Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 176 for “"Oncogenes"”.
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Spatial organisation of proto-oncogenes in human haematopoietic progenitor cells
… that spatially co-associate with the proto-oncogenes MLL, ABL1 and BCR. In addition to further developing the laboratory protocol, I have created bioinformatics tools used in the analysis of the sequencing data. I find that the association profiles of the three genes show strong correlation …
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Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
… study, gene expression signatures of six GFRN oncogenes overexpressed in human mammary epithelial cells (HMECs) were generated to interrogate this pathway’s downstream crosstalk, beyond initial mutation status. Utilization of this method may reveal novel phenotypic patterns that could be used …
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Molecular and functional studies of ABL1 and FGFR1 fusion oncogenes in myeloproliferative neoplasms
… thesis was to study BCR/ABL1 and FGFR1 fusion oncogenes in a relevant cellular context, that of primary human hematopoietic cells, in order to increase our understanding of disease mechanisms underlying the development of CML and EMS. In Article I, a secondary translocation between chromosomes …
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The mechanism of HAMLET-induced cell death - cellular signalling, oncogenes and clinical perspectives
Despite recent advances in cancer treatment, truly innovative approaches are required to move beyond the modest benefits achieved to date. HAMLET is a human protein-lipid complex originally discovered in breast milk able to kill a wide range of tumour cells while leaving healthy, differentiated …
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Hormonal modulation of sex steroid hormone receptors and oncogenes in human breast cancer cells
Since sex steroids modulate breast tumor growth, and high levels of the HER-2/neu protooncogene protein may contribute to breast cancer metastasis, the effects of estrogen, progestin and hormone antagonists on the levels of estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu mRNA and …
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Regulation of proto-oncogenes and immune system genes during CSF-1-induced macrophage differentiation
… of BMDM enhanced the expression of all proto-oncogenes, however the c-myc mRNA levels were highest on day 3 of culture. IFN-$\gamma$ treatment of BMDM cultures also enhanced the transcription of proto-oncogenes. Thus, it is felt that c-fms, c-fos and c-myc may be related to the complex …
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Of Apoptosomes and Oncogenes: Repurposing a Death Machine & Deconstructing the Action of P53 Mutations
It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. I show here that Tango7 genetically …
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P53-dependent apoptosis modulates the cellular response to oncogenes and the cytotoxicity of anticancer agents
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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Nucleic acid clamp-mediated transcriptional and translational modulation of oncogenes via the stabilization of G-quadruplexes
G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures that exit in various biologically important regions within a cell, such as the promoters of DNA, 5’-Untranslated regions (UTR) of mRNA and telomeres. These secondary structures tend to cluster around 1 kb from transcriptional …
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THE EFFECTS OF RETINOIC ACID ON CELLULAR TRANSFORMATION AND TUMORIGENESIS INVOLVING CELLS WITH KNOWN ONCOGENES (VITAMIN A, RETINOIDS, RETROVIRUS)
Vitamin A is known to have an important role in cellular differentiation and proliferation. In addition to regulating normal cellular processes vitamin A has also been shown to possess potent antineoplastic activity. The work in this dissertation characterizes the role of retinoic acid (RA) in …
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The Tumor Suppressor Notch Inhibits Head and Neck Squamous Cell Carcinoma (Hnscc) Tumor Growth and Progression By Modulating Proto-Oncogenes Axl and Ctnnal1 (Α-Catulin)
… analysis and observed suppression of two proto-oncogenes, AXL and CTNNAL1 (α-catulin)<em> </em>after NOTCH1 activation, but not in its absence. In addition, genes modulated by NOTCH activation in cell lines correlated with RNA-Seq data from 498 TCGA patient tumors. Restoration of NOTCH1 in …
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A mouse model to study inducible oncogene cooperation <i>in vivo</i>
… multiple changes occur in two kinds of genes: oncogenes and tumour suppressor genes.<br></br><br></br> Oncogene-products can be classified as growth factors, growth factor receptors, Ras oncoproteins, cytoplasmic protein kinases, transcription factors, anti-apoptotic proteins.<br></br><br></br> …
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Tobacco carcinogen induced mouse lung adenocarcinoma cell lines as tools to identify novel lung cancer genes
… the last decades many new lung adenocarcinoma oncogenes have been identified and thus new anticancer agents have been introduced in the clinical practice. These agents have changed the prognosis and the quality of life of patients. However, due to limitations the underlying driver oncogenes …
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Oncogene-Induced Signaling Heterogeneity in Lung Cancer
… has identified 138 frequently occurring driver oncogenes and tumor suppressor genes in lung cancer. Currently, only 15 of these genes can be targeted therapeutically. Study of downstream signaling alterations of these oncogenes and tumor suppressor genes may identify novel therapeutic targets. …
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Tissue-specific interactions between oncogenic K-ras and the p19A̳r̳f̳_p53 pathway determine susceptibility to transformation
… action of gain-of-function mutations in oncogenes and loss-of-function alterations in tumor suppressor genes. The particular spectrum of mutations in a given cancer is rarely the result of random chance but instead derives from the intimate connections between proliferative networks and …
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Gene mutations and expression in breast cancer
… is a multigenic disorder with mutations in oncogenes and tumour suppressor genes playing an important role in cellular transformation and ultimately in tumour formation. In this study, 40 breast cancer patients from the Western Cape province in South Africa and 4 breast cancer cell lines …
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Expressão de HER-2/neu e p53 em adenocarcinoma de esôfago e cárdia
… da biologia molecular e descoberta de oncogenes e genes supressores de tumores permitiu novos achados e melhor entendimento das características moleculares dos carcinomas de esôfago e cárdia. Novos genes envolvidos em ciclo celular, apoptose e reparo de DNA são agora alvo importante de …
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Mechanisms of human papillomavirus and host gene transcriptional deregulation in cervical carcinogenesis
… caused by the deregulated expression of HPV16 oncogenes E6 and E7 in proliferating basal cells of the cervical squamous epithelium. The major risk factor associated with cervical neoplastic progression is integration of HRHPV into the host genome, which is detected in $~$85% of HPV16-positive …
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