ΜΗΧΑΝΙΣΜΟΙ ΟΓΚΟΓΕΝΕΣΗΣ ΔΙΑ ΤΟΥ ΛΕΥΧΑΙΜΟΓΟΝΟΥ ΙΟΥ ΤΟΥ MOLONEY (MOMULV)

MOLONEY MURINE LEUKEMIA VIRUS (MOMULV) IS A RETROVIRUS WHICH LACKS AN ONCOGENE.HOWEVER IT IS HIGHLY ONCOGENIC IN RATS AND MICE IN WHICH IT INDUCES THYMIC LYMPHOMAS. THESE LYMPHOMAS ARE CLONAL TUMORS AND APPEAR FOUR TO SIX MONTHS FOLLOWING VIRUS INOCULATION. THE PHENOTYPE OF THESE TUMORS CORRESPONDS TO ALL THE STAGES OF T CELL DIFFERENTIATION. THE PROCESS OF ONCOGENESIS IN BOTH ITS EARLY AND LATE STAGES IS DUE TO PROVIRUS MEDIATES INSERTIONAL MUTAGENESIS. USING THE INTEGRATED PROVIRUS AS A MARKER WE HAVE IDENTIFIED AND CHARACTERIZED FIVE INDEPENDENT LOCI TOUR OF WHICH (MEVI-1,2,3,4) ARE INVOLVED IN TUMOR INDUCTION WHILE THE FIFTH ONE (TPL-1) IS INVOLVED IN TUMOR PROGRESSION.

Grantor dc:publisher

University of Patras

Year dc:date

1989

Author dc:creator

• Τσιχλής, Φίλιππος

• ACTIVATION OF ONCOGENES
• INSERTIONAL MUTOGENESIS
• LEUKOGENIC VIRUS
• MOLONEY VIRUS
• Oncogenes
• Oncogenesis
• ONCOVIRUS
• RETROVIRUS
• T cell lymphomas
• Thymoma
• ΕΝΕΡΓΟΠΟΙΗΣΗ ΟΓΚΟΓΟΝΙΔΙΩΝ
• Θύμωμα
• ΙΟΣ ΤΟΥ MOLONEY
• ΛΕΜΦΩΜΑΤΑ ΤΩΝ Τ ΛΕΜΦΩΚΥΤΤΑΡΩΝ
• ΛΕΥΧΑΙΜΟΓΟΝΟΣ ΙΟΣ
• ΜΕΤΑΛΑΞΗ ΕΞ ΕΙΣΑΓΩΓΗΣ
• Ογκογένεση
• Ογκογονίδια
• ΟΓΚΟΙΟΣ
• Ρετροϊός
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1053

OAI identifier oai:identifier

oai:10442/1053