Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"chlorpromazine"”.
-
Repurposing chlorpromazine and its metabolites for antituberculosis drug discovery
… This study aimed to generate metabolites of chlorpromazine (CPZ), a phenothiazine with demonstrated in vitro activity against Mtb, and to investigate their potential utility in combination with anti-TB drugs. 7-HydroxyCPZ (M2), CPZ-N-oxide (M3), CPZ sulfoxide (M1), nor-CPZ (M5), nor-CPZ …
-
A State-Level Analysis of Deinstitutionalization and the Impact of Chlorpromazine
… time-series analysis to estimate the impact of chlorpromazine and policy changes on mental hospital population movement. To that end, the population movement of US state mental hospitals from 1925 to 1966 by state was analyzed. Furthermore, this study analyzes the overall resident count, …
-
The Use of ThorazineR (Chlorpromazine Hydrochloride) as an Aid to Analgesia and Amnesia During Labor and Delivery
With the present day practice of obstetrics, almost all women are given drugs of one type or another to relieve the pain of labor. Various medications, such as morphine, DemerolR, scopolomine, paraldehyde, and the barbiturates, have been employed alone or in combination. Because of the depressant …
-
The molecular structures of chlorpromazine and thiethylperazine and a discussion of the action mechanism of the phenothiazine derivatives
… psychiatry by Delay and Deniker in 1952 of chlorpromazine and its analogues has revolutionized the treatment of psychotic conditions and of mental diseases in general. Although the phenothiazines have been subjected to extensive clinical tests, their chemical structural features have not so …
-
A Clinical Investigation of the Use of Promazine Hydrochloride for Pre-Delivery Sedation
… which are those derived from phenothiazine. Chlorpromazine (Thorazine) has been used and reported extensively. Promethazine has received prominent attention, and for the last several years has been used routinely on the University Service at the Creighton Medical Center. These drugs used in …
-
Discriminative Stimulus Effects of Putative Antipsychotic Drugs
… by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do so reliably, however nine of ten rats trained to …
-
ΝΕΟΙ ΠΟΤΕΝΣΙΟΜΕΤΡΙΚΟΙ ΑΝΙΧΝΕΥΤΕΣ ΜΕ ΕΦΑΡΜΟΓΕΣ ΣΤΗ ΦΑΡΜΑΚΕΥΤΙΚΗ ΑΝΑΛΥΣΗ
… TO THE PHARMACEUTICAL COMPOUNDS SALICILATE, CHLORPROMAZINE, AMITRIPHYLINE, MEPERITINE, PROPANTHELINE, CIMEBILINE AND RANITIDINE. THESTUDY INCLUDED. 1) THE APPLICATION OF THESE ELECTRODES TO PHARMACEUTICAL ANALYSIS (DIRECT POTENTIOMETRY). 2) THE CALCULATION OF THE IONIZATION CONSTANT (KA) OF …
-
The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… failed to fully substitute for clozapine but chlorpromazine and thioridazine fully substituted for clozapine. This model does not differentiate between atypical and typical antipsychotic drugs but it may be useful in the detection of antipsychotics with potent serotonin and α1 adrenergic …
-
Anticholinergic Impact On Cognition In Schizophrenia
… These same analyses were performed comparing chlorpromazine equivalents and again there were no statistically significant results. Our results suggest that the anticholinergic load or dose of antipsychotic medication do not significantly contribute to cognitive deficits in patients with …
-
Understanding Bacterial Resistance and Dissemination: The Impact of Biocide Priming
… Efflux pump inhibitors (thioridazine and chlorpromazine) were used to investigate efflux as a mechanism. Known antibiotic resistance genes were sequenced to look for any mutations and Quantitative Realtime PCR was used to compare their regulation and expression between parent and primed …
-
The Role of Escherichia Coli Endotoxins in The Pathogenesis of Lactation Failure in The Sow
… blocking agents, haloperidol (10 mg/sow) and chlorpromazine (0.5 mg/kg), were ineffective in elevating PRL concentrations when given on PP + 5 or PP + 6. TRH (500 (mu)g IM) elevated PRL for 20-30 minutes. These results suggested that PRL is not under chronic inhibitory control by the …
-
A Study of the Interaction of Copper with Selected Psychotropic Compounds
… control of the symptoms of schizophrenia, chlorpromazine being the best known member. Both classes of compounds act via dopamine systems in the brain and one of the active enzymes in the brain bringing about the removal of dopamine, dopamine β-hydroxylase, contains copper. Both classes have …
-
Polymer Electrolytes For lontophoretic Drug Delivery
… sodium, thiamine hydrochloride, lithium citrate, chlorpromazine hydrochloride and lithium chloride have been incorporated into PEO using both water and an acetonitrile/ethanol mixture as casting solvents to form films. The thermal, optical and electrical properties of these films using …
-
Purification and Activity of the PP60SRC Protein Kinase
… was inhibited by the calmodulin inhibitor chlorpromazine. The Ca<sup>2+</sup>-calmodulin activated phosphorylation of the 50 kD protein is not pp60<sup>src</sup>- induced since it occurs to a significant extent in samples prepared from non-transformed chick embryo cells. Several experiments …
-
Discriminative stimulus properties of 3-substituent rimonabant analogs
… through a nicotinic mechanism. Tests with chlorpromazine, an antipsychotic that is a false positive in the tetrad, and diazepam, which produces partial substitution for THC’s discriminative stimulus through a GABAergic mechanism are also planned.
-
Cyclic and Linear Cell-Penetarating Peptides Composed of Tryptophan (WW) and Arginine (RR) Residues as Molecular Transporters
… the lowest cellular uptake in the presence of chlorpromazine, indicating that the uptake was mostly dependent on the clathrin-mediated pathway. These data provide insight into the designing of the next generation of cell-penetrating peptides.</p>
-
Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Tools and Antimicrobial Agents
… of endocytosis inhibitors such as nystatin, chlorpromazine, chloroquine, and methyl β-cyclodextrin suggesting that the uptake for [DipR]<sub>5</sub> may not be endocytosis-dependent. Circular dichroism, dynamic light scattering, and transmission electron microscopy were utilized to determine …
-
Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
… uptake of F′-(RWRW3)2 in the presence of chlorpromazine and methyl- β-cyclodextrin was reduced but not eliminated, indicating that both energy-dependent VI and energy-independent pathways contributed to the cellular uptake of F′-(RWRW3)2. This data indicates that (RWRW3)2 can be used as a …
-
Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positive and Hydrophobic Residues as Molecular Transporters
… was partially inhibited by chlorpromazine endocytosis inhibitors after 3 h incubation in MDA-MB-231 cells, which suggests the partial uptake through the clathrin-mediated endocytosis pathway. Intracellular localization (mostly in the cytosol) of …
-
Spontaneous Raman spectroscopy: Exploring applicability in drug discovery and the medical sciences
… of lysosomally trapped compounds (chloroquine, chlorpromazine) was achieved. The detection of substances without a signal in the CSR was achieved without enhancement. Nonetheless, compounds with intrinsic peaks in the CSR could benefit from this enhancement.<br/><br/>Lastly the RS system is …
Page 1 of 2