Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Docetaxel"”.
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Docetaxel uptake and modulation of P-gpmediated docetaxel efflux by tyrosine kinase inhibitors in human lung carcinoma cell lines
Treatment with the taxanes, docetaxel and paclitaxel, can result in the emergence of multi-drug resistance (MDR) mediated by P-gp (MDR-1, ABCB1), which is an effective cellular efflux pump for both agents. This thesis was undertaken to examine the contribution of drug transport mechanisms to …
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Advancing prostate cancer therapy: synthesis and characterization of docetaxel-loaded magnetic iron oxide nanoparticles for controlled drug release.
… administration methods of front-line drugs like Docetaxel (DXL) face challenges, including non-specific treatment causing several side effects and the development of drug resistance, which affects patients' response and quality of life during treatment. Hence, there is a need for drug carriers …
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Comparison of two neoadjuvant chemotherapy in locally advanced breast cancer patients; Adriamycin and Docetaxel (AD) versus Adriamycin, Cyclophosphamide followed by Paclitaxel (AC-T)
… We compared the women received adriamycin and docetaxel (AD) with adriamycin, cyclophosphamide followed by paclitaxel (AC-T) as neoadjuvant chemotherapy from 1 November 2005 to 31 September2011. The AD group was scheduled for 6 cycles of AD (50mg/m2 and 75mg/m2, respectively) in the interval of …
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An innate immune response to DNA damage in prostate cancer
… Resistant Prostate Cancer (CRPC) treated with docetaxel in the NI Cancer Centre. Samples were microarray profiled, signature scored and defined as DDRD positive or negative.<br/><br/>Results<br/>siRNA mediated knockdown of BRCA1, BRCA2 and ATM resulted in up regulations of DDRD associated …
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Application of pharmaceutical technologies to improve the activity of cancer chemotherapeutic agents
… improve the activity of chemotherapeutic agents. Docetaxel is a second generation taxane used as a single agent in breast cancer, non-small cell lung cancer, and other cancers. Side effects related to the drug itself and one of the excipients (i.e. Tween 80) are extensive. I designed a solid lipid …
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Course of clinical response during primary systemic therapy with a dose-dense 4 cycles regime of adriamycin and docetaxel in patients with operable cancer of the breast
… N0-2, M0) in the dose-dense doxorubicin plus docetaxel (ADoc) therapy arm of the Geparduo trial (2005), a prospective randomized controlled phase III trial, has been investigated. <br>Primary aim was to assess the predictive value of clinical response for the primary endpoint, pathologic …
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Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs
… are curative. Among them, paclitaxel and docetaxel are two of the most effective drugs for HRPC. More importantly, docetaxel is the only form of chemotherapy known to prolong survival in the HRPC patients. We hypothesized that the conjugation of paclitaxel or docetaxel with an androgen …
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Establishment and characterisation of chemoresistant osteosarcoma cell lines by single and multi-agent induced strategies
… for relapsed patients is gemcitabine and docetaxel combination chemotherapy (GEMDOX). A systematic review was performed in this study to investigate the efficacy of combination therapy of gemcitabine and docetaxel on relapsed osteosarcoma patients. The results showed the age and gender of …
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Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… agent and also when used in combination with docetaxel. The results indicate the potential of using ALDH-affinic compounds as single agents for therapeutic intervention or in combination with docetaxel to sensitise resistant cells to this anticancer drug. The data in this thesis provides novel …
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Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… agent and also when used in combination with docetaxel. The results indicate the potential of using ALDH-affinic compounds as single agents for therapeutic intervention or in combination with docetaxel to sensitise resistant cells to this anticancer drug. The data in this thesis provides novel …
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Co-encapsulation of anti-breast cancer drugs in nanoparticles reduce antagonism
… of cancer remission. Differential metabolism of docetaxel (DCL) and tamoxifen (TAM), which resulted in drug antagonistic effects were shown to suppress treatment efficacy in subpopulation of cancer cells. However the potential of nanoparticles, which spatially protected both drugs from …
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Molekulární mechanismy indukce apoptosy u nádorových buněk
… železa, klinicky používanými taxany (paclitaxel, docetaxel) a nově syntetisovanými fotosensitivními látkami. Z presentovaných publikací jsme získali tyto závěry. (1) Studie týkající se indukce apoptosy deprivací železa prokázaly účast odlišných signálních drah vedoucí k indukci apoptosy u myších a …
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Valor pronóstico y predictivo de polimorfismos en genes relacionados con el metabolismo y el mecanismo de acción del cabazitaxel en pacientes con cáncer de próstata avanzado
… a la castración (CPRCm) después de progresión a docetaxel. A pesar de su eficacia comprobada, existe variabilidad en la respuesta, la supervivencia libre de progresión (SLP) y la supervivencia general (SG) de los pts. Los cambios en la constitución genética del individuo, como los polimorfismos …
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The role of microvesicles in EMT and tumour microenvironment
… exposed to serum starvation and anti-cancer drug docetaxel, produce excessive level of MMP-9 and 2/3 of total TPNT2 cell population were arrested in the G2/M phase of the cell cycle, and halts cell proliferation. The influence of carcinoma cell derived-MVs on tumour microenvironment was examined …
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The Role of Platelets In Ovarian Carcinoma
… platelets on ovarian cancer cell proliferation, docetaxel-induced apoptosis, and migration were evaluated using BrdU-PI flow cytometric and two-chamber chemotaxis assays. In vivo effects of platelet depletion on tumor growth, proliferation, apoptosis, and angiogenesis were examined using an …
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Bio-Inspired and Nanotechnology-Enabled Drug Delivery for Diabetes and Brain Cancer
… doxorubicin-loaded terpolymer nanoparticles and docetaxel-loaded terpolymer-lipid nanoparticles. Both nanoparticle formulations exhibited high drug loading efficiency, colloidal stability and low systemic toxicity. Parenteral administration of the nanoparticle formulations enabled delivery of …
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Costo-efectividad de la biopsia líquida para definir cambio farmacológico en cáncer de mama HER2 + avanzado en Colombia
… línea de tratamiento (Trastuzumab, Pertuzumab, Docetaxel y TDM1 respectivamente), resistencia , desenlaces, sensibilidad y especificidad de la prueba para detectar resistencia molecular. La efectividad se midió mediante AVAC y los costos fueron obtenidos de bases de datos de validez nacional, …
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Saffron extract and its active constituents as preventative and/or treatment agents for prostate cancer using in vitro and in vivo models
… cells into zebrafish and was validated using docetaxel as a known chemotherapy for prostate cancer. In conclusion, the optimized HPLC analytical method is an excellent tool for saffron quality evaluation. Saffron extract and its active constituents are considered good candidates as a …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
… cells selected for resistance to the taxane drug docetaxel (DTX). These cells also showed resistance to the taxanes cabazitaxel (CBZ) and paclitaxel (PTX), but not to the classical inducer of apoptosis TRAIL. Silencing LEDGF/p75 effectively sensitized taxane-resistant PC3 and DU145 cells to DTX …
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