Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 569 for “"Neoplasms"”.
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A study of neoplasms
… local conditions. Because spontaneous cases of neoplasms in dairy cattle do not occur with any regularity, other phases of cancer research were instituted for investigation during the interval between cases. From the results of the previously described experiments, the following conclusions were …
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The molecular pathogenesis of myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological stem cell<br/>malignancies characterised by proliferation of one or more cells of the myeloid lineage. The molecular<br/>investigation of MPN was revolutionized in 2005 by the finding that approximately 95% of cases …
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Determinants of clinical phenotype in myeloproliferative neoplasms
Background: Myeloproliferative neoplasms, (MPNs) such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates. The genomic characterization of patients with myeloproliferative neoplasms offers the potential for personalized …
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Bone Marrow Charges in Individuals With Extramedullary Malignant Neoplasms
… marrow of patients with extramedullary malignant neoplasms was inspired by the finding of bronchogenic carcinoma in an individual, who, during life, had a severe anemia and a marked leukemoid blood picture with eosinophilia. Diagnostic procedures and therapy were directed toward the clinical …
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… frequent, or therapeutically challenging neoplasms, and to evaluate their suitability as druggable candidates for targeted therapy and as comparative models for human cancer. The approach combined immunohistochemistry, genetic analyses, and exploratory in vitro studies, focusing on …
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Nipt Results Indicative of Maternal Neoplasms: Genetic Counselors' Preferences and Attitudes
… towards NIPT’s ability to indicate maternal neoplasms. Despite 95% of this cohort being aware of this possibility and 77% reporting that they would disclose these results if indicated, only 29% routinely communicate this possibility to their patients in a pre-test setting. Management …
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Mutant Kras Alters Extracellular Vesicle Microrna Sorting In Pancreatic Cystic Neoplasms
<p>Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers by organ site with a 5-year survival rate of just 10.8%. This is largely because most patients do not experience symptoms until the disease has already metastasized. The best hope to cure PDAC is surgery, which can only be …
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New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
… primary myelofibrosis, two myeloproliferative neoplasms (MPNs) characterised by megakaryocyte hyperplasia. Despite the large body of research built around CALR mutations, many aspects of the oncogenic mechanisms of CALR in MPNs remain unanswered. This investigation aims to investigate whether …
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An Assessment of Universal Tumour Associated Antigens in Primary Liver Neoplasms
Rates of primary liver cancer are increasing in the Western world, a fact yet to be reflected in research with most currently undertaken in Asia. Whilst here in the UK, during a diagnostic and therapeutic workup within the NHS, surgically resected tumours are routinely kept in storage for up to …
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Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) commonly result from the acquisition of somatic mutations affecting the Janus kinase 2 (JAK2) (such as JAK2<sup>V617F</sup>) or the multi-functional protein CALR (such as CALR<sup>Ins5</sup> and CALR<sup>Del52</sup>), causing the constitutive activation of signal …
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Evolution of the genome in myeloproliferative neoplasms and the methylome in blood
… to genomic evolution in myeloproliferative neoplasms (MPNs) and identify changes in the methylome of blood with age and in the context of driver mutations. In the first study, serial sequencing of bulk samples from 30 patients with MPN coupled with clinical data show that clonal evolution is …
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Molecular and functional studies of ABL1 and FGFR1 fusion oncogenes in myeloproliferative neoplasms
… fusion genes underlying the myeloproliferative neoplasms chronic myeloid leukemia (CML) and the 8p11-myeloproliferative syndrome (EMS). CML and EMS are both myeloproliferative disorders with an initiating, relatively indolent, chronic phase that after some time progresses into acute myeloid or …
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A nested case-control study of lung cancer and central nervous system neoplasms among chemical workers
… between lung cancer and central nervous system neoplasms (CNSN) and employment at a dye and resin manufacturing plant. The study includes 51 lung cancer and 11 CNSN cases who were members of a cohort previously examined in a retrospective follow-up study. Two and four controls were selected for …
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SYNTHESIS OF a,ß-UNSATURATED-1,3-DIKETONES AND RELATED MANNICH BASES FOR EVALUATION AGAINST VARIOUS NEOPLASMS
… especially those which have greater toxicity for neoplasms than normal tissues. Mannich bases have been found to display a wide range of biological activities. Earlier workers from these laboratories have established the potentiality of some of these compounds as antineoplastic agents. Based on …
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Resection of biliary mucinous cystic neoplasms: Study of a single institutional cohort and a literature review
Background: Biliary mucinous cystic neoplasms (BMCNs) are uncommon neoplastic septated intrahepatic cysts which are often incorrectly diagnosed and have the potential for malignant transformation. Aim: The aim of this study was to assess the outcome of surgical resection of BMCNs. Methods: Data …
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Risk of Second Malignant Neoplasms Following Proton Arc Therapy and Volumetric Modulated Arc Therapy For Prostate Cancer
<p>The risk of second malignant neoplasms (SMNs) following prostate radiotherapy is a concern due to the large population of survivors and decreasing age at diagnosis. It is known that parallel-opposed beam proton therapy carries a lower risk than photon IMRT. However, a comparison of SMN risk …
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Exploring the role of the arginine-methylation writer-reader pair PRMT5/SND1 in JAK2-mutant myeloproliferative neoplasms
<p>Myeloproliferative neoplasms (MPNs) are a hematopoietic disease characterized by hyperproliferation of cells of the myeloid lineage for which current therapeutic options are limited. Discovered in 2005, the JAK2V617F mutation is the most common driver mutation in BCR-ABL negative MPNs, resulting …
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