Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"ABCB1"”.
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Genetic Determinants of ABCB1 Promoter Activity and Their Effects on Environmental Exposure
… transporter is P-gp, which is encoded by the ABCB1 gene. Many medications prescribed to pregnant women, such as antibiotics for acute illness or medications used to treat chronic diseases including asthma and diabetes, are P-gp substrates. Variability in placental P-gp expression and activity …
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Associations of genetic variants in ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1 with statin-associated muscle symptom (SAMS) in South African populations
… susceptibility to pharmacogenetic variability of ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1, particularly in Asian and European populations. However, limited knowledge exists regarding the impact of pharmacogenetics on statin tolerance among South African patients. This study aimed to examine the …
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Pharmacogenetics of resistant hypertension: evaluating the role of genetic variation in ABCB1, ADBR1, CES1, CYP3A4, CYP3A5, NEDD4L, NOS3, NR3C2 and SCNN1B among South African hypertensive patient
… role of genetic variation in nine genes, namely, ABCB1, ADBR1, CES1, CYP3A4, CYP3A5, NEDD4L, NOS3, NR3C2 and SCNN1B, in the development of resistant hypertension in South African patients. Knowledge of pharmacogenetic variants that play a role in resistant hypertension may potentially improve …
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The Role of Astrocyte-Derived Factors in the Regulation of Multidrug Resistance at the Developing Blood-Brain Barrier
P-glycoprotein (P-gp; encoded by Abcb1) at the blood-brain barrier (BBB) plays an important role in regulating the movement of exogenous and endogenous substrates into the developing brain. P-gp levels in brain endothelial cells (BECs), which form the capillaries of the BBB, increase dramatically …
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The Relationship between methylation and genes associated with opioid response in humans.
… alterations. The promoter region methylation of ABCB1/MDR1, CYP2D6 and OPRM1 genes were analysed by pyrosequencing in smoking, opioid exposed and control pilot populations. Genetic variations within ABCB1/MDR1, COMT, CYP2B6, CYP2D6 and OPRM1 genes were also investigated. Tissue opioid …
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The influence of genetic polymorphisms and natural health products on drug metabolism
… the influence of polymorphisms within the ABCB1 gene on P-gp efflux activity and expression. Additionally, the role of natural health products (NHPs) on the activity of both P-gp and members of the CYP3A subfamily was also studied. Findings from this study suggest that the haplotype …
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Advancing Precision Medicine in Psychiatry: Genetic Insights into Antidepressant Treatment Outcomes
… such as CYP2C19 (drug metabolizing enzyme) and ABCB1 (encoding the drug-efflux transporter P-glycoprotein), and broader polygenic liability may partly explain this variability. Recent advances in psychiatric genomics have enabled the use of polygenic risk scores (PRSs) to quantify the cumulative …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
… 3 (MDR1 and 3)/ABC subfamily B members 1 and 4 (ABCB1 and 4), multidrug resistance associated proteins 1 and 2 (MRP1 and 2)/ABCC1 and 2 and breast cancer resistance protein (BCRP)/ABCG2 was initially studied in term human placenta, cultured primary trophoblast and BeWo and Jar trophoblast-like …
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Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients
… CYP2B6, CYP3A4/5 and the drug transporter ABCB1. Genetic variability in the above genes may contribute to differences in EFV plasma concentrations which affect the levels of viral suppression as well as development of side effects in patients. The aim of this project was to evaluate the …
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Valor pronóstico y predictivo de polimorfismos en genes relacionados con el metabolismo y el mecanismo de acción del cabazitaxel en pacientes con cáncer de próstata avanzado
… de acción de cabazitaxel (CYP3A4, CYP3A5, ABCB1, TUBB1, CYP2C8). La presencia/ausencia de alelos mutados de los SNP seleccionados, se correlacionó con las características clínicas de CPRCm, la SLP, la SG y la toxicidad de cabazitaxel mediante la realización de análisis univariante y …
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The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
… accumulation) and EGFR and P-glycoprotein (ABCB1 gene) mRNA expression, using quantitative Real-Time PCR. When used as an individual treatment, EGFRi demonstrated a higher growth inhibition in both MCF-7 and MDA-MB 231 cell lines, compared to DOX and CDDP. Combination treatment of DOX with …
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Pharmacokinetic-Pharmacogenetic-and-Pharmacodynamic Adherence Relationships in Cohort South African HIV Infected Children on Lopinavir-and Nevirapine-Based Regimens
… Cmin and AUC and genetic polymorphisms in the ABCB1, CYP3A4, CYP3A5 and SLCO1B1. CYP2B6 516G→T and CYP2B6 983T→C were associated with NVP CL/F. CYP2B6 983T→C was associated with NVP Cmin and AUC. Additionally, polymorphisms in the ABCB1 and CYP3A5 were independently associated with NVP CL/F, …
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The relationship between genes associated with the pain pathways and the development of chronic shoulder pain and disability in South African breast cancer survivors
… Cassette- Subfamily B, Member 1 Gene (ABCB1); (rs1045642 G>A; rs1128503 G>A), (II) Opioid Receptor, Mu 1 Gene (OPRM1); (rs1799971 A>G; rs540825 T>A) and (III) Catechol-O-Methyl Transferase Gene (COMT); (rs6269 A>G; rs4633 C>T; rs4818 C>G; rs4680 G>A) and the prevalence of chronic pain …
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Investigations into the Lipid Transport Mechanisms and Energetics of Bacterial ATP-Binding Cassette (ABC) Transporters MsbA and LmrA
… the mammalian multidrug resistance transporter ABCB1 (P-glycoprotein) characterised to have multidrug transport activity. A distinctive feature of LmrA as a primary-active transporter is its ability to harness electrochemical ion gradients. When measured in an electrophysiological setting, LmrA …
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Modelling RANBP2-ALK-rearranged Epithelioid Inflammatory Myofibroblastic Sarcoma
… reduced CD30 expression and induction of ABCB1 was associated with tumour regrowth during therapy. Therefore, combination therapies identified by rational selection and high-throughput screening were considered. BV resistance was reversed in vitro by combination with tariquidar, an ABCB1 …
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Brain microvascular endothelial cell dysfunction in schizophrenia: a preliminary report
… (TEER) and efflux transporters activity of ABCB1 and ABCC1. We observed evidence of poor cellular adhesion and disrupted tight junctions in a subset of SZ hiPSC-derived BMECs, where approximately 70% of them demonstrated extensive BBB disruption (reduced TEER). These findings suggest that …
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Roles of Nanog, a transcription factor for self-renewal of embryonic stem cells, in prostate tumor initiation and chemoresistance
… Nanog expression. The increased expression of ABCB1 and ABCG2 at protein levels in Nanog expressing cells was confirmed by Western blot and immunocytochemistry. Inhibition of ABCB1 activities sensitized Nanog expressing cells toward Taxol and vinblastine, and to less extent, doxorubicin. …
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On the mechanisms of substrate translocation by the ABC transporter MsbA
… multidrug resistance P-glycoproteins (P-gp, ABCB1) and might share functional features and substrate transport mechanisms with ABCB1. Furthermore, MsbA’s Lipid-A transport in Gram-negative bacteria is vital for the biogenesis and maintenance of the outer membrane, which, in turn, is essential …
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… for gastrointestinal efflux transporters ABCB1 (P-gp) or ABCG2. No significant correlation was found between CL/F and demographic, body measures and other clinical covariates, and inter-patient variability in CL/F remained similar in magnitude even after correcting dose for body surface …
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Treatment of HIV associated neurocognitive disorders
… from potentially relevant genes (ABCC5, ABCG2, ABCB1, SLCO2B1, SCLO1A2, ABCC4, CYP2B6 and CYP2A6) and 880 met a linkage disequilibrium (LD)-pruning threshold. We investigated genetic polymorphisms associated with CSF exposure of efavirenz and its metabolites, tenofovir and emtricitabine. The …
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