{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1053"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1053","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΜΗΧΑΝΙΣΜΟΙ ΟΓΚΟΓΕΝΕΣΗΣ ΔΙΑ ΤΟΥ ΛΕΥΧΑΙΜΟΓΟΝΟΥ ΙΟΥ ΤΟΥ MOLONEY (MOMULV)","abstract":"MOLONEY MURINE LEUKEMIA VIRUS (MOMULV) IS A RETROVIRUS WHICH LACKS AN ONCOGENE.HOWEVER IT IS HIGHLY ONCOGENIC IN RATS AND MICE IN WHICH IT INDUCES THYMIC LYMPHOMAS. THESE LYMPHOMAS ARE CLONAL TUMORS AND APPEAR FOUR TO SIX MONTHS FOLLOWING VIRUS INOCULATION. THE PHENOTYPE OF THESE TUMORS CORRESPONDS TO ALL THE STAGES OF T CELL DIFFERENTIATION. THE PROCESS OF ONCOGENESIS IN BOTH ITS EARLY AND LATE STAGES IS DUE TO PROVIRUS MEDIATES INSERTIONAL MUTAGENESIS. USING THE INTEGRATED PROVIRUS AS A MARKER WE HAVE IDENTIFIED AND CHARACTERIZED FIVE INDEPENDENT LOCI TOUR OF WHICH (MEVI-1,2,3,4) ARE INVOLVED IN TUMOR INDUCTION WHILE THE FIFTH ONE (TPL-1) IS INVOLVED IN TUMOR PROGRESSION.","abstract_html":"MOLONEY MURINE LEUKEMIA VIRUS (MOMULV) IS A RETROVIRUS WHICH LACKS AN ONCOGENE.HOWEVER IT IS HIGHLY ONCOGENIC IN RATS AND MICE IN WHICH IT INDUCES THYMIC LYMPHOMAS. THESE LYMPHOMAS ARE CLONAL TUMORS AND APPEAR FOUR TO SIX MONTHS FOLLOWING VIRUS INOCULATION. THE PHENOTYPE OF THESE TUMORS CORRESPONDS TO ALL THE STAGES OF T CELL DIFFERENTIATION. THE PROCESS OF ONCOGENESIS IN BOTH ITS EARLY AND LATE STAGES IS DUE TO PROVIRUS MEDIATES INSERTIONAL MUTAGENESIS. USING THE INTEGRATED PROVIRUS AS A MARKER WE HAVE IDENTIFIED AND CHARACTERIZED FIVE INDEPENDENT LOCI TOUR OF WHICH (MEVI-1,2,3,4) ARE INVOLVED IN TUMOR INDUCTION WHILE THE FIFTH ONE (TPL-1) IS INVOLVED IN TUMOR PROGRESSION.","abstract_has_math":false,"creators":["Τσιχλής, Φίλιππος"],"institution":"University of Patras","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1989,"date_issued":"1989","date_published":"1989","updated_at":"2026-07-24T02:24:43Z","subjects":["ACTIVATION OF ONCOGENES","INSERTIONAL MUTOGENESIS","LEUKOGENIC VIRUS","MOLONEY VIRUS","Oncogenes","Oncogenesis","ONCOVIRUS","RETROVIRUS","T cell lymphomas","Thymoma","ΕΝΕΡΓΟΠΟΙΗΣΗ ΟΓΚΟΓΟΝΙΔΙΩΝ","Θύμωμα","ΙΟΣ ΤΟΥ MOLONEY","ΛΕΜΦΩΜΑΤΑ ΤΩΝ Τ ΛΕΜΦΩΚΥΤΤΑΡΩΝ","ΛΕΥΧΑΙΜΟΓΟΝΟΣ ΙΟΣ","ΜΕΤΑΛΑΞΗ ΕΞ ΕΙΣΑΓΩΓΗΣ","Ογκογένεση","Ογκογονίδια","ΟΓΚΟΙΟΣ","Ρετροϊός","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1053"],"render_values":[{"text":"10.12681/eadd/1053","href":"https://doi.org/10.12681/eadd/1053","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1053","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Τσιχλής, Φίλιππος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1989"]},{"key":"dc:publisher","label":"Institution","values":["University of Patras","Πανεπιστήμιο Πατρών"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ACTIVATION OF ONCOGENES","INSERTIONAL MUTOGENESIS","LEUKOGENIC VIRUS","MOLONEY VIRUS","Oncogenes","Oncogenesis","ONCOVIRUS","RETROVIRUS","T cell lymphomas","Thymoma","ΕΝΕΡΓΟΠΟΙΗΣΗ ΟΓΚΟΓΟΝΙΔΙΩΝ","Θύμωμα","ΙΟΣ ΤΟΥ MOLONEY","ΛΕΜΦΩΜΑΤΑ ΤΩΝ Τ ΛΕΜΦΩΚΥΤΤΑΡΩΝ","ΛΕΥΧΑΙΜΟΓΟΝΟΣ ΙΟΣ","ΜΕΤΑΛΑΞΗ ΕΞ ΕΙΣΑΓΩΓΗΣ","Ογκογένεση","Ογκογονίδια","ΟΓΚΟΙΟΣ","Ρετροϊός","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1053","http://hdl.handle.net/10442/hedi/1053"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["MOLONEY MURINE LEUKEMIA VIRUS (MOMULV) IS A RETROVIRUS WHICH LACKS AN ONCOGENE.HOWEVER IT IS HIGHLY ONCOGENIC IN RATS AND MICE IN WHICH IT INDUCES THYMIC LYMPHOMAS. THESE LYMPHOMAS ARE CLONAL TUMORS AND APPEAR FOUR TO SIX MONTHS FOLLOWING VIRUS INOCULATION. THE PHENOTYPE OF THESE TUMORS CORRESPONDS TO ALL THE STAGES OF T CELL DIFFERENTIATION. THE PROCESS OF ONCOGENESIS IN BOTH ITS EARLY AND LATE STAGES IS DUE TO PROVIRUS MEDIATES INSERTIONAL MUTAGENESIS. USING THE INTEGRATED PROVIRUS AS A MARKER WE HAVE IDENTIFIED AND CHARACTERIZED FIVE INDEPENDENT LOCI TOUR OF WHICH (MEVI-1,2,3,4) ARE INVOLVED IN TUMOR INDUCTION WHILE THE FIFTH ONE (TPL-1) IS INVOLVED IN TUMOR PROGRESSION.","Ο ΛΕΥΧΑΙΜΟΓΟΝΟΣ ΙΟΣ ΤΟΥ MALONEY ΕΙΝΑΙ ΕΝΑΣ ΡΕΤΡΟΙΟΣ Ο ΟΠΟΙΟΣ ΣΤΕΡΕΙΤΑΙ ΟΓΚΟΓΟΝΙΔΙΟΥ. ΠΑΡ'ΟΛΑ ΑΥΤΑ ΕΧΕΙ ΤΗ ΔΥΝΑΤΟΤΗΤΑ ΝΑ ΠΡΟΚΑΛΕΙ ΚΑΚΟΗΘΗ ΝΕΟΠΛΑΣΜΑΤΑ (ΛΕΜΦΩΜΑΤΑ) ΤΟΥ ΘΥΜΟΥ ΑΔΕΝΑ ΣΤΟΥΣ ΑΡΟΥΡΑΙΟΥΣ ΚΑΙ ΤΟΥΣ ΠΟΝΤΙΚΟΥΣ. ΑΥΤΑ ΤΑ ΛΕΜΦΩΜΑΤΑ ΕΧΟΥΝΚΛΙΝΙΚΗ ΠΡΟΕΛΕΥΣΗ ΚΑΙ ΕΜΦΑΝΙΖΟΝΤΑΙ 4-6 ΜΗΝΕΣ ΜΕΤΑ ΤΗΝ ΕΝΕΣΗ ΤΟΥ ΙΟΥ. Ο ΦΑΙΝΟΤΥΠΟΣ ΤΩΝ ΟΓΚΩΝ ΑΥΤΩΝ ΤΟΥΣ ΚΑΤΑΤΑΣΣΕΙ ΣΕ ΟΛΕΣ ΤΙΣ ΒΑΘΜΙΔΕΣ ΤΟΥ ΦΑΣΜΑΤΟΣ ΔΙΑΦΟΡΟΠΟΙΗΣΗΣ ΤΩΝ Τ ΛΕΜΦΩΚΥΤΤΑΡΩΝ. Η ΠΟΡΕΙΑ ΤΗΣ ΟΓΚΟΓΕΝΕΣΗΣ ΑΡΧΙΖΕΙ ΚΑΙ ΣΥΝΕΧΙΖΕΤΑΙ ΜΕ ΜΕΤΑΛΑΞΕΙΣ ΕΞ ΕΙΣΑΓΩΓΗΣ ΠΟΥ ΟΦΕΙΛΟΝΤΑΙ ΣΤΗΝ ΕΝΣΩΜΑΤΩΣΗ ΤΟΥ DNA ΤΟΥ ΙΟΥ ΜΕΣΑ ΣΤΟΓΕΝΕΤΙΚΟ ΥΛΙΚΟ ΤΟΥ ΚΥΤΤΑΡΟΥ. ΧΡΗΣΙΜΟΠΟΙΩΝΤΑΣ ΤΟΝ ΙΟ ΣΑΝ ΔΕΙΚΤΗ ΕΧΟΥΜΕ ΑΝΑΓΝΩΡΙΣΕΙ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΕΙ ΠΕΝΤΕ ΓΕΝΕΤΙΚΟΥΣ ΤΟΠΟΥΣ ΑΠΟ ΤΟΥΣ ΟΠΟΙΟΥΣ ΟΙ ΤΕΣΣΕΡΕΙΣ (MLVI-1,2,3,4) ΕΧΟΥΝ ΣΧΕΣΗ ΜΕ ΤΑ ΑΡΧΙΚΑ ΣΤΑΔΙΑ ΤΗΣ ΟΓΚΟΓΕΝΕΣΗΣ ΚΑΙ Ο ΠΕΜΠΤΟΣ (TPL-1) ΕΧΕΙ ΣΧΕΣΗ ΜΕ ΤΗΝ ΠΡΟΟΔΟ ΤΟΥ ΟΓΚΟΥ ΣΤΑ ΤΕΛΕΥΤΑΙΑ ΣΤΑΔΙΑ ΤΗΣ ΟΓΚΟΓΕΝΕΣΗΣ."]},{"key":"dc:title","label":"Title","values":["ΜΗΧΑΝΙΣΜΟΙ ΟΓΚΟΓΕΝΕΣΗΣ ΔΙΑ ΤΟΥ ΛΕΥΧΑΙΜΟΓΟΝΟΥ ΙΟΥ ΤΟΥ MOLONEY (MOMULV)","MECHANISMS OF ONCOGENESIS BY MOLONEY MURINE LEUKEMIA VIRUS (MOMULV)"]}]}],"canonical_facts":{"dc:creator":["Τσιχλής, Φίλιππος"],"dc:date":["1989"],"dc:description":["MOLONEY MURINE LEUKEMIA VIRUS (MOMULV) IS A RETROVIRUS WHICH LACKS AN ONCOGENE.HOWEVER IT IS HIGHLY ONCOGENIC IN RATS AND MICE IN WHICH IT INDUCES THYMIC LYMPHOMAS. THESE LYMPHOMAS ARE CLONAL TUMORS AND APPEAR FOUR TO SIX MONTHS FOLLOWING VIRUS INOCULATION. THE PHENOTYPE OF THESE TUMORS CORRESPONDS TO ALL THE STAGES OF T CELL DIFFERENTIATION. THE PROCESS OF ONCOGENESIS IN BOTH ITS EARLY AND LATE STAGES IS DUE TO PROVIRUS MEDIATES INSERTIONAL MUTAGENESIS. USING THE INTEGRATED PROVIRUS AS A MARKER WE HAVE IDENTIFIED AND CHARACTERIZED FIVE INDEPENDENT LOCI TOUR OF WHICH (MEVI-1,2,3,4) ARE INVOLVED IN TUMOR INDUCTION WHILE THE FIFTH ONE (TPL-1) IS INVOLVED IN TUMOR PROGRESSION.","Ο ΛΕΥΧΑΙΜΟΓΟΝΟΣ ΙΟΣ ΤΟΥ MALONEY ΕΙΝΑΙ ΕΝΑΣ ΡΕΤΡΟΙΟΣ Ο ΟΠΟΙΟΣ ΣΤΕΡΕΙΤΑΙ ΟΓΚΟΓΟΝΙΔΙΟΥ. ΠΑΡ'ΟΛΑ ΑΥΤΑ ΕΧΕΙ ΤΗ ΔΥΝΑΤΟΤΗΤΑ ΝΑ ΠΡΟΚΑΛΕΙ ΚΑΚΟΗΘΗ ΝΕΟΠΛΑΣΜΑΤΑ (ΛΕΜΦΩΜΑΤΑ) ΤΟΥ ΘΥΜΟΥ ΑΔΕΝΑ ΣΤΟΥΣ ΑΡΟΥΡΑΙΟΥΣ ΚΑΙ ΤΟΥΣ ΠΟΝΤΙΚΟΥΣ. ΑΥΤΑ ΤΑ ΛΕΜΦΩΜΑΤΑ ΕΧΟΥΝΚΛΙΝΙΚΗ ΠΡΟΕΛΕΥΣΗ ΚΑΙ ΕΜΦΑΝΙΖΟΝΤΑΙ 4-6 ΜΗΝΕΣ ΜΕΤΑ ΤΗΝ ΕΝΕΣΗ ΤΟΥ ΙΟΥ. Ο ΦΑΙΝΟΤΥΠΟΣ ΤΩΝ ΟΓΚΩΝ ΑΥΤΩΝ ΤΟΥΣ ΚΑΤΑΤΑΣΣΕΙ ΣΕ ΟΛΕΣ ΤΙΣ ΒΑΘΜΙΔΕΣ ΤΟΥ ΦΑΣΜΑΤΟΣ ΔΙΑΦΟΡΟΠΟΙΗΣΗΣ ΤΩΝ Τ ΛΕΜΦΩΚΥΤΤΑΡΩΝ. Η ΠΟΡΕΙΑ ΤΗΣ ΟΓΚΟΓΕΝΕΣΗΣ ΑΡΧΙΖΕΙ ΚΑΙ ΣΥΝΕΧΙΖΕΤΑΙ ΜΕ ΜΕΤΑΛΑΞΕΙΣ ΕΞ ΕΙΣΑΓΩΓΗΣ ΠΟΥ ΟΦΕΙΛΟΝΤΑΙ ΣΤΗΝ ΕΝΣΩΜΑΤΩΣΗ ΤΟΥ DNA ΤΟΥ ΙΟΥ ΜΕΣΑ ΣΤΟΓΕΝΕΤΙΚΟ ΥΛΙΚΟ ΤΟΥ ΚΥΤΤΑΡΟΥ. ΧΡΗΣΙΜΟΠΟΙΩΝΤΑΣ ΤΟΝ ΙΟ ΣΑΝ ΔΕΙΚΤΗ ΕΧΟΥΜΕ ΑΝΑΓΝΩΡΙΣΕΙ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΕΙ ΠΕΝΤΕ ΓΕΝΕΤΙΚΟΥΣ ΤΟΠΟΥΣ ΑΠΟ ΤΟΥΣ ΟΠΟΙΟΥΣ ΟΙ ΤΕΣΣΕΡΕΙΣ (MLVI-1,2,3,4) ΕΧΟΥΝ ΣΧΕΣΗ ΜΕ ΤΑ ΑΡΧΙΚΑ ΣΤΑΔΙΑ ΤΗΣ ΟΓΚΟΓΕΝΕΣΗΣ ΚΑΙ Ο ΠΕΜΠΤΟΣ (TPL-1) ΕΧΕΙ ΣΧΕΣΗ ΜΕ ΤΗΝ ΠΡΟΟΔΟ ΤΟΥ ΟΓΚΟΥ ΣΤΑ ΤΕΛΕΥΤΑΙΑ ΣΤΑΔΙΑ ΤΗΣ ΟΓΚΟΓΕΝΕΣΗΣ."],"dc:identifier":["10.12681/eadd/1053","http://hdl.handle.net/10442/hedi/1053"],"dc:language":["gre"],"dc:publisher":["University of Patras","Πανεπιστήμιο Πατρών"],"dc:subject":["ACTIVATION OF ONCOGENES","INSERTIONAL MUTOGENESIS","LEUKOGENIC VIRUS","MOLONEY VIRUS","Oncogenes","Oncogenesis","ONCOVIRUS","RETROVIRUS","T cell lymphomas","Thymoma","ΕΝΕΡΓΟΠΟΙΗΣΗ ΟΓΚΟΓΟΝΙΔΙΩΝ","Θύμωμα","ΙΟΣ ΤΟΥ MOLONEY","ΛΕΜΦΩΜΑΤΑ ΤΩΝ Τ ΛΕΜΦΩΚΥΤΤΑΡΩΝ","ΛΕΥΧΑΙΜΟΓΟΝΟΣ ΙΟΣ","ΜΕΤΑΛΑΞΗ ΕΞ ΕΙΣΑΓΩΓΗΣ","Ογκογένεση","Ογκογονίδια","ΟΓΚΟΙΟΣ","Ρετροϊός","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"dc:title":["ΜΗΧΑΝΙΣΜΟΙ ΟΓΚΟΓΕΝΕΣΗΣ ΔΙΑ ΤΟΥ ΛΕΥΧΑΙΜΟΓΟΝΟΥ ΙΟΥ ΤΟΥ MOLONEY (MOMULV)","MECHANISMS OF ONCOGENESIS BY MOLONEY MURINE LEUKEMIA VIRUS (MOMULV)"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:43Z"}