Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 148 for “"Cellular Signaling"”.
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Metabolic Regulation of Cellular Signaling
… we tested the ability of aberrant glucose signaling to regulate the CaM-binding protein PI3K. We found that addition of G6P, mimicking aberrant glucose metabolism, or CoA to X. laevis egg extracts activated Akt in a phosphatidylinositol 3-kinase (PI3K), phosphoinositidedependent protein …
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Investigations into cellular signaling through optogenetics and nanotechnology
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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The role of 4-hydroxynonenal in cellular signaling mechanisms
One of the critical steps involved in cellular oxidative stress is the peroxidation of membrane lipids. The downstream effects of the autocatalytic lipid peroxidation (LPO) cycle are widespread and involve several processes. Using lens epithelial cells (HLE B-3) and retinal pigment epithelial cells …
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Identification of cellular signaling events dysregulated in Huntington’s disease.
… pathways in HD result from aberrant kinase signaling. Protein phosphorylation is catalyzed by a class of enzymes called kinases, the cellular complement of which is referred to as its kinome. The kinases responsible for driving the fate of phosphoproteomes are central to elucidating various …
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Cellular Signaling in Development of the Cochlear Tonotopic Gradient
… The tuning results from coordination of many cellular and extracellular features. Seeking the mechanisms that orchestrate those features and govern the tonotopic gradient, we used expression microarrays to identify genes differentially expressed between the high and low-frequency regions of …
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Tools for investigating cellular signaling networks by mass spectrometry
… study of Epidermal Growth Factor Receptor (EGFR) signaling and phenotype prediction. The quantity of proteomic mass spectrometry data available from a single analysis has increased exponentially as new generations of instruments become quicker and more sensitive. This deluge of data leaves many …
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Protein/Peptide Recognition Modules in Cellular Signaling and HIV Pathogenesis
… that Nef functions as an adaptor to subvert cellular signaling processes for the benefit of the invading virus.</p>
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Design for selective remote control of cellular signaling using magnetic nanoparticles
… the structure and dynamics of the mammalian cellular signaling and the nervous system opens up the chances to induce tissues, organs, or organisms to function in a coordinated way. Consequently, extensive research and efforts have rapidly developed strategies for rationally manipulating …
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A constraint optimization framework for discovery of cellular signaling and regulatory networks
Cellular signaling and regulatory networks underlie fundamental biological processes such as growth, differentiation, and response to the environment. Although there are now various high-throughput methods for studying these processes, knowledge of them remains fragmentary. Typically, the majority …
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Bioimage informatics for understanding the effects of chemotherapy on cellular signaling, structure, and function
… quantitative characterization of molecular signaling pathways and changes in cancer cell phenotypes induced by chemotherapy through the use of in vitro model systems would expand our understanding of drug mechanisms and provide for putative strategies to counteract drug-induced cancer …
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GraphCrowd: Harnessing the Crowd to Lay Out Graphs with Applications to Cellular Signaling Pathways
… out salient features. GraphCrowd focuses on signaling networks, which connect proteins that represent a cells response to external signals. Treating network layout as a design problem, GraphCrowd explores the feasibility of leveraging human computation via crowdsourcing to create simplified …
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Molecular and Cellular Signaling Mechanisms Elucidating Aldose Reductase Mediated Ischemia-Reperfusion Injury in the Myocardium
… dissertation serves to analyze the molecular and cellular signaling mechanisms by which aldose reductase (AR) contributes to ischemia/reperfusion (I/R) injury, specifically in the myocardium. It provides a comprehensive overview of the pathophysiology associated with acute coronary syndromes, the …
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Effects of physical activity levels and nutritional intake on skeletal muscle protein turnover and cellular signaling
… for skeletal muscle, though their specific cellular mechanisms remain largely unknown. Studies were designed to examine the mammalian target of rapamycin (mTOR) muscle hypertrophy pathway in conditions of differing physical activity levels, to determine the effects of low and high …
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Visualization of cellular signaling by fluorescence resonance energy transfer in response to biochemical and mechanical microenvironments
… have a great impact on a variety of cellular processes including cell adhesion and migration. While substantial progress has been made toward the understanding of how these factors regulate many cellular functions, it remains elusive on the molecular mechanism by which stem cells …
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Design of a Website and Signaling Map Template Acting as a Database Interface and Providing a Visual Explanation of Cellular Signaling Networks an Their Operative Components
… and describe the design of a website and signaling map template wherein the maps are standardized, expandable in detail, and act as a database interface while providing a visual explanation of cellular signaling networks and their operative components. This template was designed to provide …
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Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man
… proteins that organize the cell membrane. Cellular membrane organization is a prerequisite for cellular signaling to occur. Deregulation of cellular signaling often precedes the formation of cancer or vascular disease phenotypes. This insinuates the necessity to understand how tetraspanins …
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Study of cellular mechanisms of inflammation and the involvement of mast cells in disease
… (CFMA), beyond the study of fundamental cellular biophysics and toward applications investigating the cellular signaling networks in inflammation. From an analytical perspective, the inflammatory response presents several technical challenges. The inherent complexity of the immune system …
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Caged phosphopeptides and phosphoproteins : agents in unraveling complex biological pathways
Within cellular signaling, protein phosphorylation is the post-translational modification most frequently used to regulate protein activity. Protein kinases and phosphoprotein phosphatases generate and terminate these phosphoryl signals, respectively. Chemical approaches for studying protein …
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Analysis and Interpretation of Complex Biological Signal Transduction Networks
Cellular signaling is a complex system of biological communication that coordinates cellular activities via biochemical reactions. The passing of an extracellular signal across a cell membrane to intracellular signaling molecules is referred to as signal transduction. Signals transduced across a …
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