The regulation of matrix metalloproteinase (MMP) secretion in human vascular cells exposed to extracellular and wound matrices

Proteolytic degradation is a central feature of the cellular remodelling in wounds during healing. The regulation of matrix metalloproteinases (a key superfamily of proteases involved in the above process) by wound healing components is an area of ongoing investigation. However, a systematic study of the exposure of the human derived vascular cells - endothelial cells, fibroblasts, smooth muscle cells and macrophages - to well defined ECM (collagen type I, III and IV and laminin) and wound healing matrix proteins (fibrin and plasma fibronectin) has not yet beeen carried out.

Grantor dc:publisher.institution

Department of Medicine

Year dc:date.issued

2002

Author dc:creator

• Bracher, Mona

Advisors dc:contributor.advisor

• Davies, Neil
• Zilla, Peter

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3368

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3368