Novel protocols to induce tolerance to solid organ transplants

Dendritic cells (DCs) are the sentinels of the immune system. They mature at the encounter of the appropriate stimuli or danger signals, which induce them to perform pro-inflammatory antigen presentation to naïve and memory T cells, resulting in inflammation. Remaining in an immature state however, DCs acquire a tolerogenic phenotype. When activated by TLR ligands, DCs undergo metabolic re-programming and switch to TBK1/IKKe/AKT-induced glycolysis at the early activation phase, which is sustained due to nitric oxide (NO)-mediated inhibition of mitochondrial metabolism at the later activation phase. Targeting DC activation in the view of promoting less activated or tolerogenic DCs could be an approach to reduce or abrogate inflammation in settings such as solid organ transplant rejection or in autoimmune diseases such as systemic lupus erythematosus (SLE). In this thesis, we present data pertaining to three different approaches for targeting DC activation including 1) the use of ethyl p

Grantor dc:publisher

Temple University. Libraries

Year dc:date.issued

2016

Author dc:creator

• Chakhtoura, Marita

Advisor dc:contributor.advisor

• Gallucci, Stefania

Committee members dc:contributor.committeemember

• Monestier, Marc
• Eisenstein, Toby K.
• Caricchio, Roberto
• Koch, Walter J.

• Immunology
• Medicine
• Dendritic cells
• Ethyl pyruvate
• HMGB1
• Metformin
• Transplantation

Statement dc:rights

• IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

eng

Dc Identifier Other

965641441

OAI identifier oai:identifier

oai:scholarshare.temple.edu:20.500.12613/934