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Showing 1 to 20 of 42 for “"HMGB1"”.
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Investigation of the proteins SPARC and HMGB1 in chronic airways disease
… role of extracellular high mobility group box 1 (HMGB1) in AECs. HMGB1 is a danger-associated molecular pattern (DAMP) that normally resides in the intracellular compartment, and is released into the extracellular space upon cellular injury, stress or death to orchestrate inflammatory responses. …
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HMGB1- An Immunotherapeutic Target for the Treatment of Neonatal Sepsis and Associated Neuroinflammation
… generated against the late inflammatory mediator HMGB1 using proprietary adjuvant CoVaccine HTTM. It was found that these antibodies had potent binding affinity and neutralising capacity in vivo and in vitro. Administration of these antibodies during murine neonatal sepsis conferred significant …
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Investigation into the role of HMGb1 in relation to myofibroblasts and cancer cells exposed to various conditions
… be involved in all stages of tumour progression. HMGb1 is a nuclear protein that plays an important role in nucleosome stabilisation and gene transcription. Whilst HMGb1 is a nuclear protein, it has been reported to takes part in the immune system when passively released by necrotic cells or …
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Multidrug resistance proteins (MRP) transport the cytokine/nuclear protein High Mobility Group Box 1 (HMGB1) across membranes
High mobility group box 1 (HMGB1) is a mobile chromatin protein that can relocate into the external environment and act as a cytokine. HMGB1 cellular release can be passive, by cell necrosis, or active, by living cells after a specific stimulus is received. HMGB1 does not possess a leader sequence, …
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LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS TO HMGB1 AND ITS REGULATED SECRETION IN LUNG CANCER
High mobility group box 1 (HMGB1) is a chromatin-associated protein that is also secreted from activated immune cells, necrotic cells, and certain cancer cells. Previous studies have described that different patterns of post-translational modification (PTM), particularly acetylation and oxidation, …
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The Eosinophil Granular Leukocyte; Source and Target of High Mobility Group Protein B1
… symptoms. The high mobility group protein B1 (HMGB1) was discovered in the nuclear fraction of non-activated peripheral blood eosinophils through a proteomic profiling project. The protein was identified by MALDI-TOF/TOF and its presence was confirmed by Western blot analysis. Given recent …
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Pathological mechanisms of the ischemic white matter injury in animal model of lacunar infarction
… protein family or high mobility group box 1 (HMGB1).have been identified. I found substantial accumulation of HMGB1, but not members of heat shock protein family, in OL-bathing media after OGD. OLs expressed HMGB1 in nucleus in vitro and in vivoin uninjured condition. After OGD, HMGB1 in OLs …
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Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis
… Zytokins High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) nachgewiesen. In Zellkulturexperimenten wurde die Auswirkung von entzündlichem Zellstress auf die Expression der beiden Moleküle und auf Zelltod hin ermittelt. Zusätzlich wurden …
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Identifying Key Regulators of the Immune/Inflammatory Response for Developing Anticonvulsive and Antiepileptogenic Approaches
… type 1 (IL-1R1) and High Mobility Group Box 1 (HMGB1)/Toll-like Receptor 4 (TLR4) axes are key initiators of neuroinflammation following epileptogenic injuries. Experimental and clinical evidence showed that endogenous anti-inflammatory mechanisms are not efficiently activated in epileptogenic …
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Understanding the functions of HMGB proteins in the mechanism of action of cisplatin
… damage will be introduced with a focus on HMGB1, the most vigorously investigated HMGB protein. Additionally, other HMGB 1-mediated processes that may be related to cisplatin-triggered cell death will be discussed. Lastly, the correlation between testis-specific HMGB proteins and the …
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PURIFICATION AND INTERACTION STUDIES OF HISTONE, HMGB, AND PPI PROTEINS, FACILITATED BY THE DIPOLAR NATURE OF HMGBS
… on their dipolar nature. At high concentration, HMGB1 proteins were used to pull out a potential HMGB1/FKBP3 complex from a pool of nuclear proteins. Technology to significantly enhance the concentration of HMGB1 in chicken plasma was also developed, as the basis for prompt, low cost measurement …
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Integrated imaging and circulating biomarkers for the assessment of drug-induced hepatotoxicity
… (ALT) and High mobility group box 1 (HMGB1) is an informative and early serum indicator of cell death and inflammatory processes in Paracetamol (APAP)-induced liver injury (APAP-ILI). The mechanistic nature of these biomarkers allows for a deeper understanding of the basis to the …
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DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS
… the DNA-binding domain of the oncogenic protein HMGB1. Third, aptamers were designed to bind the CD4-binding site of the HIV-1 envelope glycoprotein GP120, thereby blocking viral entry. All projects followed a multi-step computational and experimental pipeline. Protein structures retrieved from …
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NMR Studies on Kinetics of Processes Involving DNA-Binding Proteins
… the redox state of DNA binding proteins such as HMGB1 could play an important role in its function. The reduction/oxidation kinetics of HMGB1 along with redox regulatory proteins are extensively analyzed in Chapter V using NMR based methods. This thesis provides an understanding into the …
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Dynamik und Funktion der HMG-Proteine
… dass HMGN1, HMGN2, HMGA1a, HMGA1b und HMGB1 sich sehr schnell durch den Zellkern bewegen und nur transient an das Chromatin gebunden sind. Es konnte gezeigt werden, dass die spezifischen DNA/Chromatin-Bindungsmotive im Wesentlichen entscheiden, wo die Bindung der HMG-Proteine in vivo …
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Protective effects of regular exercise and Korea red ginseng against high-fat diet-increased renal injury in ᴅ-galactose-induced aging rats
… extracellular high mobility group box 1 protein (HMGB1), a signal of tissue damage) and receptor for AGE (RAGE) were extensively expressed in renal tissues of the GAL/HFD group than that in the GAL group. HMGB1 was clearly translocated from the nucleus to the cytoplasm in renal tubular epithelial …
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NMR Studies on Protein Dynamics and Its Relevance to Functional Kinetics.
… this method we determined oxidation speed of HMGB1 protein in human blood serum and saliva, as well as in extracellular fluids. Different effect of these fluids on HMGB1's oxidation clearly showed the importance of in situ experiments for better understanding of protein function in its natural …
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Cellular responses against DNA damaged by platinum anticancer drugs
… protein (TBP) and high mobility group protein HMGB1, both highly abundant and vital proteins, are reported to bind cisplatin- damaged DNA and to be involved in mediating the cytotoxic activity of platinum-based agents. Chapters 2 and 3 discuss the structural and kinetic properties of both …
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Mechanism-based rational design of cisplatin analogues
… evaluated for their ability to upregulate HMGB1 and screened for cytotoxicity against human breast cancer cell lines. All BEPn complexes induced the overexpression of HMGB I in ER(+) MCF-7 cells. BEP3 was nearly twice as cytotoxic in ER(+) MC'F-7 cells than in ER(-) HCC-1937 cells. This …
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Altérations fonctionnelles des cellules dendritiques dans la cancérisation du col utérin
… leurs interactions. Nous avons identifié HMGB1 comme étant la molécule impliquée dans la modification du phénotype et de la fonction des pDC exposées au microenvironnement du col utérin. En parallèle, nous avons démontré que les cDC différenciées en présence de lignées de SCC du col utérin …
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