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These models introduce both saturable kinetics and power-law relationships to the kinetic behaviour of these molecules. When fit to clinical data available in the literature by minimizing the weighted percentage variance these models out perform traditional linear models. A threecompartment model of docetaxel with both saturable and fractal effects is shown to accurately describe docetaxel pharmacokinetics. From this model pharmacokinetic metrics such as the maximum concentration, the area under the curve, and the half-life are derived. The sensitivity of this model’s parameters to interpatient variability is also investigated.","abstract_has_math":false,"creators":["Kuhn, Alissa J.","University of Lethbridge. 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