{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3368"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3368","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The regulation of matrix metalloproteinase (MMP) secretion in human vascular cells exposed to extracellular and wound matrices","abstract":"Proteolytic degradation is a central feature of the cellular remodelling in wounds during healing. The regulation of matrix metalloproteinases (a key superfamily of proteases involved in the above process) by wound healing components is an area of ongoing investigation. However, a systematic study of the exposure of the human derived vascular cells - endothelial cells, fibroblasts, smooth muscle cells and macrophages - to well defined ECM (collagen type I, III and IV and laminin) and wound healing matrix proteins (fibrin and plasma fibronectin) has not yet beeen carried out.","abstract_html":"Proteolytic degradation is a central feature of the cellular remodelling in wounds during healing. The regulation of matrix metalloproteinases (a key superfamily of proteases involved in the above process) by wound healing components is an area of ongoing investigation. However, a systematic study of the exposure of the human derived vascular cells - endothelial cells, fibroblasts, smooth muscle cells and macrophages - to well defined ECM (collagen type I, III and IV and laminin) and wound healing matrix proteins (fibrin and plasma fibronectin) has not yet beeen carried out.","abstract_has_math":false,"creators":["Bracher, Mona"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Davies, Neil","Zilla, Peter"],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002","date_published":"2002","updated_at":"2026-07-22T22:22:54Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3368","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Davies, Neil","Zilla, Peter"]},{"key":"dc:creator","label":"Author","values":["Bracher, Mona"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-29T09:02:51Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-29T09:02:51Z"]},{"key":"dc:date.issued","label":"Date","values":["2002"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["MSc"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3368"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["Proteolytic degradation is a central feature of the cellular remodelling in wounds during healing. The regulation of matrix metalloproteinases (a key superfamily of proteases involved in the above process) by wound healing components is an area of ongoing investigation. However, a systematic study of the exposure of the human derived vascular cells - endothelial cells, fibroblasts, smooth muscle cells and macrophages - to well defined ECM (collagen type I, III and IV and laminin) and wound healing matrix proteins (fibrin and plasma fibronectin) has not yet beeen carried out."]},{"key":"dc:title","label":"Title","values":["The regulation of matrix metalloproteinase (MMP) secretion in human vascular cells exposed to extracellular and wound matrices"]}]}],"canonical_facts":{"dc:contributor.advisor":["Davies, Neil","Zilla, Peter"],"dc:creator":["Bracher, Mona"],"dc:date.accessioned":["2014-07-29T09:02:51Z"],"dc:date.available":["2014-07-29T09:02:51Z"],"dc:date.issued":["2002"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["Proteolytic degradation is a central feature of the cellular remodelling in wounds during healing. The regulation of matrix metalloproteinases (a key superfamily of proteases involved in the above process) by wound healing components is an area of ongoing investigation. However, a systematic study of the exposure of the human derived vascular cells - endothelial cells, fibroblasts, smooth muscle cells and macrophages - to well defined ECM (collagen type I, III and IV and laminin) and wound healing matrix proteins (fibrin and plasma fibronectin) has not yet beeen carried out."],"dc:identifier.uri":["http://hdl.handle.net/11427/3368"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The regulation of matrix metalloproteinase (MMP) secretion in human vascular cells exposed to extracellular and wound matrices"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["MSc"],"dc:type.qualificationname":["Thesis"]},"updated_at":"2026-07-22T22:22:54Z"}