Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 583 for “"Fc"”.
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The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa
FcyRIIa is an activatory receptor and contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain, involved in the initiation of signalling events. There is now strong evidence from transgenic mouse models and human genetic susceptibility studies that implicate …
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Localization of FC Receptors on Murine Spermatozoa.
Studies on the localization of acrosomal enzymes have shown that a heat stable component in non-immune serum binds to the acrosomal region of spermatozoa of a number of species (Weil and Finkler, 1959; Edwards, 1960). Beck et al. (1962) demonstrated by immunofluorescent techniques that this serum …
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Rapid screening of PEM FC cathode catalysts
… for proton exchange membrane fuel cell (PEMFC) is the lack of fast high-throughput testing methods. Fast screening techniques enable a large number of catalysts to be tested in a relatively short time under the same conditions.<br/><br/>This project was focused on developing systems for …
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Interrogation and Manipulation of the IGG FC Glycan
… of a given antibody's fragment crystallizable (Fc) domain, which interfaces with cells of the immune system. Often considered a constant region, the immunoglobulin G (IgG) Fc protein backbone and conserved N-linked glycan combine to introduce structural diversity in IgG molecules that in turn, …
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Subject-Specificity of SC-FC in the Human Brain
… of the brain, whereby functional connectivity (FC) describes the temporal relationships of neural activity between regions. The present body of work aims to understand individual SC and FC and how they are linked to behaviour, and to compare and combine SC and FC at the individual level. Study 1 …
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Analýza a optimalizace řízení fotbalového klubu FC Kyjov 1919 o.s.
… Praktická část je zaměřena na fotbalový klub FC Kyjov 1919, který je detailněji analyzován od historie až po současnost. V návrhové části jsou na základě posbíraných dat z dotazníkového šetření, řízeného rozhovoru, vlastního pozorování a SWOT analýzy sestaveny návrhy a doporučení.
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… of my research project was to characterize Fc receptor expression in epithelial cell models of the lower female genital tract with a particular focus on the neonatal Fc receptor (FcRn). Fc receptors are a large family of proteins that bind to the Fc region of immunoglobulins (Igs) and …
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Development of an internally heated FC-CVD reactor for CNT synthesis
… as floating catalyst chemical vapor deposition (FC-CVD) which generates some of the highest quality CNTs directly into the final form from the reactor. However, it was found that FC-CVD is not readily scalable with a low production rate per volume of reactor (< 2 …
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The Development of Methods for Generating Fc-Conjugates and Antibody-Drug Conjugates
… and bioconjugation of small molecule linkers to Fc protein followed by post-functionalisation with therapeutic peptides to generate Fc-peptide conjugates. Many biologically active proteins and peptides suffer from an extremely short plasma half-life, which limits their therapeutic potential. A …
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The Fc Orth(SA) final examination. How effective is the written component?
… College of Orthopaedic Surgeons of South Africa [FC Orth(SA)] and to assess the correlation between the written component with the clinical and oral component. Methods: Results of candidates who participated in the FC Orth(SA) final examination during a 12-year period from March 2005 through to …
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Transepithelial transport of nanoparticles targeted to the neonatal Fc receptor for oral delivery applications
… efficient oral delivery of NPs. The neonatal Fc receptor (FcRn) mediates IgG antibody transport across epithelial barriers. It was discovered as the receptor in the neonatal intestine that transports IgG in breast milk from mother to offspring. However, FcRn is expressed into adulthood at …
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Investigating the novel interaction between hERG and the Fc region of IgG and its consequences
… hERG current (IhERG) by 23-56%, with the Fc region in particular identified to solely convey these effects through binding to the S5-pore linker. Moreover, we demonstrate that a previously overlooked immunoreceptor tyrosine-based inhibitory motif (ITIM) within the C-terminus of hERG is …
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Targeting the Neonatal Fc Receptor, FcRn, to Treat Autoimmunity and Elucidation of Sites of FcRn Function
The neonatal Fc receptor, FcRn, is expressed in many different cell types and serves several functions, some of which are cell type-specific. A function common to most cell types that express this receptor is salvage of IgG from cellular degradation which is responsible for the long in vivo …
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Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia
… targeting this receptor, which makes use of an Fc gamma receptor scaffolding mechanism to interact with its target. This mechanism is specific to antibodies targeting cells of the hematopoietic lineage, which possess Fc gamma receptors. It has been described in the literature as antigenic …
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Quantitative Chemical Analysis Throughout the FC CVD Process as a Route to Reliable Fibre Production and Research
… Floating Catalyst – Chemical Vapour Deposition (FC-CVD) process has been developed at Cambridge University for 14 years by the Macromolecular Materials Laboratory (MML) group. Since then research has focused on lab-scale processes and fibre property optimisation. Continued research has been …
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