Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"CDKN1A"”.
-
Nuclear receptor co-repressor functions in prostate cancer; in vitro, in vivo and in silico approaches
… via Microfluidic Gene-Card analysis (Q-RTPCRm). CDKN1A was de-repressed by the knock down and its activation via VDR was modeled with a systems biology approach to identify the mechanistic events behind CDKN1A transcriptional regulation via miRNAs. Differential equation models revealed a …
-
Strahleninduzierte Genexpression von Zellzykluskontroll- und DNA-Reparaturgenen als Biomarker für individuelle Strahlenempfindlichkeit
… Lympho¬zyten wurde die Induzier¬barkeit von CDKN1A (p21, Cip1, WAF1), PCNA, TP53, XPC, GADD45A und DDB2 4h nach Bestrah¬lung in vitro bestimmt. Die erhaltenen Induktionswerte wurden mit dem Ausmaß der Neben¬wir¬kun¬gen ver¬glichen, die die Patienten während ihrer Bestrahlung tatsächlich …
-
Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… or apoptosis. One of the p53 target genes is <em>CDKN1A</em> which encodes the cyclin dependent kinase inhibitor p21. p21 halts cell-cycle progression in response to DNA damage and can also induce senescence. However, p21 expression in cancer cells undergoing chemotherapy allows survival by …
-
Die Rolle der Zinkfingerproteine ZFP36L1 und ZFP36L2 und ihrer Targets in der Imatinib-Resistenz in der chronischen myeloischen Leukämie
… kann unter anderem der Zellzyklusinhibitor CDKN1A verantwortlich sein, der in den ZFP36L1-Knockoutzellen vermehrt exprimiert war. Die mRNA-destabilisierenden Proteine ZFP36L1 und ZFP36L2 sind trotz vorbeschriebener differentieller Funktion bisher als Tumorsuppressorgene bekannt, da viele …
-
Effects of BRCA1-Mediated Ubiquitination of HuR on RNA Metabolism in Breast Cancer
… and its binding to target transcript CDKN1A, and preliminary data indicates CDKN1A stability is also affected. Together, these findings elucidate a new pathway through which BRCA1 mutations may lead to transcriptome dysregulation and alter gene expression in breast cancer patients, …
-
The roles of human cytomegalovirus US27 gene product during virus infection
… and down-regulation of cell cycle regulators CDKN1A (cyclin dependent kinase inhibitor 1A) and SESN2 (Sestrin2 or Hi95). These results indicate that increased cell proliferation due to US27 may be linked to suppression of negative growth regulators. In addition, US27 was shown to increase …
-
Functional Identification of MicroRNAs Counteracting Cellular Senescence
… sequencing, to identify putative miRNA targets. CDKN1A and GRIN3B were identified as possible targets, while the mTOR pathway was observed to be necessary for miRNA induced proliferation. Finally, miR-523-3p and let-7i-3p were administered in vivo in aged mice to assess their effect on …
-
Characterization of the TCOF1 Gene Using a Neuroblastoma Cell Line and a Mouse Model
… knockdown cells and p19 (Cdkn2d), p53 and p21 (Cdkn1a) levels are increased in Tcofl overexpressing cells. Our results suggest that an optimal Tcofl level is required for cell proliferation and survival, and that overexpression and knockdown of Tcofl may affect cell proliferation and apoptosis …
-
Overcoming radioresistance by targeting p21 in cancer
… p53. The cyclin-dependent kinase inhibitor p21 (CDKN1A), also known as p21WAF1/Cip1, is the main p53 transcriptional target and it is traditionally recognized as a tumor suppressor since it is involved in genomic stability preservation, cell cycle arrest or senescence induction, and DNA repair. …
-
The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes
… and mRNA expression in T2D islets, including CDKN1A, PDE7B, SEPT9 and EXOC3L2. Our functional experiments provided further evidence that altering the expression of these genes, by modeling the situation in T2D, results in impaired insulin and glucagon secretion in cell line models. …
-
Contribución de prefoldina a la expresión génica en células humanas
… un efecto de PFDN5 sobre la expresión del gen CDKN1A, que codifica para p21, un represor de la progresión del ciclo celular. Además, hemos detectado que PFDN5 se localiza físicamente sobre dicho gen. Este resultado nos permite explicar su influencia sobre la expresión de genes que se expresan …
-
Characterization of Fasting-Induced p21 Expression and Protection of Intestinal Stem Cells
… cell cycle. Additionally, the p21 gene, <italic>Cdkn1a</italic> (hereafter <italic>p21</italic>) is often used as a marker of cellular stress. To investigate <italic>p21</italic> promoter activity under basal conditions and in response to various forms of stress, we generated knock-in imaging …
-
Caractérisation fonctionnelle des ARNS circulaires du gène PAX-5 dans les cancers lymphoïdes
… avons établi une liste de cibles d’ARNm (ex : CDKN1A, BCL2, BCL10 et BCL2L11) potentiellement régulées par les miRs épongés sur le circPax-5_2-5. Nous avons donc validé expérimentalement (via une lignée de cellules B caractérisée par une surexpression recombinante et stable de circPax-5_2-5) …
-
Androgen receptor-mediated growth suppression and apoptosis of human prostate epithelial cells
… CDK6 genes and transcriptional activation of the CDKN1A/p21 gene. Further, AR inhibits cyclin D2 transcription and destabilizes cyclin D1 mRNA in HPr-1AR cells. The decreased expression and activity of cyclin D-CDK4/6 complexes lead to a prolonged G0/G1 interval and, therefore, restrains cell …
-
Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer
… relative gene and protein expressions of TP53, CDKN1A/p21, and BCL-2 relative to GAPDH on human PBL were studied using the Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) and Western Blot techniques, respectively. Our results have shown altered gene and protein expression …
-
Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer
… relative gene and protein expressions of TP53, CDKN1A/p21, and BCL-2 relative to GAPDH on human PBL were studied using the Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) and Western Blot techniques, respectively. Our results have shown altered gene and protein expression …
-
Functional analysis of ANKRD11 and FBXO31: two candidate tumour suppressor genes from the 16q24.3 breast cancer loss of heterozygosity region.
… of the p53[superscript R273H] mutant to the CDKN1A promoter, implicating a role for ANKRD11 in the restoration of mutant p53[superscript R273H] function. These findings demonstrate a role for ANKRD11 as a p53 coactivator and illustrate the potential of ANKRD11 in the restoration of mutant …
-
p53 activity during adenovirus infection
… Jedoch wurden keine p53 Zielgene wie p21/CDKN1A, mdm2, oder PUMA induziert und somit die transkriptionelle p53 Aktivität komplett inhibiert. Wir fanden weiterhin, dass das adenovirale E1A Protein die p53 Aktivität in der Abwesenheit von E1B-55kDa hemmt. Dabei inhibieren zwei Regionen des …
-
The role of conexin 43 in murine sertoli cell development
… p27Kip1, p21Cip1 and SKP2 (also known as CDKN1B, CDKN1A and p45, respectively). Roles of these cell cycle regulators on Sertoli cell development have been studied and Sertoli cell numbers were significantly altered in the absence of one or more of those cell cycle regulators. In addition, some …
-
Transcriptomic and metagenomic impacts of dietary energy of milk replacer in pre-weaned Holstein heifers
… cell proliferation (LD = 2, A = 3; i.e. GADD45A, CDKN1A). There was a difference in both the transcriptome and rumen microbiome of calves fed differing levels of dietary energy. The calves on the R diet had a rumen microbial composition more similar to a younger calf, while the composition of E …
Page 1 of 2