Brain Injury and Inflammation and Placental Inflammation in Response to Repetitive Umbilical Cord Occlusions in the Near Term Ovine Fetus

We hypothesized that repetitive umbilical cord occlusions (UCOs) leading to severe acidemia will stimulate a placental and fetal inflammatory response associated with brain injury, which will be exacerbated by chronic hypoxemia and low-grade infection. Chronically instrumented fetal sheep served as controls or underwent repetitive UCOs for up to 4 hours or until fetal arterial pH was2saturation pre-UCOs of >55% and

Name thesis:degree_name

M Sc

Discipline thesis:degree_discipline

Physiology

Grantor dc:publisher

The University of Western Ontario

Year dc:date.issued

2015

Author dc:creator

• Xu, Alex

Advisor dc:contributor.advisor

• Richardson, Bryan S.

• Fetal hypoxia
• placental inflammation
• LPS
• microglia
• brain apoptosis
• interleukin 6

Language dc:language.iso

en_ca

Handle dc:identifier.uri

https://hdl.handle.net/20.500.14721/33507

OAI identifier oai:identifier

oai:uwo.scholaris.ca:20.500.14721/33507