Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Memory T cells"”.
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In vitro generation and programming of human CD8+ memory T cells
… the generation of persistent and functional memory CD8+ T cells. The integration of a multitude of signals during naïve cell activation plays an important role in the programming of CD8+ T cells responses. However, knowledge of the regulation of naïve cell programming in humans is limited. …
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The Role of Gammadelta T Cells and CD8+ Memory T Cells in Vaccinia Viral Infection
… a complex process by diverse populations of cells, that can be harnessed for tumor immunotherapies and vaccinations. Vaccinia virus (VV) is the most studied member of the poxvirus family and is responsible for the successful elimination of smallpox worldwide. It is unique among well-studied …
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Differential regulation and functions of the ZFP36-family RNA binding proteins in CD8⁺ memory T cells
CD8⁺ T cells target infected or malignant cells via cytotoxicity and the production of pro inflammatory cytokines and chemokines. In addition to antigen-specific responses mediated by the TCR, pro-inflammatory cytokines such as IL-12 and IL-18 can induce antigen-independent bystander activation of …
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The Role of CCR7 and Its Ligands in a Behcet’s Disease Mouse Model
… of CCR7 ligand DNA induces the expression of memory T cells. It was also reported that expression of CCL21 in Behcet’s Disease (BD) patients was low. In this study, we investigated the expression of CCR7 and its ligands in BD mice, and also observed the changes of memory T cells and BD …
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A novel model system for the study of anti-tumour T-cell memory
… the fate and requirements of longterm persisting memory T-cells can be monitored. Anti-tumour immune peritoneal exudate cells (iPEC) were produced by injecting a subtumorigenic dose of the highly metastatic, ß-gal<sup>+</sup> T-Iymphoma into the ear pinna of syngeneic DBN2 mice, followed by an …
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Towards unravelling the immunomodulatory mechanisms of S. mansoni & L. major parasites in a mouse model using transgenesis
… that an understanding of the ability of memory T cells to withstand pathogen manipulation is crucial for the development of effective vaccine strategies to control these pathogens. Therefore, in this study, OVA transgenic S. mansoni and OVA transgenic L. major were generated to use as a …
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Mathematical Models of Underlying Dynamics in Acute and Chronic Immunology
… that there are key differences between the cells and cytokines that are present in a primary response versus those present in subsequent responses. Specifically, after a primary response, memory cells are present and drive the clearance of antigen in these later immune responses. When …
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Anti-inflammatory Role of IL-15Rα Up-regulated by Poly I:C in Herpes Simplex Virus-induced Behcet's Disease-like Mouse Model
… monocytes and mediates the proliferation of memory CD8+ T cells. Recent studies informed that Polyinosinic:polycytidylic acid (Poly I:C) is an immunostimulant which boosts the generation of memory T cells though induction of IL-15 and IL-15Rα. We found that the frequencies of IL-15Rα were …
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Assessing the Efficacy of Interleukin-7 as an Immunotherapeutic in the SIV+ Rhesus Macaque Model
… infection is known for depleting ‘helper’ CD4+ T cells. Highly active antiretroviral therapy (HAART) reduces viremia and increases CD4+ levels, however, 5-20% of patients fail to reconstitute CD4+ T cell levels despite viral suppression. Interluekin-7 (IL-7), a homeostatic cytokine, increases …
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CD8⁺ T Cell Response to Influenza Virus
… system. The cell-mediated lysis of infected cells is a particularly important step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to the lungs, where they selectively …
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Novel protocols to induce tolerance to solid organ transplants
Dendritic cells (DCs) are the sentinels of the immune system. They mature at the encounter of the appropriate stimuli or danger signals, which induce them to perform pro-inflammatory antigen presentation to naïve and memory T cells, resulting in inflammation. Remaining in an immature state however, …
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NOVEL RNA-BASED CANCER VACCINE FOR AML IMMUNOTHERAPY
… in leukemic burden in both the liver and lung. Memory T cells play a key role in this. Combination therapy with anti-programmed death-ligand 1 has provided the AML mice with significant survival benefits. These data provide preclinical evidence for human study in the future.
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Using single-cell RNA sequencing to elucidate the biological basis of IBD and response to therapy
… project utilised peripheral blood mononuclear cells (PBMCs) to investigate the effects of IBD-associated genetic variants in an ex vivo setting, while the second project utilised a co-culture model to understand the immune-cell response to anti-TNF therapy. In the first research chapter of this …
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Defining mRNA-generated T cell memory in respiratory viral infection
T cell immune memory provides protective effector mechanisms to restrict pathogen growth upon secondary infection, although the ability of T cells generated by novel mRNA-LNP vaccines to restrict viral infection in currently unknown. To address this, we studied antigen specific T cell memory …
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Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis
… tuberculosis (Mtb). Even though CD4 T cells are critical for containing Mtb, the immune system rarely eradicates the bacteria, necessitating the maintaining of an antigen-specific CD4 T cell response throughout the course of infection. How this response is maintained is not currently …
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Characterisation of Mycobacterium tuberculosis specific T cell immunity with HLA class II tetramers
… against TB is thought to depend on specific T cells. However, exactly which T cell characteristics are required for immunological protection is unknown. To gain a better understanding of M. tuberculosis (M.tb)-specific memory T cell immunity, we studied longevity and function of M.tb-specific …
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Coordinated Blockade of TGF-β and PD-L1 Promotes Anti-Tumor Immunity in Ovarian Cancer Models
… anti-tumor immune skewing of macrophages, NK cells, and T effector memory cells, corresponding with long-term immunological memory responses. BA treatments enhanced cytotoxicity that was traced back to resident memory T cells and decreased suppressive Gata6+ large peritoneal macrophages in the …
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Multigenic Regulation of the Shutdown of Immune Responses
… generating increased numbers of antigen-specific memory CD8+ T cells. During acute viral infection, large numbers of effector CD8+ T cells are generated. Following viral clearance, the majority of these cells undergo apoptosis during the contraction phase, while the surviving cells differentiate …
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Hypoxia Acts As An Environmental Cue For The Human Tissue-Resident Memory T-Cell Differentiation Program
<p>Tissue-resident memory T-cells (T<sub>RM</sub>) provide frontline defense against viral diseases and can contribute to anti-tumor immunity; however, aside from the necessity of TGF-β, little is known regarding cues for T<sub>RM</sub> differentiation. Oxygen tension is an environmental cue that …
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Characterization of viral- and fungal-reactive CD4+ T cells in healthy and diseased
… the expansion of high-avidity spike-specific T cells derived from the naïve repertoire, whereas increased pre-existing memory T cells and aging can impair T cell expansion and reduce vaccine responsiveness. The second study identifies commensal and food-derived yeasts as important drivers of …
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