The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes

Elevated levels of reactive oxygen species (ROS) have been observed in the cartilage of osteoarthritis (OA) patients and may contribute to the degradation of the articular cartilage extracellular matrix (ECM). ROS have been shown to serve as secondary messengers in integrin and cytokine signaling pathways which stimulate chondrocyte production of ECM-degrading enzymes called matrix metalloproteinases (MMPs). Fibronectin fragment (FN-f) stimulation of the &alpha5&beta1 integrin increases intracellular levels of ROS in chondrocytes, while antioxidants block FN-f stimulated MMP-13 expression, demonstrating ROS are critical regulators of this pathway. However, the means by which ROS regulate this pathway are unknown. Therefore, the objective of this work was to investigate the source of ROS and the mechanism by which ROS mediate the FN-f stimulation of MMP production.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2011

Author dc:creator

• Erickson, Elizabeth Alice

• MAP kinases

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/36425

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/36425