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Showing 1 to 20 of 84 for “"bHLH"”.
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Regulation der Neurogenese durch bHLH-O-Proteine in Xenopus laevis
bHLH-Aktivatoren und bHLH-Repressoren sind an zahlreichen Entwicklungsprozessen, einschließlich der Ausbildung des Nervensystems, in Vertebraten und Invertebraten beteiligt. Bei der Bestimmung neuraler Zellschicksale und der Regulation der Neurogenese spielen insbesondere bHLH-O-Proteine eine …
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Early land plant origins of the MYB-bHLH-WDR complex
… composed of a MYB transcription factor, a bHLH transcription factor and a WD repeat scaffold (MYB-bHLH-WDR or MBW complexes) regulate patterns of flavonoid pigments, trichomes and root hairs in this cell layer. We reasoned that investigating the origins and diversification of the MBW …
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Analyse und Visualisierung eines R2R3-MYB / bHLH Transkriptionsfaktorkomplexes aus Arabidopsis thaliana
… were analysed in detail, MYB75 as well as BHLH2/BHLH42 and TTG1. These are regulators of the dihydroflavonol-reductase (DFR), the key enzyme of the anthocyanin biosynthesis. To understand the regulatory mechanism, binding of transcription factors among each other and to the target-DNA was …
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The bHLH/PAS Transcription Factor SIM1 Is a Novel Obesity Gene
Obesity is epidemic in the United States and other developed countries. Obesity is a major risk factor for type II diabetes, hypertension, hyperlipidemia and osteoarthritis. I report a unique girl with early-onset obesity (47.5 kg, +9.3 s.d. above mean at age 67 months) and a de novo balanced …
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Intrinsic Specificity of Binding and Regulatory Function of Class II bHLH Transcription Factors
… and MYOD are class II basic Helix-Loop-Helix (bHLH) transcription factors which play crucial roles in lineage specification in the developing embryo. In vivo, these factors bind to distinct genomic sites, and regulate distinct transcriptional programs. The mechanisms by which they select their …
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Analysis of the Role of bHLH/PAS Proteins in Aryl Hydrocarbon Receptor Signaling
… (AHR) is a basic helix-loop-helix PER/ARNT/SIM (bHLH-PAS) transcription factor that binds ligands typified by 2,3,7,8-tetracholordibenzo-p-dioxin, translocates to the nucleus, dimerizes with the aryl hydrocarbon nuclear translocator (ARNT) and associates with specific cis xenobiotic response …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… in these events are basic helix-loop-helix (bHLH) genes: Neurogl, Atohl and Neurodl. We investigated whether co-expression of Neurogl and Atohl in common neurosensory precursors could explain the loss of hair cells in Neurogl null mice. Analysis of terminal mitosis, using BrdU, supports …
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Control of Cardiac and Limb Development by the bHLH Transcription Factors DHAND and eHAND
Members of the basic helix-loop-helix (bHLH) transcription factor family regulate the specification and differentiation of multiple cell lineages during embryonic development. The bHLH proteins dHAND and eHAND are expressed in complimentary and overlapping patterns during embryogenesis, and gene …
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Investigating mechanisms and biological functions of the bHLH/PAS transcription factors SIM1 and ARNT2
The basic Helix-Loop-Helix/PER-ARNT-SIM (bHLH/PAS) family of transcription factors are involved in gene regulation during both embryonic development and throughout adulthood to maintain cellular homeostasis. Members of this family must heterodimerise to activate or repress target gene expression. …
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Untersuchungen zur Funktion des basischen Helix-Loop-Helix (bHLH)-Transkriptionsfaktors ME2 bei Lern- und Gedächtnisprozessen in der Maus
… zu der Familie der basischen Helix-Loop-Helix (bHLH) Transkriptionsfaktoren und aktiviert die Transkription von Zielgenen mittels Bindung an E-Boxen. Die ME2 mRNA-Expression bleibt in adulten zentralen Nervensystem (ZNS) erhalten. Da heterozygote ME2-knockout-Mäuse keinen offensichtlichen …
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Analysis of phytochrome signaling pathways in Zea mays
… interacting factors), a sub-family of bHLH proteins. The recent whole genome duplication in maize may have led to divergence in the structure and function of phytochrome mediated signaling pathways. Here, I found that ZmphyB1, one of the phyB homeologs, interacts with a bHLH protein …
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Identification of an aqueous glue protein, SCP-2, and the development of a polyclonal antiserum against the bHLH transcription factor SGSF in Latrodectus Hesperus
… lab has developed the first antibody against the bHLH factor SGSF. SGSF has been implicated as a potential transcriptional regulator of silk gene transcription in spiders. Development of the anti-SGSF antibody was accomplished via the overexpression and purification of a fusion protein in …
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Mapping of the repression domain and the subcellular localization of the ABF-1 protein
… heart. A recently discovered B-cell restricted bHLH transcription factor activated Bcell factor 1 (ABF -1) is suspected to play a role in the regulation of B cell differentiation. ABF -1 was initially characterized as being a transcriptional repressor because it was able to prevent the …
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Part I characterization of MyoR in C2C12 mouse fibroblasts. Part II isolation and characterization of a novel class II bHLH transcription factor from the black widow spider, latrodectus hesperus
<p>PART I</p> <p>The basic helix-loop-helix (bHLH) family of transcription factors are involved in a variety of developmental processes. MyoR is the mouse homologue of the human transcription factor ABF-1 . MyoR is classified as a class II basic-helix-loop-helix transcription factor. In order to …
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The characterization of the ABF-1 promoter
<p>The basic helix-loop-helix (bHLH) family oftranscription factors consists of proteins involved in cellular proliferation and differentiation. The HLH structure plays a key role in protein-protein dimerization and with the DNA target sites, referred to as E boxes containing the consensus DNA …
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Funktionen und Interaktionen von Homöodomänenproteinen während der Entwicklung des Rückenmarks
… Neurone. Sie erhalten hierbei die Expression des bHLH (basic Helix-Loop-Helix) Proteins Mash1, ein essentieller Faktor für ein erregendes dI3 und dI5 Zellschicksal, aufrecht, indem sie den bHLH Transkriptionsfaktor Ngn1 hemmen. Die Expression dieses Proteins grenzt im Wildtyp sowohl dorsal als …
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Isolation of novel ABF-1 splice forms
… member belonging to the basic helix-loop-helix (bHLH) family of transcription factors whose expression pattern is restricted to B cells. ABF-1 forms heterodirner complexes with E2A to modulate gene transcription. Here we report the isolation often novel ABF-1 splice products from a human B-cell …
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Molecular Mechanisms Underlying Functions of Juvenile Hormone Receptor
… gene regulation by JH via Met. Met is a bHLH-PAS (basic-helix-loop-helix Per-ARNT-Sim) family protein. Many proteins in this family function as heterodimers formed with other proteins of this family. In a yeast two-hybrid screening, we discovered that another bHLH-PAS family protein, …
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