Ongoing large-scale connectome dynamics across neural timescales and their moment-to-moment impact on perception

Functional connectivity (FC) is a critical mechanism for cross-areal neural communication required for cognition. It is established that the large-scale spatial pattern of FC, when estimated over a relatively long time interval (known as the static functional connectome), relates to behavior and mental illnesses. Importantly, the spatial organization of the functional connectome manifests constant reconfigurations, likely supporting the malleable nature of human cognition (Preti et al., 2017). Although recent studies have reported associations between the connectome reconfigurations and human cognition, there is little known about the spatio-temporal principles that may govern the connectome reconfigurations, especially in the multi-faceted recordings of electrophysiology. Particularly, this question becomes more critical considering that neural population-level processes unfold across a wide range of timescales, from infraslow fluctuations as observed in functional Magnetic Resonance Imaging (fMRI) to high gamma oscillations as recorded in intracranial EEG. In this document, I will first present my findings on spatio-temporal principles that govern the connectome and its dynamic reconfigurations (chapters I and II), following with a study that establishes the behavioral relevance of connectome dynamics to moment-to-moment perceptual outcomes (Chapter III). At the end, I wrap up all our findings in the form of a general discussion (Chapter IV).

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Psychology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2024

Author dc:creator

• Mostame, Parham

Contributors dc:contributor

• Sadaghiani, Sepideh
• Gratton, Gabriele
• Lemieux, Louis
• Koyejo, Sanmi
• Barbey, Aron Keith

• Fmri
• Eeg
• Connectome
• Functional Connectivity
• Ecog
• Intracranial
• Multiplex
• Timescales
• Fc
• Ongoing Fc
• Intrinsic Fc
• Spontaneous Functional Connectivity
• Perception

Statement dc:rights

• Copyright 2024 Parham Mostame

Language dc:language

en, eng

Handle dc:identifier

https://hdl.handle.net/2142/124258

OAI record oai:identifier

https://www.ideals.illinois.edu/oai-pmh?verb=GetRecord&metadataPrefix=etdms&identifier=oai%3Awww.ideals.illinois.edu%3A2142%2F124258