Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"Oncogenesis"”.
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Strategies for Oncogenesis by Avian Leukosis Viruses
<p>The mechanism of oncogenesis by avian leukosis viruses (ALVs) was examined. ALVs are slowly transforming RNA tumor viruses that do not transform cells in tissue culture and that cause neoplastic disease only after a latent period of 4-12 months. ALVs generally induce widely disseminating B cell …
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From Oncogenesis to Immunotherapy: Mathematical Modeling of Heterogeneous Cancers
We utilize mathematical modeling to study two types of cancer with substantial mutational heterogeneity: chronic lymphocytic leukemia (CLL) and mismatch-repair deficient colorectal cancer (MMR-D CRC). First, to study the progression of CLL into an aggressive lymphoma, Richter’s Syndrome (RS), we …
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Molecular Mechanism of Aurora-A Kinase in Human Oncogenesis
… imbalance of which may contribute to human oncogenesis. Using yeast 2-hybrid screening, we identified a splicing form of CNTD2 as Aurora-A interacting protein. CNTD2 locates to chromosome 19q13.2 AKT2 amplicon. CNTD2 is amplified and overexpressed in human ovarian, pancreatic and lung cancer …
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Regulation of Ras signaling and oncogenesis by plasma membrane microdomains
In this study, we assessed the contributions of plasma membrane (PM) microdomain targeting to the functions of H-Ras and R-Ras. These paralogues have identical effector-binding regions, but variant C-terminal targeting domains (tDs) which are responsible for lateral microdomain distribution: …
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A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis
… the molecular mechanisms of aneuploidy during oncogenesis in order to reconcile the different effects of karyotype alteration in untransformed and cancer cells. In this thesis, we first investigate the mechanism by which untransformed cells harboring highly complex karyotypes trigger a natural …
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The novel long noncoding RNA lncUSMycN in N-Myc-induced oncogenesis
One of the worst subtypes of neuroblastoma is caused by the amplification of a 130 kb genomic DNA region containing the MYCN oncogene. While MYCN has been extensively investigated, it is unknown whether other genomic elements within the 130 kb amplicon play a role in neuroblastoma. In this study, I …
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TCF4 Is a Key Mediator of Cell Identity and Oncogenesis in Neuroblastoma
… crest developmental programs contributes to NB oncogenesis by retaining the highly migratory and proliferative traits of NCCs. Thus, activation or repression of neural crest developmental pathways have been implicated in NB pathogenesis. Recent data reported two identities in neuroblastoma cell …
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Identifying unique cell states in early liver oncogenesis with transcription coupled repair
Many cancers, such as the main form of primary liver cancer hepatocellular carcinoma (HCC), typically arise in tissues with a high number of genetic mutations which drive cell growth aberrantly. These mutations appear to precede tumour initiation, as DNA sequencing has shown that cancer driver …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… By performing comparative analyses between oncogenesis and homeostasis, I reveal that the presence of oncogenic clones induces a systemic injury response in wildtype AT2 cells, causing accelerated proliferation and differentiation through a similar state previously reported to be an …
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The Art of Viral Oncogenesis: Lessons from Human Papillomavirus and Polyomavirus Transformed Cancers
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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A Role for the Phosphoinositide Lipid Kinase PI4KIIIbeta in Breast Oncogenesis and Akt Activation
… is to investigate a role for PI4KIIIβ in breast oncogenesis. We show that PI4KIIIβ is highly expressed in approximately 20% of primary human breast tumours. Overexpression of PI4KIIIβ in an invasive breast ductal carcinomas cell line, BT549, increased the production of filopodial actin filament …
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MODELING COHESIN-DEPENDENT ONCOGENESIS IN VITRO AND IN VIVO: POSSIBLE AMELIORATIVE EFFECTS OF PARP INHIBITION
The cohesin complex performs essential cellular functions including regulation of chromosome cohesion, chromatin 3D architecture and DNA repair. Somatic pathogenetic variants in cohesin genes have been associated with tumorigenesis but it is unclear their contribution to brain tumors. Hence, I …
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The role of cellular micro-RNAs in Epstein-Barr virus induced cellular transformation and oncogenesis
Micro-RNAs (miRNAs) are a class of non-coding RNA which post-transcriptionally regulate gene expression. Epstein-Barr Virus (EBV) transforms resting B-cells in vitro to establish continuously proliferating lymphoblastoid cell lines (LCLs) and is aetiologically linked to lymphomas. Little is known …
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An investigation of the mechanism of PAX7 mediated oncogenesis via in silico and in vitro biology
… mechanism or mechanisms of PAX7 mediated oncogenesis. This was achieved by: Systematic searches for cis conserved sequences within PAX7 intronic regions, which may be implicated in aberrant PAX7 expression in tumours; Comparison of conserved putative cis elements in human, mouse, chick and …
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STING safeguards epithelial genome integrity and protects from carcinogenesis via mitotic checkpoint control
… contributes to cell-intrinsic prevention of oncogenesis is not known. The present work uncovers a novel role and identifies STING as an epithelial, interferon-independent genome-integrity checkpoint that couples DNA damage signaling to cell-cycle control, thereby restraining chromosomal …
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Identifying Novel Interactions Between Human Ubiquitin-Specific Protease 7 (USP7) and Histone Methylating/Demethylating Proteins
… histone modifying enzymes highly implicated in oncogenesis, Enhancer of Zeste Homolog 2 (EZH2) and Retinoblastoma Binding Protein 2 (RBP2). Based on previous findings, our group identified probable interaction sites in these proteins and pursued to characterize the interactions and regulatory …
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ΜΗΧΑΝΙΣΜΟΙ ΟΓΚΟΓΕΝΕΣΗΣ ΔΙΑ ΤΟΥ ΛΕΥΧΑΙΜΟΓΟΝΟΥ ΙΟΥ ΤΟΥ MOLONEY (MOMULV)
… STAGES OF T CELL DIFFERENTIATION. THE PROCESS OF ONCOGENESIS IN BOTH ITS EARLY AND LATE STAGES IS DUE TO PROVIRUS MEDIATES INSERTIONAL MUTAGENESIS. USING THE INTEGRATED PROVIRUS AS A MARKER WE HAVE IDENTIFIED AND CHARACTERIZED FIVE INDEPENDENT LOCI TOUR OF WHICH (MEVI-1,2,3,4) ARE INVOLVED IN …
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Regulation of sphingosine kinase 1 oncogenic signalling by calcium and integrin binding proteins
… members of the CIB family, may contribute to oncogenesis through regulating the subcellular localisation of SK1. In light of this, the studies detailed in this thesis aimed to examine if and how CIB family proteins are involved in cancer via the regulation of SK1. In this study, by mining gene …
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Chromatin Architecture Aberrations Contribute and Acute Lymphoblastic Leukemia Relapse
… domains and compartments, is largely stable over oncogenesis but that small-scale focal chromatin interactions change between benign and tumour tissue. We also investigated the impact of structural variants on chromatin organization and identify novel enhancer hijacking events. These results …
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