The biosynthesis of brominated tyrosine metabolites by Aplysina fistularis

The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. ($U$-$\sp{14}$C) -L-Tyrosine, ($U$-$\sp{14}$C) -L-3-bromotyrosine, and ($U$-$\sp{14}$) -3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol and aeroplysinin-1, and (methyl-$\sp{14}$C) methionine was specifically incorporated into the O-methyl group of aeroplysinin-1. (Methyl-$\sp{14}$C) -O-methyltyrosine and (methyl-$\sp{14}$C) -3,5-dibromo-O-methyltyrosine and several putative nitrile precursors were not significantly incorporated into aeroplysinin-1.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Carney, John Ray

Contributors dc:contributor

• Rinehart, Kenneth L., Jr.

• Chemistry, Organic
• Agriculture, Fisheries and Aquaculture

Statement dc:rights

• Copyright 1990 Carney, John Ray

Language dc:language

eng

Identifier

AAI9114189
(UMI)AAI9114189

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20218