Characterising pathways driving aggressive biology and chemoresistance in triple negative breast cancers biology and chemoresistance in triple negative breast cancers

This body of work served to investigate the mechanisms driving chemoresistance in a series of in vitro TNBC cell line models. Molecular characterisation and comparison of drug resistant models allowed for the identification of promising druggable targets, whose efficacy in restoring chemosensitivity was assessed via a number of methods, including RNAi, CRISPR, and targeted inhibition. In all, the preliminary identification of a means to sensitise an otherwise highly aggressive cancer to chemotherapeutics, represents an essential step in order to improve current standard of care practices of an otherwise intractable disease.<br/><br/><br/>

Name dc:type.qualificationname

Doctor of Philosophy

Level dc:type.qualificationlevel

Doctoral Thesis

Grantor dc:publisher.institution

Queen's University Belfast

Year dc:date.issued

2022

Author dc:creator

• McBrien, Charlotte

Advisors dc:contributor.advisor

• Buckley, Niamh
• Mullan, Paul

• Oncology
• breast cancer
• chemoresistance
• triple negative breast cancer
• CDKN1A
• ABCB1
• TP63
• molecular biology
• cell signalling
• RNAi
• drug resistance
• chemotherapy

Language dc:language

eng

Identifier

oai:pure.qub.ac.uk/portal:studenttheses/0557523d-742e-40d6-8af6-19d545082123

OAI identifier oai:identifier

oai:pure.qub.ac.uk/portal:studenttheses/0557523d-742e-40d6-8af6-19d545082123