University of Tennessee Health Science Center
Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man
Abstract
dc:description.abstract<p>Cancer and vascular disease are the two most predominant causes of mortality in the United States. Potential regulatory mechanisms for these two diseases have consumed research interests. Tetraspanins are cell surface proteins that organize the cell membrane. Cellular membrane organization is a prerequisite for cellular signaling to occur. Deregulation of cellular signaling often precedes the formation of cancer or vascular disease phenotypes. This insinuates the necessity to understand how tetraspanins contribute to membrane organization and subsequent downstream signaling. This work examines tetraspanin CD9 contributions in a model of cancer cell invasion and vascular cell contraction. The findings presented here demonstrate that CD9 expression promotes human fibrosarcoma cell invasion by upregulating matrixmetalloproteinase-9 expression. These effects were dependent upon an extracellular region of CD9 and involved the presence and activity of the epidermal growth factor receptor. In the vascular cell model, CD9 elicited the actin arrangement and contraction of human aortic smooth muscle cells in a RhoA dependent manner. Taken together these provide insight on how tetraspanins regulate diverse cellular phenotypes.</p>
Degree
thesis:*- Name thesis:degree_name
- Doctor of Philosophy (PhD)
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Biomedical Sciences
- Year dc:date.available
- 2013
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Herr, Michael James, II
- Contributors dc:contributor
-
- Lisa K. Jennings, Ph.D.
Subjects
dc:subject × 9Identifiers
dc:identifier.*- Repository record dc:identifier
- https://dc.uthsc.edu/dissertations/126
- OAI identifier oai:identifier
- oai:dc.uthsc.edu:dissertations-1115