Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 72 for “"Sensitise"”.
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Time controlled photo-oxidation of polyolefins by polymer bound additives
… antioxidant photoactivator (FeDNC ) was found to sensitise the photoactivity of pro-oxidants (Metone A / Metone M) whereas an antioxidant (ZnDNC) was found to stabilise the polymer (PP and PE) containing both of these combinations. It was observed that the lower concentration of FeDNC sensitises …
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Characterising pathways driving aggressive biology and chemoresistance in triple negative breast cancers biology and chemoresistance in triple negative breast cancers
… the preliminary identification of a means to sensitise an otherwise highly aggressive cancer to chemotherapeutics, represents an essential step in order to improve current standard of care practices of an otherwise intractable disease.<br/><br/><br/>
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Investigation into tracking systems used to follow up pregnant girls in selected government secondary schools in Kalulushi district, Copperbelt, Zambia.
… the importance of the study which also aimed to sensitise stakeholders on the issues involved in teenage pregnancy by raising them for discussion. Further, the study used a qualitative method using a descriptive survey design. Interview guides, were used to obtain in-depth information from the …
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Investigation into tracking systems used to follow up pregnant girls in selected government secondary schools in Kalulushi district, Copperbelt, Zambia.
… the importance of the study which also aimed to sensitise stakeholders on the issues involved in teenage pregnancy by raising them for discussion. Further, the study used a qualitative method using a descriptive survey design. Interview guides, were used to obtain in-depth information from the …
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Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment
… Oncostatin M receptor (OSMR) overexpression and sensitised these cells to Oncostatin M (OSM) leading to increased Signal transducer and activator of transcription 3 (STAT3) phosphorylation, cell migration, invasion and proangiogenic signalling. The aim of this PhD project was to study the role of …
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Targeting pro-inflammatory mediators to treat visceral pain
… with pain in IBD and IBS, and TNFα is known to sensitise colonic sensory neurons. Somatic, TNFα-triggered thermal and mechanical hypersensitivity is mediated by TRPV1 signalling and p38 MAPK activity respectively, downstream of TNFR1 receptor activation. I therefore sought to investigate whether …
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Targeting the DNA damage response protein ATR kinase in pancreatic cancer
… Ataxia Telangiectasia Mutated (ATM), to sensitise PDAC models to ATRi/gem. I found that complete loss of ATM function - through kinase inhibition or through CRISPR knockout, but not ATM depletion by RNA interference - sensitised to ATRi and ATRi/gem in PDAC models. Using flow cytometry …
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Exploring the effect of genetic calpain disruption on cell migration, invasion, drug sensitivity, and metastasis in triple negative breast cancer
… 2, would synergise with calpain knockout to sensitise triple-negative breast cancer cells to paclitaxel and impede migration and invasion in vitro. By understanding calpain’s role in metastasis, we aim to improve the efficacy of existing chemotherapeutics by combining them with …
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Prevalence, clinical presentation and risk factors pf ocluar trauma at the University Teaching Hospital Eye Hospital, Lusaka, Zambia
… largely normal i.e ranging from 6/6 to 6/18. To sensitise parents in homes and workers in work places on ocular trauma. To To sensitise parents in homes and workers in work places on ocular trauma. To institute work place policies that makes it mandatory for workers to wear protective institute …
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Engineering therapeutic messenger RNA for triple-negative breast cancer
… that artificial overexpression of HER2 could sensitise TNBC xenograft models to trastuzumab, however the clinical relevance of this strategy was limited by the use of viral vectors. Messenger RNA (mRNA) technology has been cemented as a safe and effective therapeutic modality, as evidenced by …
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Investigating the role of HOTTIP, HOXA13 and PSIP1 in cancer.
… methods to enhance therapy response or re-sensitise tumours to chemotherapy.
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Some aspects of free radical polymerisation in UV-curing
… investigated and it wasconfirmed that lix can sensitise the -cleavage of 1RG907. Photoinduced fragmentation of aminoalcohols by quinoxalines are discussed and the reactivity of the aminoalcohols reflect their ability to undergo electron transfer and to fragment.A wide range of aminoalcohols …
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The development of a novel therapeutic strategy for the treatment of prostate cancer by targeting metabolic signalling
… induce caspase-independent cell death and to sensitise cells to ROS. Importantly, the inhibitory activity of succinylacetone in combination with ROS showed specificity for cancer cell lines. Targeting heme synthesis therefore represents a novel targeted treatment option for prostate cancer and …
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Factors affecting the retention levels of pupils in public primary schools in selected schools in Kitwe district.
… conduct aggressive campaigns through churches to sensitise the community on the importance of education.
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Factors affecting the retention levels of pupils in public primary schools in selected schools in Kitwe district.
… conduct aggressive campaigns through churches to sensitise the community on the importance of education.
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Targeting integrin alpha 5 and focal adhesion kinase to overcome azacitidine resistance in higher risk myelodysplastic syndromes
… integrin alpha 5 and focal adhesion kinase to re-sensitise azacitidine resistant HSPCs to azacitidine that could be used as a novel therapeutic approach in higher risk myelodysplastic syndrome.
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Toll-like receptor expression and signalling in rat trigeminal neurons: Consequences for oral infection and mechanisms of orofacial pain.
… cytokines which are known to activate and sensitise neurons. The activation of neuronal TLRs may therefore contribute to the increased neuronal excitability and pain that accompanies common orofacial disorders.
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The artist interrogates violence: A Practice-as-research project considering the efficacy of different forms and styles of theatre through a portfolio approach which articulates and animates narratives of violence in private and public domains.
… as a dialogical tool, playing with imagery to sensitise audiences to explicit and sensitive subjects. Each creative work is animated by one of my research questions, and experiments with form and modes of receivership to create a suite of interlocking works aiming to add to the wider debate and …
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Characterising Triflupromazine as a potential agent to treat glioblastoma multiforme
… aimed to identify small molecule inhibitors that sensitise glioma neural stem cells to cell death. My findings identified Triflupromazine, a brain-penetrant phenothiazine as a potent inducer of significant cell death in multiple glioma stem cells lines. Further experiments on its underlying …
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Use of a direct, positive selection strategy to generate improved prodrug-activating enzymes for cancer gene therapy
… vectors were generated and their ability to sensitise SKOV3 cancer cells tested. T41G N71S was ~2-fold improved relative to WT NTR. Purified enzymes were also tested with SKOV3 cells, with T41G N71S being ~2.6-fold improved relative to WT NTR. My best enzyme should be considered when planning …
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