Global ETD Search
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Showing 1 to 20 of 28 for “"Tetraspanin"”.
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Characterization of the Tetraspanin protein Tspan18
Tetraspanins are a superfamily of four-transmembrane proteins. They associate laterally with one another and with other transmembrane proteins to form membrane microdomains, in which associated proteins are regulated. Tetraspanins regulate diverse processes such as cell signalling and fusion, …
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A new view on the tetraspanin web
Contains fulltext : 159467.pdf (Publisher’s version ) (Open Access)
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Molecular Mechanism of Tetraspanin CD9 Mediated Cell Motility
<p>CD9, a member of the tetraspanin superfamily of proteins participates in the regulation of cell adhesive functions such as cell migration. The mechanisms underlying CD9 mediated cell migration are not known. In the current study, we investigated the molecular basis for the CD9 promoted cell …
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Investigations of tetraspanin functions using large extracellular loops
… describes our characterization of a specific tetraspanin domain: the large extracellular loop (LEL). Tetraspanins are involved in cellular migration, adhesion, and metastasis, sperm-egg fusion, and viral infectivity. The large extracellular loop domain is the major extracellular domain of …
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The Tetraspanin CD9 Localizes to Platelet-Platelet Contacts and Regulates Thrombus Stability
<p>CD9, a member of the tetraspanin family, is highly expressed on platelets (50,000-80,000 copies per platelet). Tetraspanins have been implicated in modulation of integrin function, and it is hypothesized that CD9 will modulate GPIIb-IIIa, the major platelet integrin.</p> <p> The association …
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DISSECTING THE ROLE OF THE TETRASPANIN MS4A4A IN MODULATING MACROPHAGE PLASTICITY AND FUNCTION
… cell types and structural similarities to tetraspanins, including the ability to interact with and modulate the activity of various immunoreceptors, such as pattern recognition receptors (PRRs) and Ig receptors. MS4A4A is selectively expressed by macrophages, and its expression is …
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Tetraspanin KAI1/CD82 inhibits cell migration-related cellular events via reorganizing actin network
<p>To determine how tetraspanin KAI1/CD82, a tumor metastasis suppressor, inhibits cell migration, we assessed which motility-related cellular events are altered by KAI1/CD82 and how KAI1/CD82 regulates these events. We found that KAI1/CD82-overexpressing cancer cells exhibit various morphologies …
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Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man
… two diseases have consumed research interests. Tetraspanins are cell surface proteins that organize the cell membrane. Cellular membrane organization is a prerequisite for cellular signaling to occur. Deregulation of cellular signaling often precedes the formation of cancer or vascular disease …
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THE ROLE OF TETRASPANIN-8 IN ASTROCYTE ELEVATED GENE-1 MEDIATED PROGRESSION OF HEPATOCELLULAR CARCINOMA
… identified the small transmembrane protein, tetraspanin8 (TSPAN8) as a downstream of AEG-1. TSPAN8 belongs to the family of TETRASPANINS with the characteristic of crossing the membrane four times, and regulating a wide range of cellular phenomena. TSPAN8 is implicated in metastasis and is …
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The role of tetraspanin pretein CD63 in humna immunodeficiency virus type 1 infection and replication
Human Immunodeficiency Virus (HIV) infection typically involves interaction of Env with CD4 and a chemokine coreceptor, either chemokine (C-C motif) receptor 5 (CCR5) or chemokine (C-X-C motif) receptor (CXCR4). Other cellular factors supporting HIV replication have recently been characterized. …
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Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins
Tetraspanins are a superfamily of glycoproteins that function as ‘organisers’ of membranes by clustering with each other to form tetraspanin-enriched microdomains, into which certain other receptors and signalling proteins are recruited and regulated. Tetraspanin microdomains have been implicated …
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Expression of Tetraspanin Markers in Benign Prostate Hyperplasia and Prostate Cancer // Експресия на тетраспанинови маркери при доброкачествена хиперплазия и карцином на простатната жлеза
През последните години бяха постигнати значителни успехи в по-прецизното стратифициране на пациентите с простатен карцином с цел избягване на ненужни терапевтични интервенции или недостатъчно агресивно лечение при привидно нискорискови тумори. Независимо от постигнатите резултати в изясняването на …
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Novel findings on cellular trafficking and targeting for granule storage of neutrophil elastase, a multifunctional effector molecule of innate immunity
… An association was demonstrated between the tetraspanin CD63 and proNE upon coexpression in COS cells. Furthermore, depletion of CD63 in a promyelocytic cell line (achieved by RNA interference or a CD63 mutant) caused reduced processing of proNE into mature NE and reduced constitutive …
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CD151 Reinforces Vascular Stability by Balancing Endothelial Cell Adhesion and Cytoskeletal Tension
<p>Tetraspanin CD151 is highly expressed in endothelial cells and regulates pathological angiogenesis. However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. We observed that CD151 is required for the maintenance of …
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TUMOR-PROMOTING FUNCTION AND MOLECULAR REGULATION OF TSPAN8 IN LIVER CANCER
… plasma membrane protein that belongs to the tetraspanin superfamily. In this study, we found that TSPAN8 is highly expressed in cholangiocytes but absent in hepatocytes in the healthy liver. Remarkably, its expression is robustly switched on in transformed hepatocytes in two liver cancer …
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The Role of the YXXΦ Motif in CD82 Trafficking and Function
<p>CD82, a tetraspanin, is a tumor metastasis suppressor. Tetraspanins are membrane spanning proteins that play critical roles in diverse biological and pathological processes, e.g., the regulation of cancer metastasis. CD82 is ubiquitously expressed in various types of tissues, but its expression …
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Quantitative analysis of subcellular biomechanics and mechanotransduction
… mutant form of the integrin-associated molecule tetraspanin CD151 revealed that CD151 plays a key role in selectively strengthening α6βl integrin-mediated adhesion to laminin-1. We then studied cytoplasmic behavior using cells from mice with an αB-Crystallin mutation (R120G) that causes …
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Extracellular matrix protein receptors in Drosophila melanogaster
… names, and include CD81, a member of the tetraspanin family, ILK, integrin-linked kinase, and CD98hc, a type II transmembrane glycoprotein which is the heavy chain of a multi-protein complex. In this work, the mutant phenotype of CD98hc is larval lethal and not temperature sensitive. …
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INVESTIGATING THE ROLE OF EXTRACELLULAR VESICLES AND GLYCOSYLATION IN CANCER METASTASIS
… sEVs but with nuanced specificity attributed to tetraspanin composition. Additionally, other glycosylated targets, as recognised by TL and LCA, show increased abundance in breast cancer cell-derived sEVs. Moreover, the diagnostic capability of these lectins and EpCAM in distinguishing …
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Investigating the role of extracellular vesicles and glycosylation in cancer metastasis
… sEVs but with nuanced specificity attributed to tetraspanin composition. Additionally, other glycosylated targets, as recognised by TL and LCA, show increased abundance in breast cancer cell-derived sEVs. Moreover, the diagnostic capability of these lectins and EpCAM in distinguishing …
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