Translational Regulation of the C-Jun Proto-Oncogene

<p>The <em>v-jun</em> oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation. The c-Jun protein is a transcription factor which binds to the DNA target TGACTCA. The c-Jun protein binds to DNA in the form of dimers. It can form homodimers with itself and heterodimers with Jun family (JunB and JunD), Fos family (FosB, Fra1 and Fra2), or with CREB family members through the leucine zipper motif. Because the <em>c-jun</em> proto-oncogene plays an important role in cell transformation, extensive work has been done to understand how it is regulated. Previously, it has been shown that c-jun transcription can be activated by growth factors, tumor promoters and other oncogenes such as <em>ras</em> and <em>src</em>. Regulation of <em>c-jun</em> activity has been studied at the level of transcription, dimerization, DNA binding and post-translational modification. I report here that the <em>c-jun</em> proto-oncogene can also be regulated at the translational level.</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biological Sciences

Year dc:date.available

1994

Author dc:creator

• Sehgal, Anil

Contributors dc:contributor

• Timothy J. Bos
• Richard Stenberg
• William Wasilenko
• Frank Castora
• Mark S. Elliot

• Oncogenes
• Proto-oncogenes
• Cell transformation
• Cell Biology
• Microbiology
• Molecular Biology

Repository record dc:identifier

https://digitalcommons.odu.edu/biomedicalsciences_etds/130

OAI identifier oai:identifier

oai:digitalcommons.odu.edu:biomedicalsciences_etds-1134