Lethbridge, Alta. : University of Lethbridge, Dept. of Physics and Astronomy
A multi-compartment pharmacokinetic model of docetaxel
Abstract
dc:description.abstractDocetaxel is a clinically active chemotherapeutic agent commonly used in the treatment of solid tumors. It is administered within a micelle encapsulation, polysorbate 80, via intravenous infusion. Docetaxel is known to have a high degree of interpatient variability in its pharmacokinetic behaviour. In this work, intensive, quantitative, compartmental pharmacokinetic models of docetaxel and its vehicle polysorbate 80 are developed. These models introduce both saturable kinetics and power-law relationships to the kinetic behaviour of these molecules. When fit to clinical data available in the literature by minimizing the weighted percentage variance these models out perform traditional linear models. A threecompartment model of docetaxel with both saturable and fractal effects is shown to accurately describe docetaxel pharmacokinetics. From this model pharmacokinetic metrics such as the maximum concentration, the area under the curve, and the half-life are derived. The sensitivity of this model’s parameters to interpatient variability is also investigated.
Degree
thesis:*- Grantor dc:publisher
- Lethbridge, Alta. : University of Lethbridge, Dept. of Physics and Astronomy
- Year dc:date.issued
- 2023
Author and committee
dc:creator, dc:contributor.*- Authors dc:creator
-
- Kuhn, Alissa J.
- University of Lethbridge. Faculty of Arts and Scince
- Advisor dc:contributor.supervisor
-
- Vos, Kenneth
Subjects
dc:subject × 4Rights
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- Identifier
- hdl:10133/6673