Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 121 for “"Metformin"”.
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Mechanism of Metformin Action in Dermal Fibroblasts
… insulin therapy include biguanide drugs such as metformin. Metformin downregulates gluconeogenesis, and reduces blood glucose levels by activating glucose transport via GLUT4 in muscle cells. Importantly metformin has been shown to decrease mitochondrial respiratory complex I activity in …
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Metformin as a potential therapy for malignant astrocytoma
… medication as a possible alternative option. Metformin is from the biguanide family of drugs and is the most common medication used in the treatment of type 2 diabetes. Clinical studies have reported that, in type 2 diabetic patients, metformin might reduce cancer incidence and severity. …
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The effects of metformin on the vascular system
… contraction and relaxation effects of metformin were measured using a Mulvany Halpern myograph. Mouse aortic ring sections were treated for 1 and 4 hours in vitro with metformin at 10-5M, and for 2, 4 and 8 weeks in vivo with metformin at 250mg/kg/day. The rings were contacted with …
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The effects of metformin on the gastrointestinal tract
Metformin is the world’s most prescribed drug and is recommended first-line therapy for the treatment of Type 2 Diabetes Mellitus (T2DM). Numerous clinical studies have demonstrated that metformin is an effective oral agent in normalising blood glucose levels. Metformin is also one of the very few …
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Therapeutic Management of Burn Induced Hyperglycemia with Insulin and Metformin
… for alternative glucose modulating agents. Metformin, a well-known anti-hyperglycemic agent, has been shown to decrease burn induced hyperglycemia in adults. Relative euglycemia was attained by use of metformin exclusive of the adverse effects associated with insulin administration …
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Uso do metformin em mulheres obesas com a síndrome dos ovários policísticos
Resumo não disponível.
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Direct Effects of Metformin On Pi3K and Ras Signaling In Endometrial Cancer
<p>Metformin has antiproliferative effects through the activation of AMPK and has gained interest as an antineoplastic agent in several cancer types, although studies in endometrial cancer (EC) are limited. The aims of this project were to evaluate pathways targeted by metformin in EC, investigate …
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Removal of Metformin and Clarithromycin from aqueous media using Magnetic Brewery Spent Grain
… for two prioritised pharmaceuticals, metformin (MF) and clarithromycin (CLR). Response surface methodology (RSM) was applied to identify optimal adsorption parameters for the most promising material, magnetic brewery spent-grain biochar (MBSG). Under these optimal conditions removal …
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The Role of Amino Acid Transport in the Regulation of mTORC1 by Metformin
The antihyperglycaemic drug metformin has become the most widely prescribed drug treatment for the management of type 2 diabetes mellitus. Despite being prescribed for over 50 years, the precise molecular mechanisms underlying metformin’s therapeutic effects remain poorly understood. Newly …
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The independent and combined effects of rapamycin and metformin on naturally occurring osteoarthritis
… or diets enriched with rapamycin (Rap; 14ppm), metformin (Met; 1000ppm), or a combination of rapamycin plus metformin (Rap+Met) for 3 months. Hind limbs were collected for histopathological and radiographic evaluation of the knee joint. Histological OA scores in DH guinea pigs receiving Rap and …
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Investigation of the metabolic phenotype and metformin response of <i>ATM</i> heterozygous mice
Metformin, as an anti-hyperglycaemic drug, is commonly prescribed for type 2 diabetes (T2D) treatment. However, 35% of patients experience adverse reactions to metformin and some patients that tolerate metformin do not respond with glucose lowering. The identification of biomarkers that inform of …
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Fate and behaviour of metformin and its transformation product guanylurea in soil-water systems
Due to the widespread occurrence of diabetes, metformin (MET) has become one of the most prescribed medicines in the world. The human body excretes MET through urine and faeces as an unchanged compound and MET eventually ends up in wastewater treatment plants, where the compound is transformed into …
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METFORMIN, CLIC1 AND TRANSCRANIAL STIMULATION: THE BASIS OF A NEW TARGETED THERAPY AGAINST GLIOBLASTOMA RELAPSE
… Recently, tmCLIC1 has been proposed to be one of metformin’s targets. In this work, we show molecular and functional evidence of the direct metformin-CLIC1 interaction, by NMR, MicroScale Thermophoresis, and single-channel patch-clamp experiments. However, due to the blood brain barrier, the high …
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Analysis Of The Effects Of Metformin Administered Alone Or In Combined Treatments In Colorectal Cancer
… anticancer activity of the anti-diabetic drug metformin, individually or combined in various settings with chemotherapy, on in vitro models of colorectal cancer (CRC). I found that metformin reduced cell proliferation by inducing cell cycle arrest in the G0/G1 phase, but did not lead to cell …
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Cardiovascular Effects of Metformin on Left Ventricular Hypertrophy in Nondiabetic Patients with Coronary Artery Disease
… are implicated in the development of LVH. Metformin - an anti-diabetic drug, has been shown to reduce body weight and to improve insulin sensitivity, thus reducing IR. These properties of metformin may have the potential of regressing LVH. Additionally, metformin has complex multiple modes …
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Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery
Metformin, an anti-diabetic drug, has a low oral bioavailability (50-60%) due to its poor intestinal absorption. Orally administered mucoadhesive nanoparticles have been shown to interact with the intestinal mucus layer and increase the intestinal permeability of the entrapped drug. The objective …
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The effect of maternal obesity/GDM and metformin intervention on maternal, placental and fetal health
… by excessive glucose exposure. In many countries metformin (an oral glucose-lowering agent) is now the first line pharmacological treatment for GDM as it can control maternal glycaemia and reduce gestational weight gain. However, metformin can cross the placenta and thereby directly affect the …
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