Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"clozapine"”.
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Clozapine in Treatment-Resistant Schizophrenia (TRS): improving access and utilisation
… termed treatment-refractory schizophrenia (TRS). Clozapine is the only licensed and recognised effective treatment in TRS. Interestingly, rather than its current position as a third-line treatment, there are rather robust and convincing arguments for clozapine to be used as a second line. Sadly, …
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The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… to atypical antipsychotic drug effects. Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic haloperidol …
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Neuropsychological and biological mechanisms of checking in OCD and clozapine induced Schizo-OCS
… the second generation antipsychotic medication clozapine. Particular focus is placed on compulsive checking behaviours and their relationship to current theories of compulsivity based on the hypothesis of imbalance between the goal-directed and habit systems and aberrant prediction-error …
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Investigating Clozapine-Induced Myocarditis in Stem Cell-Derived Cardiomyocytes from Treatment-Resistant Schizophrenia Patients: A Pharmacoepigenomic Approach
Clozapine, an antipsychotic with proven efficacy for treatment-resistant schizophrenia, is often underutilized due to the risk of severe side effects such as myocarditis (cardiac inflammation). This study explores whether epigenetic regulation may predispose individuals to clozapine-induced …
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A psychophysiological investigation of the effects of a psychotropic agent (clozapine) upon sleep parameters of normal young adults
… 1969(a)(b)). Recent research has suggested that clozapine, a psychotropic agent, may have pronounced sleep inducing properties (Hemphill et al 1975; Ruch et al 1976; Gross and Langner 1966,1969; Berzewski et al 1969). However, its role as an hypnotic agent has yet to be systematically …
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La clozapine et les neurostéroïdes dans la modulation de comportements associés au suicide dans un modèle murin de schizophrénie
… by adolescent social isolation). In this model, clozapine normalized prepulse inhibition, aggressiveness, impulsivity and anxietylike behaviours in THMS mice. While the basis of clozapine superior effectiveness on suicidal behaviors in schizophrenic patients is not well understood, previous works …
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The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg Hospital
… the amount of evidence suggesting a link between clozapine and metabolic syndrome, several guidelines have recommended regular clinical monitoring of metabolic syndrome in patients on clozapine. Aim: To determine the screening, prevalence and associated risk factors of metabolic disorders in …
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Investigation of potential biomarkers of treatment-resistant schizophrenia
… this diagnosis which often takes many years. Clozapine remains the gold standard treatment for people with TRS where other antipsychotics have failed. Yet its use is limited by potentially fatal side effects and there is still a subset, approximately 50- 70% of patients treated with clozapine, …
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The impact of antipsychotic drugs on the expression of genes associated with obesity
… second generation antipsychotic drugs such as clozapine. The mechanism behind clozapine-induced weight gain remains poorly understood, but changes in eating behaviour and energy homeostasis may be involved. Recently, genome-wide association studies have identified a number of …
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Discriminative Stimulus Effects of Putative Antipsychotic Drugs
… and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do so reliably, however nine of ten rats trained to discriminate 1.25 mg/kg clozapine from vehicle were able …
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Genetic association between schizophrenia and type-2 diabetes
… schizophrenia and T2D, and to explore whether clozapine could affect expression of the genes associated with obesity and T2D.<br/>Methods: A total of 221 British nuclear families consisting of 148 fathers, 204 mothers and 222 affected offspring with schizophrenia were recruited for the genetic …
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Management of Treatment-Resistant Schizophrenia
… classes or different generic forms, the use of Clozapine, benzodiazepines, cognitive behavioral therapy, psychotherapy and social therapy.
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Studies into Amphetamine-Induced Unconditioned Behaviour in the Rat.
… (haloperidol), the atypical antipsychotics (clozapine and sulpiride) and a putative antipsychotic (a 5-HT3 antagonist, ondansetron) on open-field locomotor routes taken by rats following treatment with 3.5mg/kg amphetamine. Measures of stereotyped locomotion derived from image analysis were …
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Exploration of cognitive and neurochemical deficits in an animal model of schizophrenia. Investigation into sub-chronic PCP-induced cognitive deficits using behavioural, neurochemical and electrophysiological techniques; and use of receptor-selective agents to study the pharmacology of antipsychotics in female rats.
… attenuated by sub-chronic administration of clozapine and risperidone, but not haloperidol. The effect of PCP was also shown to be more robust in female rats compared to males. A deficit in set-shifting ability was also observed in isolation reared rats. However, the deficits produced by PCP …
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Cationic amphiphilic drug-induced autophagosome accumulation is due to autophagosome sequestration within vimentin intermediate filament networks resulting in prolonged autophagosome half-life
… drugs (CADs) U18666A, imipramine and clozapine caused</p> <p>lysosomal non-esterified cholesterol and autophagosome accumulation.</p> <p>Measurement of LC3-II conversion in the presence of lysosomal inhibitors</p> <p>bafilomycin A1 and NH4Cl, degradation of long-lived proteins, and</p> …
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A Genetic Analysis of the Relationship between Gluten Intolerance and Schizophrenia
… treatment with 1 μg/ml of the neuroleptic drug clozapine.<br/>This study concludes that the major genetic factors underlying schizophrenia and CD are distinct, and that the gluten response observed in schizophrenia does not follow the classical CD pathway. Furthermore, this study provides …
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A descriptive analysis of antipsychotic prescribing patterns for patients admitted to hospital with a primary diagnosis of schizophrenia
… pending eligibility, patients were prescribed clozapine as a third-line treatment. Length of stay as well as race/ethnicity were associated with an increased likelihood of receiving treatment with an LAI, however there are a number of unobservable confounding variables which make it difficult …
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Improving care coordination through virtual warm handoffs in telepsychiartry
… on medications like lithium, valproate, or clozapine that require specific monitoring as per guidelines. Purpose: This QI/EBP DNP project assessed whether implementing a structured provider-to-nurse SBAR handoff would enhance the completion of nursing assessments in a community outpatient …
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Enhanced striatal glutamatergic function upon chronic antipsychotic action
… of one especially effective antipsychotic, clozapine. Furthermore, we find that striatal astrocytes also respond to chronic antipsychotic treatment with translational alterations promoting synaptogenesis. Together, these data have identified a core molecular signature of increased …
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