The v-jun oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation. The c-Jun protein is a transcription factor which binds to the DNA target TGACTCA. The c-Jun protein binds to DNA in the form of dimers. It can form homodimers with itself and heterodimers with Jun family (JunB and JunD), Fos family (FosB, Fra1 and Fra2), or with CREB family members through the leucine zipper motif. Because the c-jun proto-oncogene plays an important role in cell transformation, extensive work has been done to understand how it is regulated. Previously, it has been shown that c-jun transcription can be activated by growth factors, tumor promoters and other oncogenes such as ras and src. Regulation of c-jun activity has been studied at the level of transcription, dimerization, DNA binding and post-translational modification. I report here that the c-jun proto-oncogene can also be regulated at the translational level.
","abstract_html":"<p>The <em>v-jun</em> oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation. The c-Jun protein is a transcription factor which binds to the DNA target TGACTCA. The c-Jun protein binds to DNA in the form of dimers. It can form homodimers with itself and heterodimers with Jun family (JunB and JunD), Fos family (FosB, Fra1 and Fra2), or with CREB family members through the leucine zipper motif. Because the <em>c-jun</em> proto-oncogene plays an important role in cell transformation, extensive work has been done to understand how it is regulated. Previously, it has been shown that c-jun transcription can be activated by growth factors, tumor promoters and other oncogenes such as <em>ras</em> and <em>src</em>. Regulation of <em>c-jun</em> activity has been studied at the level of transcription, dimerization, DNA binding and post-translational modification. I report here that the <em>c-jun</em> proto-oncogene can also be regulated at the translational level.</p>","abstract_has_math":false,"creators":["Sehgal, Anil"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Biological Sciences","degree_department":null,"school":null,"contributors":["Timothy J. Bos","Richard Stenberg","William Wasilenko","Frank Castora","Mark S. Elliot"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1994,"date_issued":"1994-04-01T08:00:00Z","date_published":"1994-04-01T08:00:00Z","updated_at":"2026-07-24T03:35:23Z","subjects":["Oncogenes","Proto-oncogenes","Cell transformation","Cell Biology","Microbiology","Molecular Biology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.odu.edu/biomedicalsciences_etds/130","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Timothy J. Bos","Richard Stenberg","William Wasilenko","Frank Castora","Mark S. Elliot"]},{"key":"dc:creator","label":"Author","values":["Sehgal, Anil"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2019-10-16T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biological Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Oncogenes","Proto-oncogenes","Cell transformation","Cell Biology","Microbiology","Molecular Biology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.odu.edu/biomedicalsciences_etds/130"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The v-jun oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation. The c-Jun protein is a transcription factor which binds to the DNA target TGACTCA. The c-Jun protein binds to DNA in the form of dimers. It can form homodimers with itself and heterodimers with Jun family (JunB and JunD), Fos family (FosB, Fra1 and Fra2), or with CREB family members through the leucine zipper motif. Because the c-jun proto-oncogene plays an important role in cell transformation, extensive work has been done to understand how it is regulated. Previously, it has been shown that c-jun transcription can be activated by growth factors, tumor promoters and other oncogenes such as ras and src. Regulation of c-jun activity has been studied at the level of transcription, dimerization, DNA binding and post-translational modification. I report here that the c-jun proto-oncogene can also be regulated at the translational level.
"]},{"key":"dc:title","label":"Title","values":["Translational Regulation of the C-Jun Proto-Oncogene"]}]}],"canonical_facts":{"dc:contributor":["Timothy J. Bos","Richard Stenberg","William Wasilenko","Frank Castora","Mark S. Elliot"],"dc:creator":["Sehgal, Anil"],"dc:date.available":["2019-10-16T07:00:00Z"],"dc:description.abstract":["The v-jun oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation. The c-Jun protein is a transcription factor which binds to the DNA target TGACTCA. The c-Jun protein binds to DNA in the form of dimers. It can form homodimers with itself and heterodimers with Jun family (JunB and JunD), Fos family (FosB, Fra1 and Fra2), or with CREB family members through the leucine zipper motif. Because the c-jun proto-oncogene plays an important role in cell transformation, extensive work has been done to understand how it is regulated. Previously, it has been shown that c-jun transcription can be activated by growth factors, tumor promoters and other oncogenes such as ras and src. Regulation of c-jun activity has been studied at the level of transcription, dimerization, DNA binding and post-translational modification. I report here that the c-jun proto-oncogene can also be regulated at the translational level.
"],"dc:identifier":["https://digitalcommons.odu.edu/biomedicalsciences_etds/130"],"dc:subject":["Oncogenes","Proto-oncogenes","Cell transformation","Cell Biology","Microbiology","Molecular Biology"],"dc:title":["Translational Regulation of the C-Jun Proto-Oncogene"],"thesis:degree_discipline":["Biological Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T03:35:23Z"}