Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 340 for “"oncogene"”.
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ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS
Oncogene Induced Senescence (OIS) is a tumor suppressive barrier that blocks cell cycle permanently. OIS results from a robust DNA damage response (DDR) activation due to oncogene-induced hyper-proliferation. By performing a whole genome analysis of DNA replication dynamics occurring upon oncogene …
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Oncogene-induced remodelling of cellular networks
… I introduce the concepts of evolution-driven oncogenesis, genetic and non-genetic heterogeneity and signal transduction pathways. In Chapter 2, I describe the characterisation of KRAS mutation-specific MAPK signalling. To do this, I generated an isogenic panel of cells stably expressing a FRET …
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Oncogene-Induced Signaling Heterogeneity in Lung Cancer
… has identified 138 frequently occurring driver oncogenes and tumor suppressor genes in lung cancer. Currently, only 15 of these genes can be targeted therapeutically. Study of downstream signaling alterations of these oncogenes and tumor suppressor genes may identify novel therapeutic targets. …
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Molecular characterization of the putative oncogene myeov
The myeov gene was identified using the tumorigenicity assay with DNA from a patient suffering a gastric carcinoma. The Myeov gene is localized at chromosome band 11q13, a frequent site for chromosomal rearrangements in various carcinomas and B-cell neoplasms. The gene was shown to be involved in …
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Oncogene-induced reprogramming of heterotypic cellular interactions
KRAS is a critical signalling hub that orchestrates fundamental cellular decisions such as cell survival, proliferation and differentiation. Activating mutations in KRAS are among the most frequently occurring oncogenic mutations driving cancers that are particularly refractory to therapy (e.g., …
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Activation of the c-Ha-ras oncogene
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 1984
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Oncogene-driven post-transcriptional regulation in lung cancer
Lung cancer is often caused by genetic mutations which alter the activity of proteins in the RAS family, with somatic mutation of the KRAS gene occurring in ~30% of lung adenocarcinoma tumors. A gene of the same family, RIT1, is mutated or amplified in 10-15% of lung adenocarcinomas. Although …
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Trim24 As An Oncogene In The Mammary Gland
… cells, consistent with TRIM24 function as an oncogene. We hypothesize that TRIM24 acts as an oncogene in the mammary gland.</p> <p>To test this hypothesis, we generated transgenic mice, which in the presence of cre-recombinase, conditionally over-express mouse TRIM24 fused to a C-terminal FLAG …
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Translational Regulation of the C-Jun Proto-Oncogene
<p>The <em>v-jun</em> oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation. The c-Jun protein is a transcription factor which binds to the DNA target TGACTCA. The …
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E2F1 induction following DNA damage and oncogene activation
… pRb, is deregulated in most human cancers. Oncogenes have been shown to deregulate E2F1 through inhibition of pRB and deregulation of E2F1 is an event that occurs in most human cancers. The essential role of E2F1 in apoptosis is well documented and deregulated E2F1 can enhance drug induced …
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Proto-oncogene Regulation by Growth Factors in Bone Cells
… molecular level, the expression of several proto-oncogenes was studied. IGF-I and IGF-II cause a rapid and transient induction of c-fos in MC3T3-E1 cells similar to that observed with other growth factors in other cell types. TGF-beta causes a similar rapid induction of c-fos which is slightly …
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Identification and Characterization of TONSL as an Immortalizing Oncogene
… findings reveal that TONSL is an immortalizing oncogene, capable of transforming primary breast epithelial cells in conjunction with defined oncogenes, resulting in Estrogen Receptor-positive breast adenocarcinomas. Furthermore, we observed that TONSL-amplified breast cancer cells are dependent …
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… transposons in mice, to model hepatocyte oncogene-induced senescence (OIS) combined with multiple downstream assays to interrogate four elements of adaptive senescence surveillance: functionality of T-helper subsets; their transcriptomic profile; antigen-reactivity; and adaptive …
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Taspase1 is a Non-oncogene Mediator of Tumorigenesis and Maintenance
The clinical success of oncogene-targeted therapies substantiates the continued reliance of certain cancers upon the continued function of apical oncogenes involved in its genesis--a phenomenon known as "oncogene addiction." Though this shift from non-targeted, cytotoxic therapies offers new hope …
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Translational mechanisms of stem cell fate regulation in epidermal oncogene tolerance
… the skin has exceptional capacity to tolerate oncogene hyperactivity. To date, we have made significant progress in understanding how homeostatic adult epidermis suppresses the expansion of individual clones derived from somatic mutations. However, the mechanisms behind oncogene tolerance …
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Predictive Reporter System for Investigating Dose Dependency in Oncogene-Induced Senescence
Oncogene-induced senescence (OIS) is a well-described autonomous tumour suppressor mechanism which removes cells harbouring oncogenic mutations from the proliferation pool. However, senescent cells remain metabolically active and express factors of the senescence-associated secretory phenotype …
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A mouse model to study inducible oncogene cooperation <i>in vivo</i>
… multiple changes occur in two kinds of genes: oncogenes and tumour suppressor genes.<br></br><br></br> Oncogene-products can be classified as growth factors, growth factor receptors, Ras oncoproteins, cytoplasmic protein kinases, transcription factors, anti-apoptotic proteins.<br></br><br></br> …
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Studies on signaling pathways induced by FLT3, an important oncogene in AML
FLT3, a receptor tyrosine kinase, is expressed in hematopoietic progenitor cells. FLT3-ITD (internal tandem duplication) and D835 mutations are found in approximately 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated …
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