Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 393 for “"Pharmacokinetics"”.
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Pharmacokinetics of methylamines
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1992.
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Pharmacokinetics of propofol in cats
… to occur in cats,19 however propofol’s pharmacokinetics have not been studied formally. The purpose of this study was to determine the pharmacokinetic behaviour of propofol after single intravenous injections. In comparison with man, the apparent central volume of distribution in …
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Plutonium pharmacokinetics and blood biochemistry
Since its discovery in the early 1940s the element plutonium has been seen by mankind as both an opportunity and a threat. As a radioactive nuclide plutonium presents health hazards in its handling and if mankind is to make the most of this element's potential benefits it is essential that these …
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A Meshless Approach to Computational Pharmacokinetics
<p>The meshless method is an incredibly powerful technique for solving a variety of problems with unparalleled accuracy and efficiency. The pharmacokinetic problem of transdermal drug delivery (TDDD) is one such topic and is of significant complexity. The locally collocated meshless method (LCMM) …
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Pharmacokinetics of Inhaled Clofazimine in Mice
… The purpose of this study is to evaluate in vivo pharmacokinetics (PK) of inhaled CFZ in healthy male Swiss Webster mice. Mice were divided in 2 major groups that received a single inhaled CFZ dose while the other received multiple inhaled CFZ doses twice weekly for 4 weeks followed by a washout …
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Modelling Renal Function in Drug Pharmacokinetics
Many drugs or their metabolites are eliminated from the body by the kidneys. Renal function is an important covariate to describe variability in drug clearance (CL) of renally eliminated drugs. This thesis explores the use of renal function in population pharmacokinetic (PK) and pharmacodynamic …
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Pharmacokinetics of neostigmine and pyridostigmine in man.
Most methods used for the extraction of quaternary amines in biological fluids have been based on ion-pair extraction techniques. In this study, a sensitive and selective chromatographic procedure is described to measure the concentration of pyridostigmine, neostigmine and their major metabolites …
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Challenges in the Pharmacokinetics of Therapeutic Proteins
… (FcRn) expression along with its effect on the pharmacokinetics of monoclonal antibodies (mAbs) during development.</p> <p>TMDD often well describes the pharmacokinetics of therapeutic proteins that have high specificity and affinity of binding to their target receptors. The target receptors can …
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PHARMACOKINETICS AND ORAL DELIVERY OF POLYMETHOXYLATED FLAVONES
… As ATE displayed both dose- and time-dependent pharmacokinetics, caution is needed in the medicinal applications of ATE and/or the herbs contain ATE. The results obtain from this PhD study will facilitate further medicinal explorations on TAN, ATE, and LTE.
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Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites
… is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). The reversible metabolism of pentoxifylline to …
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The Pharmacokinetics of Hexachlorobenzene in Male Beagles
The distribution, metabolism, and excretion of hexachlorobenzene were studied in male Beagle dogs. Distribution of HCB was determined in animals following single intravenous and multiple oral administrations in HCB. Metabolism and excretion of HCB were studied following single intravenous …
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Effect of rutaecarpine on caffeine pharmacokinetics in rats
… (in suspension) induction on caffeine pharmacokinetics upon 15 mg/kg intravenous bolus and 20 mg/kg oral caffeine doses. The MROD data showed that as early as 3 hours after oral rutaecarpine administration, CYP1A2 activity in the liver tissue is increased by almost 3-fold compared to …
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The pharmacokinetics of sodium monofluoroacetate (1080) in rabbits
Sodium monofluoroacetate (1080) is a pesticide widely used in New Zealand to control rabbits and possums. Very little is known about the in vivo behaviour of 1080 in target and non target species. This experiment was carried out to investigate the persistence and tissue distribution of 1080 in …
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Pharmacokinetics and Pharmacodynamics of Theophylline in Ruminating Calves
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987.
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Pharmacokinetics and Safety of Acetaminophen in Adult Horses
Due to the detrimental side effects of NSAID administration, such as gastrointestinal ulceration and renal papillary necrosis, there is a profound need for clinical pain relief in horses with long term orthopedic disease whereby gastrointestinal side effects are obviated. Acetaminophen is one of …
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Single dose pharmacokinetics of pimobendan in healthy horses
… intravenous administration in horses. The pharmacokinetics of oral pimobendan have not been investigated in horses. The hypothesis of this study was that pimobendan would be absorbed following oral administration to healthy adult horses and reach concentrations known to be therapeutic in …
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Studies on the Pharmacokinetics of Pinacidil in Healthy Volunteers
… in serum and urine. Using these methods, the pharmacokinetics of pinacidil were studied following intravenous and oral administration of the drug to healthy volunteers. Additional pharmacokinetic studies included the effect of food on the absorption of pinacidil and the effects of chronic …
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Pharmacokinetics of Aroclor 1254 Components in Sheep and Swine
Made available in DSpace on 2014-12-14T13:28:13Z (GMT). No. of bitstreams: 1 7606698.pdf: 1912787 bytes, checksum: 5a00f79b6a8cf6b058dc423d2891d616 (MD5) Previous issue date: 1975
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The Pharmacokinetics of Sulfathiazole in Sheep, Cattle and Swine
Made available in DSpace on 2014-12-14T13:28:16Z (GMT). No. of bitstreams: 1 7606824.pdf: 4803546 bytes, checksum: 2a534c09851764097fdf27128f3c6ed5 (MD5) Previous issue date: 1975
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