Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 429 for “"Pharmacokinetic"”.
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PREDICTION OF HUMAN SYSTEMIC, BIOLOGICALLY RELEVANT PHARMACOKINETIC (PK) PROPERTIES BASED ON QUANTITATIVE STRUCTURE PHARMACOKINETIC RELATIONSHIPS (QSPKR) AND INTERSPECIES PHARMACOKINETIC ALLOMETRIC SCALING (PK-AS)
<p>This research developed validated QSPKR and PK-AS models for predicting human systemic PK properties of three, preselected, pharmacological classes of drugs, namely opioids, β-adrenergic receptor ligands (β-ARL) and β-lactam antibiotics (β-LAs) using pertinent human and animal systemic PK …
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First-principle based pharmacokinetic modeling
… at the site of action is the hottest topic in pharmacokinetics (PK). In vitro-in vivo extrapolation (IVIVE) and physiological based pharmacokinetics (PBPK) models are two major PK prediction strategies. However, both IVIVE and PBPK models are considered as immature methodologies due to their …
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Optimizing pharmacokinetic studies utilizing microsampling
In Pharmacokinetic (PK) studies, inference is made on the absorption, distribution, metabolism and excretion (ADME) of an externally administered compound within the body. This is done by measuring the concentration of the compound in some form of bodily tissue (such as whole blood or plasma) at a …
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Investigation of surfactant-drug pharmacokinetic interactions
The oral administration route is a non-invasive, cost-effective route that is associated with high patient compliance, especially among the elderly and children. Excipients are frequently added to the active ingredient to contribute to a pharmaceutical formulation that is stable, easy to formulate …
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Investigations of Pharmacokinetic Challenges in Premature Infants
… a primary group receiving intensive care. Unique pharmacokinetic (PK) challenges—such as limited blood volume and frequency of blood sample collections, rapid growth and continuous developmental changes, complexity of pediatric studies as well as scientific, practical, and ethical concerns— lead …
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Design and Analysis of Pharmacokinetic and Pharmacodynamic Trials
Pharmacokinetic (PK) and Pharmacodynamic (PD) experiments play an important role in drug development. Statistical design determines the treatment allocation and time points for taking PK/PD measurements. A good design will reduce the cost and suffering of humans/animals used in the experiment and …
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METABOLIC AND PHARMACOKINETIC STUDIES OF BENZTROPINE AND TRIHEXYPHENIDYL
… have been used clinically for many years, their pharmacokinetics have not been previously determined. This seems to be due to the absence of sensitive and specific methods for assaying the drugs in biological fluids. Therefore, it was an analytical challenge to develop very sensitive and specific …
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Pharmacokinetic Behavior of Sulfamethazine in Sheep Following Intravenousadministration
Made available in DSpace on 2014-12-14T13:28:16Z (GMT). No. of bitstreams: 1 7606955.pdf: 3444446 bytes, checksum: dd5e28f4d00e7eb6cedb818fcf585f87 (MD5) Previous issue date: 1975
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Interspecies Pharmacokinetic Scaling and Metabolism of Alcohols and Glycols
… interspecies differences with respect to their pharmacokinetics (PK) arepoorly understood. The aim of this research was to use in-vivo and in-vitro approaches to compare and model the PK characteristics across various species.Methods: Appropriate published in-vivo studies (in different species) …
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Gentamicin-PMMA beads: a clinical, pharmacokinetic and toxicological study
Contains fulltext : mmubn000001_027398811.pdf (Publisher’s version ) (Open Access)
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Pharmacokinetic and neurochemical correlates of context-dependent behavioral sensitization
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Population pharmacokinetic and pharmacodynamic modelling to improve tuberculosis treatment
… mixed-effects modelling to evaluate the pharmacokinetics of first-line tuberculosis drugs isoniazid, pyrazinamide, and ethambutol in pregnancy. We assessed the pharmacokinetics and pharmacodynamics of pretomanid, clofazimine, and linezolid in African tuberculosis patients. Reassuringly, …
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Population pharmacokinetics and pharmacokinetic-pharmacodyamic modeling of antitubercular drugs
The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in 78 patients with tuberculosis were described using non-linear mixed effects modeling. Pharmacodynamic data was comprised of weekly sputum liquid culture (using mycobacterial growth indicator tubes) time to detection …
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Antimalarial activity and pharmacokinetic properties of new chemical entities
Includes abstract. Includes bibliographical references.
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Unravelling Variability in Antidepressant Outcomes using Pharmacogenetic and Pharmacokinetic Strategies
… depression. The second study focused on pharmacokinetic factors, leveraging data from the IRL-GRey study (N = 325), where older adults with depression were treated with venlafaxine (VEN) for 12 weeks. We adapted and improved a population pharmacokinetic model for VEN and its active …
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Pharmacokinetic and Pharmacodynamic Modelling to Advance Perioperative Anaesthesia and Analgesia
… of drugs when given alone and alongside others. Pharmacokinetic (PK) and pharmacodynamic (PD) models summarise complex drug relationships so they may be better understood and capitalised on. I report my investigations into using PKPD models to describe combined drug responses for applications in …
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Preclinical pharmacokinetic evaluation of novel antimalarial and antituberculosis drug leads
Preclinical pharmacokinetics relies on efficient and accurate screening to select clinical candidates from early leads. Poor pharmacokinetic interpretation can disadvantage drug discovery by promoting inadequate compounds and expelling potential drug candidates. Objectives of this project included …
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