Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Marine sponge."”.
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Adaptive Tolerance to Ocean Acidification in the Marine Sponge: Chondrilla nucula
… imbalances in soft-bodied animals such as sponges has been grossly overlooked. Furthermore, many studies on ocean acidification have not considered the elevated temperatures that are predicted to accompany future climate change conditions. Sponges are crucial components to coral reef …
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Genomics approaches to exploit the biotechnological potential of marine sponge-derived Streptomyces spp. isolates
… diverse environmental niches, such as marine ecosystems, mangroves, and symbiotic communities of insects and sponges, resulting in the discovery of a variety of previously unidentified compounds of pharmacological interest; including those isolated from marine-derived Streptomyces …
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Synthesis and Chromatography of [RuCp]+-labelled Diaryl Ether Peptoids as Precursors of the Bastadins from the Marine Sponge Ianthella basta
The bastadins are bromo tyrosine-derived tetrapeptides linked via two diaryl ether and two amide bonds. The synthesis of the ruthenium-labelled peptoids in this thesis uses the nucleophilic attack of phenolates on [RuCp]+-complexed chloroarenes to form diaryl ethers in the preparation of …
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Part I. The Acyl-Tunichlorins: A New Class of Nickel Chlorins Isolated From the Caribbean Tunicate Trididemnum Solidum. Part II. Cytotoxic Constituents of the Sponges Stylissa Carteri and Petrosia Sp. Part III. Electrospray Tandem Mass Spectrometry Studies
… a new polyacetylene was identified in the marine sponge Petrosia sp.
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The biosynthesis of brominated tyrosine metabolites by Aplysina fistularis
… of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. ($U$-$\sp{14}$C) -L-Tyrosine, ($U$-$\sp{14}$C) -L-3-bromotyrosine, and ($U$-$\sp{14}$) -3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol and aeroplysinin-1, and …
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Constituents of Aplysina Fistularis
The constituents of three species of a marine sponge, Aplysina fistularis, were examined by gas chromatography/mass spectrometry (GC/MS), high pressure liquid chromatography (HPLC) and classical fractionation and purification procedures. GC/MS indicated that many brominated tyrosine metabolites …
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Structural and Synthetic Studies of Bioactive Natural Products
… and comparison to the known literature data. Two marine extracts were also investigated. The pyridoacridine alkaloids, amphimedine and neoampimedine, were isolated from the marine sponge Petrosia sp., and three bromo-tyrosine alkaloids were isolated from the marine sponge Porphyria flintae. The …
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Marine bacteria as a source of polyester-degrading enzymes with biocatalytic potential
… few PET-hydrolyzing enzymes were reported from marine environments, an aspect which we hoped to expand upon. In chapter 2, activity screening and genome mining of marine bacterial isolates led to the identification of a polyesterase, BgP, from a deep-sea, marine sponge-derived Brachybacterium …
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Total synthesis of ulocladol A and analogues alternariol 0-methyl ether and alternariol
… against the enzyme Lck. It was isolated from the marine sponge Callyspongia vaginalis in 1999. Prior to the commencement of this project there had been three reported syntheses of ulocladol A, all of which started from intermediates prepared in the synthesis of graphislactones C and D. The routes …
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Análise química preliminar de extratos de Caulerpa mexicana, Bryopsis pennata, Vryothamion triquerum, Hypnea musciformes e Ircina felix e avaliação das atividades antifúngica e antibacteriana.
The products from marine origin are today the sourc e of study in many research groups, because they can lead to secondary metaboli tes with a large biological potential for the drug development. The algae Caulerpa mexicana, Bryopsis pennata, Hypnea musciformes, Bryothamnion triquetrum, and the …
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Advancing the Preclinical Development of Secondary Metabolites from Cacospongia mycofijiensis for the Treatment of Cancer
<p>The marine sponge <em>Cacospongia mycofijiensis</em> from the Indo-Pacific has proven to be a source of structurally diverse secondary metabolites that are biologically active against a variety of distinct targets. Current interest in the secondary metabolites of <em>C. mycofijiensis …
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Synthesis of Novel Glycolipid Agonists of the Protein CD1d
… \(\beta\)GalCer), originally isolated from a marine sponge, is a powerful agonist of CD1d capable of triggering an immune response that results in the proliferation of a range of regulatory cytokines, including IFN-\(_y\) (Th1), as well as IL-4 (Th2). This mixed cytokine response (i.e. Th1 and …
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The Synthesis-Enabled Stereochemical Elucidation of the Marine Natural Products Hemicalide and Phormidolide A
… structural complexity and biological activity of marine natural products have made them attractive targets for synthetic chemists. In cases where their relative and/or absolute configuration is unknown, total synthesis becomes a powerful method to enable their structural elucidation, as …
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Novel approaches to the control of infectious diseases
… infectious diseases, several terrestrial and marine macro- and microorganisms were investigated. Several bioactive molecules, presented below, were isolated from these natural products. The mass-screening of dozens of marine Actinomycetes was completed and several Streptomyces with interesting …
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Total synthesis of polycyclic natural products : synthetic studies on (+)-ineleganolide, (–)-sinulochmodin C, verrillin hydrate, and aleutianamine.
… products are a broad and diverse class of marine and terrestrial natural products that have captured and held the attention of the synthetic and biomedical communities for nearly three decades. Their daunting polycyclic molecular architectures, coupled with promising biological activities …
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Synthetic Studies Towards the Gombaspiroketals and a Cobalt-Catalysed Epoxide Olefination
… which were isolated from a South Korean marine sponge (Clathria gombawuiensis) in 2014. The gombaspiroketals belong to a family of sesterterpenoids derived from the alotane skeleton, some of which exhibit potent and varied bioactivities. Recent total syntheses of alotane natural products …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… A synthetically derived glycolipid from the marine sponge, <em>Agelas mauritianus</em>, alpha-Galactosylceramide (α-GalCer) potently activates iNK-T cells. Within a few hours after activation, iNK-T cells produce high quantities of T<sub>H</sub>1 and T<sub>H</sub>2 type cytokines, thus shape …
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Total Synthesis of the Unique Pederin Family Member Psymberin & Chemical Studies Toward Saliniketal Family Members: Saliniketal a, Salinisporamycin and Rifsaliniketal
… Psymberin was isolated from a psammoncinal sponge possessing an unprecedented differential cytotoxicity profile, whereas irciniasatin A was isolated from the marine sponge Ircinia ramose showing potent growth-inhibitory properties against solid human tumor cell lines. The first chapter …
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New cytotoxic natural products from North-Eastern Pacific marine invertebrates
… into the chemistry of four species of marine invertebrates which were found to produce cytotoxic crude extracts (ED50 against the L1210 murine leukemia cell line 5 30 pg/mL) led to the isolation of nine new and eleven previously known secondary metabolites. The structures of the novel …
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