Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 386 for “"PKA"”.
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Redox Regulation of Type Iα PKA in the Heart
… RIα subunits of cAMP-dependent protein kinase (PKA) form interprotein disulfides during oxidative stress which is associated with kinase activation. PKA classical activation involves cAMP binding to the regulatory subunits causing release of catalytic subunits which phosphorylate substrates. …
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PKA as an Upstream Kinase for LKB1/STRAD/MO25
… kinase for AMP-activated protein kinase (AMPK). PKA phosphorylates LKB1 at the Ser428 residue in humans and Ser431 residue in mice. We investigated PKA as an upstream kinase for LSMK. LKB1 that had been incubated with PKA prior to incubation with AMPK experienced up to a 51% increase in AMPK …
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The regulation of expression level in NeuroD/BETA2 by PKA
… could be phosphorylate at N-terminous region by PKA. We predicted that phosphorylation site of NeuroD/BETA2 was at Thr91, using databases: Netphos, PROSITE and ScanProsite.
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A Highly Charged Topic: Intrinsically Disordered Proteins and Protein pKa Values
… in IDPs are protonatable; depending on their pKa values, they will be (de)protonated at a specific solution pH. We considered how MD simulations alongside non-equilibrium free energy methods and theory could be used to compute coupled and uncoupled pKa values for more than 140 amino acid …
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Experimental and Prediction Approaches to Determine Dissociation Constants (pKa) of Amines
… work studied the dissociation constants (pKa) of eight amines [N-(2- Aminoethyl)-1,3-propanediamine, Bis[2-(N,N-dimethylamino)ethyl] ether, 2- Methylpentamethylene diamine, N,N-Dimethyldipropylenetriamine, 3,3’-Diamino-Nmethyldipropylamine, 2-[2-(Dimethylamino)ethoxy]ethanol, …
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Cγ- and Cα-Subunits Provide the Specificity for cAMP/PKA Function
… Cα and Cγ of the cAMP-dependent protein kinase (PKA) are two highly homologous (83% amino acid identity), yet functionally distinct isozymes <em>in vitro</em> for substrate and pseudosubstrate specificity, and in intact cells for cell phenotypes (Beebe, 1992).</p> <p>To determine the molecular …
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A Mis-Expression Screen Identifies a PKA -Anchoring Protein in Antenna Lobe Development
… of this gene. Akap200 is a Protein Kinase A (PKA) binding protein with multiple binding sites for other signaling molecules, including Protein Kinase C (PKC), Camodulin and F-actin. Further studies showed that ORN axons of the Akap200 mutants stall in the path to their targets. The loss of …
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Angiotensin-(1-9) prevents cardiomyocyte hypertrophy via miR-129-3p/PKIA/PKA signaling pathway
… in the activation of the protein kinase A (PKA) signaling pathway. Finally, we showed that the mere activation of PKA by angiotensin-(1-9) accounted for its effects on calcium handling and cardiomyocyte hypertrophy
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Towards the Design of an oligoTEA Endosomal Escape Agent: Investigations in Hydrophobicity and pKa
… design of an oligoTEA endosomal escape agent. pKa and hydrophobicity are two key parameters routinely used in assessing the viability of new drug delivery candidates. From partitioning data, bulk microscopic measurements of pKa and hydrophobicity were determined for a library consisting of …
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Regulation of MINK1 by APC, PKA and MARK3/4 and consequences for epithelial cell biology
… threonine-selective kinase. I demonstrated that PKA, MARK3 and MARK4 directly phosphorylate MINK1 on two phosphosites (S674 and S701) in the linker domain of MINK1, which in turn enables 14-3-3-binding to MINK1. ERM proteins play an essential role in mitotic spindle formation, orientation and …
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Pembelajaran Berasaskan Masalah (PBM) melalui penguasaan kemahiran teknikal dan kemahiran generik bagi mata pelajaran Pengajian Kejuruteraan Awam (PKA)
Kajian ini bertujuan berfokus terhadap mengenal pasti komponen penting pelaksanaan kerja kursus, komponen Pembelajaran Berasaskan Masalah, komponen kemahiran teknikal dan komponen kemahiran generik yang diperlukan dalam pelaksanaan kerja kursus mata pelajaran Pengajian Kejuruteraan Awam. Responden …
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Pembelajaran Berasaskan Masalah (PBM) melalui penguasaan kemahiran teknikal dan kemahiran generik bagi mata pelajaran Pengajian Kejuruteraan Awam (PKA)
Kajian ini bertujuan berfokus terhadap mengenal pasti komponen penting pelaksanaan kerja kursus, komponen Pembelajaran Berasaskan Masalah, komponen kemahiran teknikal dan komponen kemahiran generik yang diperlukan dalam pelaksanaan kerja kursus mata pelajaran Pengajian Kejuruteraan Awam. Responden …
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Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
… regulation of protein phosphatases when the cAMP–PKA signalling pathway is activated and study the isoform specificity of PP1. Most protein phosphatases of the PPP family do not exist as free catalytic subunits: instead, they interact with regulatory subunits, which specify, target and/or inhibit …
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Régulation de la prolifération et de la différenciation des cellules épithéliales intestinales par les cascades MEK/ERK et AMPc/PKA
… signalisation intracellulaires, MEK/ERK et AMPc/PKA, dans la prolifération et la différenciation des cellules épithéliales intestinales. Dans un premier temps, nous avons montré que la cascade MEK/ERK est nécessaire mais non suffisante à la prolifération des cellules épithéliales intestinales. …
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Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
… downstream pathways, Ca2+-PKC and cAMP-PKA respectively. The histamine- induced elevation of ICAM-1 was mediated through HI receptors and PKC. Role of PKC in ST ATI phosphorylation has been established however role of PKA has not been studied yet. In this study we delineated the role of …
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Influence of the members of Ras/PKA signal transduction pathway on the yeast Saccharomyces cerevisiae cell death induced by natural acidification of the medium /
… One of the universal signaling systems is Ras/PKA signal transduction pathway. This system helps cells recognize the nutrient sources present in the growth medium.Environmental pH is one of the main factors influencing the growth, physiology and differentiation of yeast. In Saccharomyces …
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