Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 325 for “"MMP"”.
-
Imagerie moléculaire de la MMP-2
Les métalloprotéinases de matrice (MMPs) sont des enzymes impliquées dans la restructuration tissulaire et la migration cellulaire. La MMP-2, en particulier, a été reconnue comme biomarqueur de la progression ou du pronostic de plusieurs pathologies, comme l'arthrite, l'athérosclérose, l'infarctus …
-
MECHANISM OF TRANSCRIPTIONAL REPRESSION OF MMP-9 BY INTERFERON-β
<p>Matrix metalloproteinase-9 (MMP-9) is a 92 kDa zinc-dependant endopeptidase that degrades components of the extracellular matrix. Enhanced expression of MMP-9 has been implicated in many pathological conditions including cancer metastasis, multiple sclerosis, and atherosclerosis. Although it has …
-
Astaxanthin Decreases Invasion and MMP Activity in Triple Negative Breast Cancer Cells
… treated with Astaxanthin demonstrate decreased MMP-2, -9, and -13 activities. Western blot analysis of conditioned media and lysates suggests that decreased MMP activity results from decreased protein expression. Using a broad-spectrum MMP inhibitor we observed a decrease in invasion of 4T1 …
-
Glomerulosclerosis in the Col1a2-deficient mouse model : homotrimer pathogenesis and MMP expression
… expression of type I collagen and MMPs -2, -3, and -9 in wildtype, heterozygous and Col1a2-deficient glomeruli to determine whether the pathogenic collagen is homotrimeric in nature, and whether alterations in MMP expression play a role in disease progression. Analysis of whole …
-
The political field and public relations : Competing discourses in New Zealand’s first MMP election
This thesis uses Norman Fairclough’s model of critical discourse analysis to analyse the campaign discourse of each of the five main political parties that contested the New Zealand general election in 1996. The parties were: The National Party, the New Zealand Labour Party, New Zealand First, Act …
-
Investigation of the functions of Matrix Metalloproteinase-8 (MMP-8) in Mammary Carcinoma Cells
… understanding. The matrix metalloproteinases (MMPs) are a family of proteases thought to promote metastasis due to their matrix degradation capabilities. MMP-8 however has been discovered to be anti-tumourigenic in many cancers, and anti-metastatic in breast cancer. This occurs through unknown …
-
MMP-7 nanosensors for urine-based detection of chemotherapy-induced senescence and pulmonary fibrosis
… cancer patients, matrix metalloproteinase-7 (MMP-7) was identified as unique metalloprotease secreted by chemotherapy-induced senescent lung cancer cells (Chapter 4). This protease was then utilised to develop an ALBANC nanosensor (Figure 1), comprising human serum albumin covalently linked to …
-
The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes
… enzymes called matrix metalloproteinases (MMPs). Fibronectin fragment (FN-f) stimulation of the &alpha5&beta1 integrin increases intracellular levels of ROS in chondrocytes, while antioxidants block FN-f stimulated MMP-13 expression, demonstrating ROS are critical regulators of this …
-
Nfat1 Contributes to Melanoma Tumor Growth and Metastasis By Regulating Il-8 and Mmp-3
… two downstream targets of NFAT1, i.e; IL-8 and MMP-3 to be downregulated following silencing NFAT1. While silencing of NFAT1 reduced IL-8 and MMP-3 in highly metastatic cell lines, A375SM and WM902B, overexpression of NFAT1 in the low metastatic cell line, SB2 induced the expression of both IL-8 …
-
Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum
<p>Matrix metalloproteinases (MMPs) have been postulated to be important for angiogenesis and for tissue remodeling events associated with corpus luteum (CL) development. The MMPs are mainly regulated at three levels, transcription, activation, and inhibition by endogenous tissue inhibitors of …
-
Lipoteichoic acid from Staphylococcus aureus induced expression of MMP-9 in human middle ear epithelial cells
Change in matrix metalloproteinases (MMPs) and regulation of their tissue inhibitors of metalloproteinases (TIMPs) could play certain role in the pathogenesis of otitis media. This study was designed to evaluate the modulation of MMPs and TIMPs in middle ear epithelium by lipoteichoic acid (LTA) …
-
Comparison of Plasma MMP and TIMP Concentration Related to Albumine Excretion Rate in Type 2 Diabetes
… 단백뇨 군 20명으로 대상으로 병력 청취, 신체 계측을 시행하고 ELISA법으로 혈청 MMP-2, MMP-9, TIMP-1 농도를 측정하였다. 결과: 혈청 MMP-2, MMP-9, TIMP-1 농도를 측정한 결과 MMP-2와 MMP-9의 농도는 각 군에서 차이를 보이지 않았으며 TIMP-1은 단백뇨가 많이 배설되는 군 일수록 통계학적으로 유의하게 혈청 농도가 증가되는 결과를 나타내었다. 결론: 당뇨병성 신증의 특징인 세포 외 기질의 분해 감소 및 침착 증가가 일어나는 과정에서 TIMP-1이 영향을 미칠 것으로 보인다. "
-
The regulation of matrix metalloproteinase (MMP) secretion in human vascular cells exposed to extracellular and wound matrices
Proteolytic degradation is a central feature of the cellular remodelling in wounds during healing. The regulation of matrix metalloproteinases (a key superfamily of proteases involved in the above process) by wound healing components is an area of ongoing investigation. However, a systematic study …
-
Characterization and Functional Analysis of a Newly Identified Human MT5-MMP Transcript Variant Isolated from Multipotent NT2 Cells
Membrane-type 5 matrix metalloproteinase (MT5-MMP) is unique among MMP family members as it is predominately expressed in the CNS. Its expression is ubiquitous during brain development and restricted to regions of neurogenesis and neuroplasticity in the adult. MT5-MMP is a mediator of pericellular …
-
Die Expression und Lokalisation von Matrix Metalloproteinasen (MMP) und ihrer spezifischen endogenen Inhibitoren (TIMP) in menschlichen primären Gehirntumoren
… und Aktivierung von Matrix Metalloproteinasen (MMP) und ihrer spezifischen Inhibitoren (TIMP) in primären menschlichen Gehirntumoren zu beschreiben, und die Proteine im Gewebe zu lokalisieren. Ausganshypothese war, dass es bei der malignen Progression von Gliomen zu einer Zunahme der …
-
MT1-MMP enhances cell survival and proliferation via roles unrelated to metabolic transcript levels in MCF7 breast cancer cells
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a multifunctional protease implicated in cancer aggressiveness for its ability to promote proliferation, migration, and invasion, particularly at low expression levels. Due to its multidomain structure and cell signalling abilities, MT1-MMP may …
-
Identification and characterization of a matrix metalloproteinase (Pta1-MMP) expressed during Loblolly pine (Pinus taeda) seed development and germination
… the extracellular matrix metalloproteinases (MMPs), have also been described in a few plants. Here, we report the identification of Loblolly pine (Pinus taeda) Pta1-MMP and its characterization during seed development and germination. The Pta1-MMP protein has the structural characteristics of …
-
Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
… severe side effects. Matrix metalloproteinases (MMPs) represent the most prominent family of endopeptidases that are necessary for normal growth and development but are also involved in the disruption of the blood-brain barrier (BBB), neuronal cell death, neuroinflammation and/or …
Page 1 of 17