Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Proto-oncogenes"”.
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Spatial organisation of proto-oncogenes in human haematopoietic progenitor cells
… regions that spatially co-associate with the proto-oncogenes MLL, ABL1 and BCR. In addition to further developing the laboratory protocol, I have created bioinformatics tools used in the analysis of the sequencing data. I find that the association profiles of the three genes show strong …
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Regulation of proto-oncogenes and immune system genes during CSF-1-induced macrophage differentiation
… treatment of BMDM enhanced the expression of all proto-oncogenes, however the c-myc mRNA levels were highest on day 3 of culture. IFN-$\gamma$ treatment of BMDM cultures also enhanced the transcription of proto-oncogenes. Thus, it is felt that c-fms, c-fos and c-myc may be related to the complex …
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The Tumor Suppressor Notch Inhibits Head and Neck Squamous Cell Carcinoma (Hnscc) Tumor Growth and Progression By Modulating Proto-Oncogenes Axl and Ctnnal1 (Α-Catulin)
… analysis and observed suppression of two proto-oncogenes, AXL and CTNNAL1 (α-catulin)<em> </em>after NOTCH1 activation, but not in its absence. In addition, genes modulated by NOTCH activation in cell lines correlated with RNA-Seq data from 498 TCGA patient tumors. Restoration of NOTCH1 in …
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
… interactions, including binding to proto-oncogenes and tumor suppressors to regulate cell death. Here we show that the IP3R binds to the tumor suppressor BRCA1. BRCA1 binds directly to the IP3R and causes destabilization of the IP3R closed state resulting in an increased open …
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Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy
… understanding of tumor onset. Several important proto-oncogenes and proteins involved in angiogenesis have been identified, leading to the development and clinical use of several new anticancer agents. We succeeded in preparing microbubbles which are able to carry genetic (pDNA, siRNA) and …
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Changes in macrophage functions and gene expression during tumor growth
… in TBH Mφ cell-cycle kinetics and maturation, proto-oncogene expression was examined in normal host and TBH Mφ. The proto-oncogenes c-myb, c-myc, c-fos, and c-fms are constitutively expressed in TBH Mφ, while normal host M@ express c-fos and c-fms but at lower levels. Adherence suppresses the …
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Effects of Long-Term Exposure of Normal C57BL/6J Inbred Mice to 17β-Estradiol on Gene Expression in Lymphocytes: mRNA Analysis of Lymphokines and bcl-2/fas
… to 17β-estradiol on lymphokine and bcl-2/fas (proto-oncogenes) mRNA expression. We evaluated the effects of estrogen on the expression of genes for lymphokines, which are essential for the immune response. It is hypothesized that estrogen may regulate the immune system by modifying the …
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Androgen Regulation of Gene Expression Associated with Cell Growth and Neural Plasticity: Studies in Songbird Brain and the S115 Cell Line
… I cloned the canary homolog of the c-jun proto-oncogene, and confirmed its identity based on complete conservation of the important functional domains. I prepared RNA from steroid responsive parts of the brain from ovariectomized canaries treated with testosterone using a simple dot …
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The Role of Protein Phosphatases in Regulation of Drosophila S6 Kinase by Nutrient Signaling Pathways
… components of nutrient signaling pathways are proto-oncogenes, of equal importance is identifying and characterizing the components utilized to down-regulate growth, as mutations in these genes may also lead to genesis of disease. Protein phosphatase 2A (PP2A) is a major intracellular protein …
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Targeting Myc-driven tumours - BETing on ATR
… suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell proliferation. Oncogenic transformation of multifaceted proto-oncogene - transcription factor - MYC can give rise to cancers and …
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Proto-oncogene Regulation by Growth Factors in Bone Cells
… the molecular level, the expression of several proto-oncogenes was studied. IGF-I and IGF-II cause a rapid and transient induction of c-fos in MC3T3-E1 cells similar to that observed with other growth factors in other cell types. TGF-beta causes a similar rapid induction of c-fos which is …
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blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
… been shown to be orthologous to Ras-cooperating proto-oncogenes and tumor-suppressor genes, respectively. Because several epigenetic regulators are now targets of cancer treatments and many cancer genomes exhibit changes in epigenetic regulation, I sought to systematically identify chromatin …
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Evaluation of Altered Kras Codon Bias and NOS Inhibition During Lung Tumorigenesis
… protein sequences, the three <italic>RAS proto-oncogenes exhibit divergent codon usage. Of the three isoforms, <italic>KRAS contains the most rare codons resulting in lower levels of KRAS protein expression relative to <italic>HRAS and <italic>NRAS. To determine the consequences of rare …
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Elucidating the constitutional genetic basis of multiple primary tumours
… variation affecting tumour suppressor genes or proto-oncogenes and recent improvements in sequencing technology have led to greater capability to detect more affected individuals through diagnostic testing. Predisposition syndromes can be suggested by a variety of clinical indicators that can be …
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A promoter characterisation of the Ets transcription factor gene, Ese-2/Elf-5
… of around 30 members. They have been shown to be proto-oncogenes and it is this feature that has elicited much research into their regulation and function in both normal and neoplasic tissue. The high level of conservation within the ETS domain of the family identifies all Ets proteins as …
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Elucidating the Principles of Brain Network Organisation through Neurosurgery
… oligodendrocyte precursor cells (OPCs), and proto-oncogenes are uniquely enriched in the MD system making it vulnerable to oncogenesis. When investigating the cognitive impact of gliomas infiltrating the MD system, the data reveals long-term cognitive improvements, indicating the brain …
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Translational Regulation of the C-Jun Proto-Oncogene
… leucine zipper motif. Because the <em>c-jun</em> proto-oncogene plays an important role in cell transformation, extensive work has been done to understand how it is regulated. Previously, it has been shown that c-jun transcription can be activated by growth factors, tumor promoters and other …