The biosynthesis of brominated tyrosine metabolites by Aplysina fistularis
The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. ($U$-$\sp{14}$C) -L-Tyrosine, ($U$-$\sp{14}$C) -L-3-bromotyrosine, and ($U$-$\sp{14}$) -3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol and aeroplysinin-1, and (methyl-$\sp{14}$C) methionine was specifically incorporated into the O-methyl group of aeroplysinin-1. (Methyl-$\sp{14}$C) -O-methyltyrosine and (methyl-$\sp{14}$C) -3,5-dibromo-O-methyltyrosine and several putative nitrile precursors were not significantly incorporated into aeroplysinin-1.
Chemistry, Organic, Agriculture, Fisheries and Aquaculture
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign