The regulation of expression level in NeuroD/BETA2 by PKA

Post-translational regulation of bHLH transcription factors could be effected by phosphorylation, then NeuroD/BETA2 could be effected by phosphorylation too. NeuroD/BETA2 was phosphorylated at Ser336 by CaMKII, then formation of dendirte could be effected by phosphorylation of NeuroD/BETA2. NeuroD/BETA2 might be regulated by phosphorylation at post-translation level. For searching effect of phosphorylation of NeuroD/BETA2, We found kinase and phosphoryation site of NeuroD/BETA2. Treatment of 293T cells with forskolin overexpressed NeuroD/BETA2, expression of NeuroD/BETA2 was increased. And NeuroD/BETA2 could be phosphorylate at N-terminous region by PKA. We predicted that phosphorylation site of NeuroD/BETA2 was at Thr91, using databases: Netphos, PROSITE and ScanProsite.

Author dc:creator

• 신, 영국

Contributors dc:contributor

• 이, 영돈
• 대학원 의학과
• 200324271

• bHLH
• NeuroD/BETA2
• 인산화
• 인산화 효소
• PKA
• phosphorylation
• kinase
• protein stability

Language dc:language

ko

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000000183
000000000183

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/1482