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(Methyl-$\\sp{14}$C) -O-methyltyrosine and (methyl-$\\sp{14}$C) -3,5-dibromo-O-methyltyrosine and several putative nitrile precursors were not significantly incorporated into aeroplysinin-1.","abstract_html":"The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. ($U$-$\\sp{14}$C) -L-Tyrosine, ($U$-$\\sp{14}$C) -L-3-bromotyrosine, and ($U$-$\\sp{14}$) -3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol and aeroplysinin-1, and (methyl-$\\sp{14}$C) methionine was specifically incorporated into the O-methyl group of aeroplysinin-1. (Methyl-$\\sp{14}$C) -O-methyltyrosine and (methyl-$\\sp{14}$C) -3,5-dibromo-O-methyltyrosine and several putative nitrile precursors were not significantly incorporated into aeroplysinin-1.","abstract_has_math":true,"creators":["Carney, John Ray"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Rinehart, Kenneth L., Jr."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:32:36Z","date_published":"2011-05-07T12:32:36Z","updated_at":"2026-07-22T22:25:15Z","subjects":["Chemistry, Organic","Agriculture, Fisheries and Aquaculture"],"languages":["eng"],"rights":["Copyright 1990 Carney, John Ray"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9114189","(UMI)AAI9114189"],"render_values":[{"text":"AAI9114189","href":null,"code":true},{"text":"(UMI)AAI9114189","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20218","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Rinehart, Kenneth L., Jr."]},{"key":"dc:creator","label":"Author","values":["Carney, John Ray"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:32:36Z","10000-01-01","1990"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Organic","Agriculture, Fisheries and Aquaculture"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1990 Carney, John Ray"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9114189","(UMI)AAI9114189","http://hdl.handle.net/2142/20218"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. 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($U$-$\\sp{14}$C) -L-Tyrosine, ($U$-$\\sp{14}$C) -L-3-bromotyrosine, and ($U$-$\\sp{14}$) -3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol and aeroplysinin-1, and (methyl-$\\sp{14}$C) methionine was specifically incorporated into the O-methyl group of aeroplysinin-1. (Methyl-$\\sp{14}$C) -O-methyltyrosine and (methyl-$\\sp{14}$C) -3,5-dibromo-O-methyltyrosine and several putative nitrile precursors were not significantly incorporated into aeroplysinin-1.","Made available in DSpace on 2011-05-07T12:32:36Z (GMT). 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