formation of 2-methoxyestradiol from the parent compound 17β-estradiol in vitro and ex vivo, mainly via upregulation of the phase I detoxification enzyme cytochrome P450 (CYP) 1A. Broccoli inhibited growth of human prostate and ovarian cancer cells via induction …
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ROLE OF OXIDATIVE REACTIVE SPECIES AND ANTIOXIDANTS IN METABOLISM AND TRANSPORT OF THERAPEUTIC DRUGS
… quercetin (Qc), on the metabolism of 2-methoxyestradiol (2Me-E2), a promising potential anticancer agent was investigated. Qc possesses five hydroxyl groups, several of which are targets for UDP-glucuronosyltransferases (UGTs). Thus, the simultaneous presence of Qc and 2Me-E2 could …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
… that curcumin, a turmeric root derivative, and 2-methoxyestradiol (2ME2), a natural metabolite of estradiol, effectively inhibit progestin-induced VEGF secretion from breast cancer cells in vitro. Furthermore, curcumin delays progestin-accelerated DMBA-induced tumorigenesis in Sprague-Dawley rats. …
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Einfluß von Steroidhormonen auf die Endothelzellproliferation und die Expression von Wachstumsfaktoren und ihren Rezeptoren
Diese Studie wurde mit dem Ziel durchgeführt, die Wirkungen von 17ß-Östradiol, 2-Methoxyöstradiol und Progesteron auf die Endothelzellproliferation und auf die<br>Expression von Wachstumsfaktoren und ihren Rezeptoren zu untersuchen. <br>HUVEC, HUAEC sowie HDMVEC und Fibroblasten wurden bis zur …
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Cytochrome P450 1B1 and 12/15 Lipoxygenase Interaction in Paraventricular Nucleus in Angiotensin II-induced Hypertension in Females
… metabolite of 17β-estradiol (E2) (2-methoxyestradiol, 2-ME) and ALOX15 in the paraventricular nucleus (PVN) as a mechanism that protects against Ang II-induced hypertension and its associated pathogenesis in female mice. <strong>Methods:</strong> Experiments were conducted in intact …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
… deficits. HIF-1 a activity was inhibited by 2-methoxyestradiol (2ME2,1.5, 15 or 150 mg/kg) or enhanced by dimethyloxalylglycine (DMOG, 250 mg/kg). 2ME2 treatment exhibited dose-dependent neuroprotection by decreasing infarct volume and reducing brain edema at 48 h post HI. The neuroprotection …
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Synthesis of Paclitaxel Analogs
Paclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel …