Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"TP63"”.
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Investigating the transcription factor landscape of the squamous subtype of pancreatic ductal adenocarcinoma
… was used to identify the interactome of TP63 with an outlook to delineate its role in a subtype specific manner, and also identify potential downstream therapeutic targets. ChIP-seq and other genomics-based methods were used to map TP63 chromatin binding, and understand how the enhancer …
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Regulation of estrogen receptor-alpha mediated gene expression and endocrine resistance through estrogen receptor-alpha phosphorylation and micro-RNA in breast cancer
… mediated miRNA regulation. We then identified TP63, a target of miR-101, miR-190 and miR- 196a2, and showed that TP63 plays an important role in estradiol- or growth factor-mediated cellular response in breast cancer cells (MCF-7 and MDA-MB-231) by increasing tumor cell growth and in vitro …
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Deciphering The Roles of Δnp63 In Regulating Epithelial to Mesenchymal Transition, Cancer Progression and Metastasis
… considered the guardian of the genome. The <em>TP63</em> gene encodes multiple isoforms that can be categorized into two main isoforms, TAp63 and ΔNp63, which are expressed in different cellular compartments and have distinct functions in many biological processes. While the Flores laboratory …
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Novel proapoptotic p63 isoforms are driven by an endogenous retrovirus in the male germ line of humans and great apes, likely increasing genome stability
… eines endogenen retroviralen LTRs upstream des TP63-Locus könnte die Wächterfunktion von p63 in hominiden Spezies sehr deutlich verstärkt haben. Dieser Event könnte durch die damit verbundene gesteigerte Stabilität der Keimbahn zur Evolution von Menschen und Menschenaffen beigetragen und deren …
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Investigating The Roles of Tap63 and Tap73 In Cutaneous Squamous Cell Carcinoma and Lung Adenocarcinoma
<p>TP63 and TP73 (which encode p63 and p73, respectively) are highly conserved transcription factors with important roles in development and tissue homeostasis. Similar to their homolog, p53, both p63 and p73 have been shown to mediate tumor suppression in multiple tissue types. Interestingly, …
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Characterising pathways driving aggressive biology and chemoresistance in triple negative breast cancers biology and chemoresistance in triple negative breast cancers
This body of work served to investigate the mechanisms driving chemoresistance in a series of in vitro TNBC cell line models. Molecular characterisation and comparison of drug resistant models allowed for the identification of promising druggable targets, whose efficacy in restoring …