Discriminative Stimulus Effects of Putative Antipsychotic Drugs

<p>This study attempted to further explore the discriminative stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do so reliably, however nine of ten rats trained to discriminate 1.25 mg/kg clozapine from vehicle were able to acquire the discrimination in 19.1 sessions. The clozapine cue partially generalized (63.13% drug lever responding [SEM = ± 18.91]) to the antimalarial drug methylene blue at the 7.5 mg/kg dose, but not to the antimalarial quinacrine. This study found that the antimalarial drug methylene blue may share some pharmacological similarities or subjective effects with that of clozapine, and further studies into its antipsychotic value, if any, should be explored.</p>

Name thesis:degree_name

Master of Science

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Psychological Science

Year dc:date.available

2019

Author dc:creator

• Lekander, Alex

Contributors dc:contributor

• Adam Prus

• antipsychotic
• chlorpromazine
• clozapine
• methylene blue
• quinacrine
• drug discrimination
• stimulus generalization
• Animal Studies
• Behavior and Behavior Mechanisms
• Experimental Analysis of Behavior

Repository record dc:identifier

https://commons.nmu.edu/theses/601

OAI identifier oai:identifier

oai:commons.nmu.edu:theses-1633