Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 57 for “"beta-Lactam"”.
-
Exploring and enhancing context-dependent beta-lactam antibiotic efficacy
Antibiotics, such as beta-lactams, are essential medical tools for the treatment of bacterial infections. Unfortunately, clinical treatment efficacy is declining over time as bacteria adapt to and evade antibiotic treatment through mechanisms called antibiotic resistance, tolerance, and …
-
Stereospecific total synthesis of beta-lactam antibiotics from peptide precursors.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1978
-
Structural characterization of superbug proteins involved in regulating beta-lactam resistance
The widespread use of β-lactams has undermined their effectiveness as chemotherapeutic agents by fueling the evolution and dissemination of multiple resistance mechanisms, including: (1) production of hydrolytic β-lactamase enzymes that inactivate β-lactams, (2) expression of PBPs with …
-
Isolation and characterization of genes from beta-lactam antibiotic producing organisms
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Multivariate Methods for the Study of Beta-lactam Resistance in Streptococci
… of isolates. By applying these tools to beta-lactam resistance in streptococci, I demonstrate these methods can improve visualisation and modelling of complex phenotypes, assist in identifying the molecular basis of multivariate change, and aid in studying repeatable patterns in the …
-
The determination and characterisation of beta lactam resistance in clinical isolates of Acinetobacter baumannII
Bibliography leaves 122-136.
-
Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach
… and pharmacodynamics of many broad-spectrum, beta-lactam antibiotics such as piperacillin/tazobactam, meropenem, and cefepime. The objective of this study is to evaluate the population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam, meropenem, and cefepime in hospitalized …
-
Mechanisms of Regulation and Resistance for Plasmid-Encoded ampC Beta-Lactamase Genes
BETA-lactam antibiotics are the largest class of antimicrobial drugs and the most frequently prescribed world wide. As the use of these agents increased so did the evolution of bacterial BETA-lactam resistance. BETA-lactamases are collectively the most commonly identified BETA-lactam resistance …
-
Molecular methods for the detection of TEM- and SHV-related beta lactamase genes in members of the Enterobacteriaceae
… is a common and important clinical problem. Beta lactam resistance in Gram negative bacilli is mediated predominantly by beta lactamases, enzymes able to hydrolyse the beta lactam ring. The commonest plasmid mediated beta lactamases in the Enterobacteriaceae are those related to either TEM-1 …
-
Antimicrobial Resistance Mediated By Synthesis of Richmond and Sykes Type I Beta-Lactamase
A number of beta-lactam antibiotics that are relatively resistant to hydrolysis by beta-lactamases have been developed. These new compounds have expanded antibacterial activity but also have posed several challenging clinical problems including therapeutic failures and relapses of infections. …
-
Cycloadditions to 1-azetines and 1-azetin-4-ones
… bi-cyclic systems of related structure to the beta-lactam nucleus of beta-lactam antibitics.Thus, three 1-azetine systems (2-4) were prepared by alkylation of their precursor azetidinones and thioazetidinones.The ability of these systems to enter into cycloaddition reactions with a variety of …
-
Molecular Mechanisms of Antimicrobial Resistance In Multi-Drug Resistant Enterococci
… resistant to valuable antibiotics, like beta-lactams, or evolve resistance to all existing antimicrobials. The LiaFSR system regulates resistance to cell membrane (CM) stressors like daptomycin (DAP), a front-line drug for multi-drug resistant infections. DAP resistance (DAP-R) in <em>E. …
-
Enantioenriched Homoaldol Products, Beta-Substituted Ketones, Isoxazolines, and Beta-Lactams Through Elaboration of Allylamine Asymmetric Homoenolate Equivalents: Synthesis and Elucidation of Reaction Pathways
… was converted into an enantiomerically pure beta-lactam via a beta-amino alcohol and a beta-amino acid in six synthetic steps in 25% overall yield.
-
Approaches to investigating antibiotic efficacy and discovery of treatment strategies against antibiotic tolerance
… into the metabolic processes that drive beta-lactam lethality, where we showed that drug-induced disruption of anabolic- catabolic homeostasis is an important factor for beta-lactam activity. Next, I describe an approach towards the discovery of antibiotic adjuvants for treating …
-
Fate and effect of amoxicillin in space and terrestrial water reclamation systems
… to the antibiotics investigated, including many beta-lactam antibiotics and a beta-lactam, beta-lactamase inhibitor combination (amoxicillin with clavulanic acid). In both systems, resistance was present in the system before initiating the amoxicillin experiment. The antibiotic resistance …
Page 1 of 3