Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 252 for “"Tubulin"”.
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DEVELOPMENT OF MOLECULAR PROBES ACTING ON aSYN/TUBULIN AND TAU/TUBULIN INTERACTION
… to mammals mainly consisting of conserved α/β tubulin heterodimers. Neurons are an impressive example of cells in which the contribution of MTs is fundamental to achieve their sophisticated cell architecture and to sustain their functional complexity. A growing body of evidence indicates that …
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Analysis of [alpha]-tubulin in yeast
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1988.
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Catalysis of tubulin heterodimerization in vivo
The heterodimerization of α- and β-tubulin represents a critical early step in microtubule morphogenesis. In vitro studies have defined a pathway that mediates the incorporation of monomeric tubulin polypeptides into heterodimer. The components of this pathway, tubulin cofactors, are dispensable …
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Regulation of tubulin functions in Saccharomyces cerevisiae
… affecting the polymerization of [alpha]/[beta]-tubulin heterodimer subunits to form microtubules. However, there is another class of factors that affect microtubule formation by regulating the steps that precede the polymerization of [alpha]/[beta]-tubulin heterodimer. One of these factors is …
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VERU-111 as an Oral Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer and Evaluation of Novel Tubulin Inhibitors for Cancer Therapy
<p>Triple negative breast cancer (TNBC) has aggressive clinical features strongly associated with poorer overall prognosis and higher mortality rates relative to other molecular subtypes. FDA-approved drugs, such as paclitaxel, are effective in treating TNBC. Yet, treatment failure is commonly …
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FtsZ Protofilament Curvature is the Opposite of Tubulin Rings
<p>Bacterial tubulin homolog FtsZ assembles straight protofilaments (pfs) that form the scaffold of the cytokinetic Z ring. These pfs can adopt a curved conformation forming a miniring or spiral tube 24 nm in diameter. Tubulin pfs also have a curved conformation, forming 42 nm tubulin rings. We …
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Regulation of γ-Tubulin Ring Complex Recruitment in Drosophila
Microtubule nucleation is catalysed by γ-tubulin ring complexes (γ-TuRCs) which are recruited to specific microtubule organising centres (MTOCs) within cells. The recruitment and activation of γ-TuRCs allows regulation of microtubule nucleation in both time and space. Mozart1 (Mzt1) is a …
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Regulation of γ-Tubulin Ring Complex Recruitment in Drosophila
Microtubule nucleation is catalysed by γ-tubulin ring complexes (γ-TuRCs) which are recruited to specific microtubule organising centres (MTOCs) within cells. The recruitment and activation of γ-TuRCs allows regulation of microtubule nucleation in both time and space. Mozart1 (Mzt1) is a …
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COMPUTER-AIDED MOLECULAR DESIGN AND MODELING OF TUBULIN TARGETING AGENTS
… neurodegenerative diseases and neurotoxicity. Tubulin protein is the building block of MTs and is the target protein on which the work described in this Ph.D. thesis is focused. Within the TubInTrain program, the objective of my project is to apply a series of computer-aided molecular design …
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Investigating a novel Asgard archaeon and its tubulin-like proteins
… work, the other major cytoskeletal protein, tubulin, remained largely unexplored in the Asgard Archaea. Eukaryotic tubulins are members of the Tubulin Superfamily (TSF), alongside their prokaryotic counterparts, such as FtsZ, and are critical components of the cytoskeleton. In vitro …
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Regulation Of The Tubulin Code In Cardiac Hypertrophy And Failure
… is poorly understood. Determining how the “tubulin code” – the permutations of tubulin isoforms and post-translational modifications – is rewritten upon cardiac stress may provide new targets to modulate cardiac remodeling. Further, while tubulin can autoregulate its own expression, it is …
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Sulforaphane Inhibits Mammary Cancer Cell Mitotic Progression and Tubulin Polymerization
… spindles, and higher doses of SUL inhibited tubulin polymerization in vitro. In addition, BALB/c mice injected s.c. with F3II cells and subsequently injected daily i.v. with SUL (15 nmol/day for 13 days) developed significantly smaller tumors (∼60% less in mass) than vehicle-treated …
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Regulation of Tubulin dynamics by the +Tip tracking protein Mal3
… via an interaction between the charged tails of tubulin and Mal3. Mal3 MT binding domain structure was solved by X-ray crystallography so that eventually it may be docked into a higher resolution electron microscopy map to provide a more precise structural insight on how Mal3 stabilizes the MT …
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Studies of proteins implicated in the folding and processing of tubulin
Despite much being known about tubulin, there is a dearth of structural information on proteins that are involved folding, processing and manipulating this important component of the cytoskeleton. Trypanosomatids can be used to investigate these proteins, as they are primitive eukaryotes whose main …
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Regulation of the Tubulin Homolog FtsZ in <i>Escherichia coli</i>
<p><em>Escherichia coli</em> is a well-known pathogen, and importantly, a widely used model organism in all fields of biological sciences for cloning, protein purification, and as a model for Gram-negative bacterial species. And yet, researchers do not fully understand how this bacterium replicates …
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Characterization of the alpha- and beta- tubulin polypeptides in Saccharomyces cerevisiae
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Molecular, cellular and physiological aspects of complexes between Gs alpha and tubulin.
… aspects of complexes between Gs alpha and tubulin.
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Effects of Cysteine Modification on Microtubule-Motor Protein Function and Tubulin Assembly
… to inhibit the activity of MT-motor proteins and tubulin assembly. This project seeks to investigate the mechanisms by which NEM affects motor function and inhibits MT minus end assembly. Recombinant motor domains of Drosophila kinesin (DK350 and DK375), Ncd (MC1), and squid kinesin (p181) were …
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Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics
… for all living systems. The interactionsbetween tubulin dimers is already a broadly studied area, whereas the PDZ domaininteractions is a relatively recent area of study. The literature in these areas is reviewed.This research project designed and synthesised novel molecules which were capable …
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Molecular and functional characterization of tubulin isotypes in budding yeast (Saccharomyces cerevisiae)
… are intrinsically dynamic polymers comprised of tubulin protein, which is a heterodimer of - and -subunits. It is proposed that one adaptation that allows MTs to achieve a wide range of functions is the expression of multiple tubulin isotypes. Indeed, most eukaryotes express multiple variants, …
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