Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1280 for “"Immunology"”.
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Malaria immunology and vaccine development
This thesis describes work undertaken by the author at the University of Oxford. It<br/>begins by providing an introduction to malaria infection and pathophysiology, and<br/>a review of the latest attempts to produce an effective malaria vaccine. It goes on<br/>to describe the rationale behind the …
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Studies on immunology of Leishmania mexicana
Leishmaniasis is a worldwide disease prevalent in many tropical and sub tropical countries. Treatment of Leishmaniasis by chemotherapy is not wholly effective and is usually accompanied by unpleasant side effects. The development of an effective and inexpensive vaccine represents a practical way to …
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Machine Learning Methods for Cancer Immunology
… immune system is a fundamental goal of cancer immunology. The first part of this thesis describes a three-stage association study to address this challenge in pancreatic ductal adenocarcinoma (PDAC). Firstly, network-based approaches are used to characterise PDAC on the basis of transcription …
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Systems Immunology Approaches for Precision Medicine
… three studies highlighting phases of a systems immunology cycle. Firstly, the thesis provides a description of the construction of a computational ordinary differential equation based model on the host-pathogen-microbiota interactions during Clostridium difficile infection and the use of this …
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Immunology based methodology for detecting and searching anomalies
"Anomaly detection can be defined as the identification of any abnormalities occurring in the normal functioning of a system. A related problem is search for the occurrence of a specific event from a set of large type of possible events. A brute force search or detection of anomalies is …
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The Immunology of Adeno-Associated Virus Serotype 2
Adeno-associated virus serotype 2 (AAV-2) has been developed as a gene therapy vector. Antibody and cell-mediated immune responses to AAV-2 or AAV-2 transfected cells may confound the therapeutic use of such vectors in the clinic. In this study, cell-mediated and humoral immune responses to AAV-2 …
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Mathematical Modelling of Immuno-Oncology and Related Immunology
… results from lingering unanswered questions in immunology and partly results from the inevitable variability between one patient and the next. Here we look specifically at Chimeric Antigen Receptor (CAR)-T cell therapy, explore the mechanisms by which this living drug grows and changes inside …
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Dimensionality reduction in immunology : from viruses to cells
Developing successful prophylactic and therapeutic strategies against infections of RNA viruses like HIV requires a combined understanding of the evolutionary constraints of the virus, as well as of the immunologic determinants associated with effective viremic control. Recent technologies enable …
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Investigations into the immunology, physiology and epidemiology of pertussis
This volume contains an introduction to the topic of pertussis followed by twelve papers on pertussis arising from research conducted while I was a research fellow at St. George's Hospital Medical School from 1985 to 1988. Paper 1 provides a qualitative description of the serum antibody responses …
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Immunology and virology of HIV-1 infection in Cameroon
This study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M …
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Mathematical Models of Underlying Dynamics in Acute and Chronic Immunology
During an immune response, it is understood that there are key differences between the cells and cytokines that are present in a primary response versus those present in subsequent responses. Specifically, after a primary response, memory cells are present and drive the clearance of antigen in …
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Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology
The mucosal immunity of the gastrointestinal (GI) tract is constituted by a complex, highly specialized and dynamic system of immune components that aim to protect the gut from external threats. The sustained exposure of the mucosal immune system of the GI tract to an enormous number of lumen …
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Investigating Modular Structure and Function in Biology: from Immunology to Cognition
Modularity is the grouping of the components of a complex system into distinct units. Modular structure is pervasive in biology and has been especially studied in biological networks, including metabolic circuits, protein-protein interaction networks, ecological food webs, and human brain networks. …
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Babesia Bovis: Detection and Characterization of Culture-Derived Exoantigens (Immunology, Parasitology)
A two-site enzyme-immunoassay was developed to detect culture-derived Babesia bovis exoantigens. Bovine anti-B. bovis IgG was used as a capture antibody and as a recognizing antibody. A capture antibody concentration of 10 ug/ml and test samples at protein concentrations of 100 ug/ml gave optimal …
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Studies on the Biology and Immunology of Ascaris Suum in Mice
Made available in DSpace on 2014-12-10T18:13:34Z (GMT). No. of bitstreams: 1 6808147.pdf: 10154033 bytes, checksum: e0c17cfd48a251ccdeab2613784916b3 (MD5) Previous issue date: 1967
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The development of fluorescence lifetime imaging and an application in immunology
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:35:59Z Item is restricted indefinitely.
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Combatting pathogens through directed evolution, single-cell sequencing, and synthetic immunology
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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